| Identification |
|---|
| HMDB Protein ID
| CDBP00665 |
| Secondary Accession Numbers
| Not Available |
| Name
| Flavin reductase (NADPH) |
| Description
| Not Available |
| Synonyms
|
- BVR-B
- Biliverdin reductase B
- Biliverdin-IX beta-reductase
- FLR
- FR
- GHBP
- Green heme-binding protein
- NADPH-dependent diaphorase
- NADPH-flavin reductase
|
| Gene Name
| BLVRB |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in catalytic activity |
| Specific Function
| Broad specificity oxidoreductase that catalyzes the NADPH-dependent reduction of a variety of flavins, such as riboflavin, FAD or FMN, biliverdins, methemoglobin and PQQ (pyrroloquinoline quinone). Contributes to heme catabolism and metabolizes linear tetrapyrroles. Can also reduce the complexed Fe(3+) iron to Fe(2+) in the presence of FMN and NADPH. In the liver, converts biliverdin to bilirubin.
|
| GO Classification
|
| Biological Process |
| small molecule metabolic process |
| heme catabolic process |
| Cellular Component |
| cytosol |
| plasma membrane |
| nucleus |
| Function |
| binding |
| catalytic activity |
| Molecular Function |
| biliverdin reductase activity |
| riboflavin reductase (NADPH) activity |
| nucleotide binding |
| Process |
| metabolic process |
|
| Cellular Location
|
- Cytoplasm
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Porphyrin and chlorophyll metabolism | Not Available |  |
|
| Gene Properties |
|---|
| Chromosome Location
| 19 |
| Locus
| 19q13.1-q13.2 |
| SNPs
| BLVRB |
| Gene Sequence
|
>621 bp
ATGGCCGTCAAGAAGATCGCGATCTTCGGCGCCACTGGCCAGACCGGGCTCACCACCCTG
GCGCAGGCGGTGCAAGCAGGTTACGAAGTGACAGTGCTGGTGCGGGACTCCTCCAGGCTG
CCATCAGAGGGGCCCCGGCCGGCCCACGTGGTAGTGGGAGATGTTCTGCAGGCAGCCGAT
GTGGACAAGACCGTGGCTGGGCAGGACGCTGTCATCGTGCTGCTGGGCACCCGCAATGAC
CTCAGTCCCACGACAGTGATGTCCGAGGGCGCCCGGAACATTGTGGCAGCCATGAAGGCT
CATGGTGTGGACAAGGTCGTGGCCTGCACCTCGGCTTTCCTGCTCTGGGACCCTACCAAG
GTGCCCCCACGACTGCAGGCTGTGACTGATGACCACATCCGGATGCACAAGGTGCTGCGG
GAATCAGGCCTGAAGTACGTGGCTGTGATGCCGCCACACATAGGAGACCAGCCACTAACT
GGGGCGTACACAGTGACCCTGGATGGACGAGGGCCCTCAAGGGTCATCTCCAAACATGAC
CTGGGCCATTTCATGCTGCGCTGCCTCACCACCGATGAGTACGACGGACACAGCACCTAC
CCCTCCCACCAGTACCAGTAG
|
| Protein Properties |
|---|
| Number of Residues
| 206 |
| Molecular Weight
| 22119.215 |
| Theoretical pI
| 7.643 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Flavin reductase
MAVKKIAIFGATGQTGLTTLAQAVQAGYEVTVLVRDSSRLPSEGPRPAHVVVGDVLQAAD
VDKTVAGQDAVIVLLGTRNDLSPTTVMSEGARNIVAAMKAHGVDKVVACTSAFLLWDPTK
VPPRLQAVTDDHIRMHKVLRESGLKYVAVMPPHIGDQPLTGAYTVTLDGRGPSRVISKHD
LGHFMLRCLTTDEYDGHSTYPSHQYQ
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| P30043 |
| UniProtKB/Swiss-Prot Entry Name
| BLVRB_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| D26308 |
| GeneCard ID
| BLVRB |
| GenAtlas ID
| BLVRB |
| HGNC ID
| HGNC:1063 |
| References |
|---|
| General References
| Not Available |