| Identification |
|---|
| HMDB Protein ID
| CDBP00664 |
| Secondary Accession Numbers
| Not Available |
| Name
| Biliverdin reductase A |
| Description
| Not Available |
| Synonyms
|
- BVR A
- Biliverdin-IX alpha-reductase
|
| Gene Name
| BLVRA |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in biliverdin reductase activity |
| Specific Function
| Reduces the gamma-methene bridge of the open tetrapyrrole, biliverdin IX alpha, to bilirubin with the concomitant oxidation of a NADH or NADPH cofactor.
|
| GO Classification
|
| Biological Process |
| small molecule metabolic process |
| heme catabolic process |
| Cellular Component |
| cytosol |
| Component |
| cell part |
| intracellular part |
| cytoplasm |
| Function |
| transition metal ion binding |
| zinc ion binding |
| oxidoreductase activity, acting on the ch-ch group of donors, nad or nadp as acceptor |
| biliverdin reductase activity |
| oxidoreductase activity |
| oxidoreductase activity, acting on the ch-ch group of donors |
| ion binding |
| cation binding |
| metal ion binding |
| binding |
| catalytic activity |
| Molecular Function |
| metal ion binding |
| biliverdin reductase activity |
| zinc ion binding |
| nucleotide binding |
| Process |
| metabolic process |
| nitrogen compound metabolic process |
| tetrapyrrole metabolic process |
| porphyrin metabolic process |
| porphyrin catabolic process |
| heme catabolic process |
| oxidation reduction |
|
| Cellular Location
|
- Cytoplasm
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Porphyrin Metabolism |    |  | | protoheme degradation | Not Available | Not Available | | Porphyrin and chlorophyll metabolism | Not Available | | | Acute Intermittent Porphyria |    | Not Available | | Porphyria Variegata (PV) |    | Not Available |
|
| Gene Properties |
|---|
| Chromosome Location
| 7 |
| Locus
| 7p13 |
| SNPs
| BLVRA |
| Gene Sequence
|
>891 bp
ATGAATGCAGAGCCCGAGAGGAAGTTTGGCGTGGTGGTGGTTGGTGTTGGCCGAGCCGGC
TCCGTGCGGATGAGGGACTTGCGGAATCCACACCCTTCCTCAGCGTTCCTGAACCTGATT
GGCTTCGTGTCGAGAAGGGAGCTCGGGAGCATTGATGGAGTCCAGCAGATTTCTTTGGAG
GATGCTCTTTCCAGCCAAGAGGTGGAGGTCGCCTATATCTGCAGTGAGAGCTCCAGCCAT
GAGGACTACATCAGGCAGTTCCTTAATGCTGGCAAGCACGTCCTTGTGGAATACCCCATG
ACACTGTCATTGGCGGCCGCTCAGGAACTGTGGGAGCTGGCTGAGCAGAAAGGAAAAGTC
TTGCACGAGGAGCATGTTGAACTCTTGATGGAGGAATTCGCTTTCCTGAAAAAAGAAGTG
GTGGGGAAAGACCTGCTGAAAGGGTCGCTCCTCTTCACAGCTGGCCCGTTGGAAGAAGAG
CGGTTTGGCTTCCCTGCATTCAGCGGCATCTCTCGCCTGACCTGGCTGGTCTCCCTCTTT
GGGGAGCTTTCTCTTGTGTCTGCCACTTTGGAAGAGCGAAAGGAAGATCAGTATATGAAA
ATGACAGTGTGTCTGGAGACAGAGAAGAAAAGTCCACTGTCATGGATTGAAGAAAAAGGA
CCTGGTCTAAAACGAAACAGATATTTAAGCTTCCATTTCAAGTCTGGGTCCTTGGAGAAT
GTGCCAAATGTAGGAGTGAATAAGAACATATTTCTGAAAGATCAAAATATATTTGTCCAG
AAACTCTTGGGCCAGTTCTCTGAGAAGGAACTGGCTGCTGAAAAGAAACGCATCCTGCAC
TGCCTGGGGCTTGCAGAAGAAATCCAGAAATATTGCTGTTCAAGGAAGTAA
|
| Protein Properties |
|---|
| Number of Residues
| 296 |
| Molecular Weight
| 33428.225 |
| Theoretical pI
| 6.449 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Biliverdin reductase A
MNAEPERKFGVVVVGVGRAGSVRMRDLRNPHPSSAFLNLIGFVSRRELGSIDGVQQISLE
DALSSQEVEVAYICSESSSHEDYIRQFLNAGKHVLVEYPMTLSLAAAQELWELAEQKGKV
LHEEHVELLMEEFAFLKKEVVGKDLLKGSLLFTAGPLEEERFGFPAFSGISRLTWLVSLF
GELSLVSATLEERKEDQYMKMTVCLETEKKSPLSWIEEKGPGLKRNRYLSFHFKSGSLEN
VPNVGVNKNIFLKDQNIFVQKLLGQFSEKELAAEKKRILHCLGLAEEIQKYCCSRK
|
| External Links |
|---|
| GenBank ID Protein
| 33589854 |
| UniProtKB/Swiss-Prot ID
| P53004 |
| UniProtKB/Swiss-Prot Entry Name
| BIEA_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| NM_000712.3 |
| GeneCard ID
| BLVRA |
| GenAtlas ID
| BLVRA |
| HGNC ID
| HGNC:1062 |
| References |
|---|
| General References
| Not Available |