Cannabis Compound Database: Showing Protein 3-oxo-5-alpha-steroid 4-dehydrogenase 1 (CDBP00663)

Identification Biological properties Gene properties Protein properties External links References XML Show 2 compounds

Identification

HMDB Protein ID

CDBP00663

Secondary Accession Numbers

Not Available

Name

3-oxo-5-alpha-steroid 4-dehydrogenase 1

Description

Not Available

Synonyms

S5AR 1
SR type 1
Steroid 5-alpha-reductase 1

Gene Name

SRD5A1

Protein Type

Enzyme

Biological Properties

General Function

Involved in 3-oxo-5-alpha-steroid 4-dehydrogenase activity

Specific Function

Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology.

GO Classification

Biological Process
response to growth hormone stimulus
cell differentiation
cellular response to testosterone stimulus
cellular response to starvation
cerebral cortex development
male gonad development
liver development
bone development
response to drug
male genitalia development
cellular response to epinephrine stimulus
serotonin metabolic process
cellular response to estradiol stimulus
cellular response to growth factor stimulus
circadian sleep/wake cycle, REM sleep
pituitary gland development
diterpenoid metabolic process
cellular response to dexamethasone stimulus
response to muscle activity
small molecule metabolic process
androgen biosynthetic process
sex determination
response to follicle-stimulating hormone stimulus
urogenital system development
hippocampus development
cellular response to insulin stimulus
response to fungicide
spinal cord development
thalamus development
hypothalamus development
female genitalia development
cellular response to cAMP
progesterone metabolic process
Cellular Component
endoplasmic reticulum membrane
perinuclear region of cytoplasm
cell body fiber
myelin sheath
neuronal cell body
integral to membrane
Component
membrane
cell part
intracellular part
cytoplasm
membrane part
intrinsic to membrane
integral to membrane
Function
oxidoreductase activity, acting on the ch-ch group of donors
catalytic activity
steroid dehydrogenase activity, acting on the ch-ch group of donors
3-oxo-5-alpha-steroid 4-dehydrogenase activity
oxidoreductase activity
steroid dehydrogenase activity
Molecular Function
cholestenone 5-alpha-reductase activity
NADPH binding
electron carrier activity
amide binding
3-oxo-5-alpha-steroid 4-dehydrogenase activity
Process
metabolic process
primary metabolic process
oxidation reduction
lipid metabolic process
steroid metabolic process

Cellular Location

Multi-pass membrane protein (Potential)
Endoplasmic reticulum membrane
Multi-pass membrane protein
Microsome membrane

Pathways

Name	SMPDB/Pathwhiz	KEGG
Steroid hormone biosynthesis	Not Available
Androgen and Estrogen Metabolism
17-Beta Hydroxysteroid Dehydrogenase III Deficiency		Not Available
Aromatase deficiency		Not Available
Androstenedione Metabolism		Not Available

Gene Properties

Chromosome Location

Locus

5p15

SNPs

SRD5A1

Gene Sequence

>780 bp
ATGGCAACGGCGACGGGGGTGGCGGAGGAGCGCCTGCTGGCCGCGCTCGCCTACCTGCAG
TGCGCCGTGGGCTGCGCGGTCTTCGCGCGGAATCGTCAGACGAACTCAGTGTACGGCCGC
CACGCGCTGCCCAGCCACAGGCTCCGAGTGCCGGCGCGGGCCGCCTGGGTGGTGCAGGAG
CTGCCCTCGCTGGCCCTGCCGCTCTACCAGTACGCCAGCGAGTCCGCCCCGCGTCTCCGC
AGCGCGCCCAACTGCATCCTCCTGGCCATGTTCCTCGTCCACTACGGGCATCGGTGCTTA
ATTTACCCGTTTCTGATGCGAGGAGGAAAGCCTATGCCACTGTTGGCATGTACAATGGCG
ATTATGTTCTGTACCTGTAACGGCTATTTGCAAAGCAGATACTTGAGCCATTGTGCAGTG
TATGCTGATGACTGGGTAACAGATCCCCGTTTTCTAATAGGTTTTGGCTTGTGGTTAACA
GGCATGTTGATAAACATCCATTCAGATCATATCCTAAGGAATCTCAGAAAACCAGGAGAT
ACTGGATACAAAATACCAAGGGGAGGCTTATTTGAATACGTAACTGCAGCCAACTATTTT
GGAGAAATCATGGAGTGGTGTGGCTATGCCCTGGCCAGCTGGTCTGTCCAAGGCGCGGCT
TTTGCTTTCTTCACGTTTTGTTTTTTATCTGGTAGAGCAAAAGAGCATCATGAGTGGTAC
CTCCGGAAATTTGAAGAGTATCCAAAGTTCAGAAAAATTATAATTCCATTTTTGTTTTAA

Protein Properties

Number of Residues

259

Molecular Weight

29458.18

Theoretical pI

8.942

Pfam Domain Function

Steroid_dh (PF02544 )

Signals

Not Available

Transmembrane Regions

Not Available

Protein Sequence

>3-oxo-5-alpha-steroid 4-dehydrogenase 1
MATATGVAEERLLAALAYLQCAVGCAVFARNRQTNSVYGRHALPSHRLRVPARAAWVVQE
LPSLALPLYQYASESAPRLRSAPNCILLAMFLVHYGHRCLIYPFLMRGGKPMPLLACTMA
IMFCTCNGYLQSRYLSHCAVYADDWVTDPRFLIGFGLWLTGMLINIHSDHILRNLRKPGD
TGYKIPRGGLFEYVTAANYFGEIMEWCGYALASWSVQGAAFAFFTFCFLSGRAKEHHEWY
LRKFEEYPKFRKIIIPFLF

External Links

GenBank ID Protein

Not Available

UniProtKB/Swiss-Prot ID

P18405

UniProtKB/Swiss-Prot Entry Name

S5A1_HUMAN

PDB IDs

Not Available

GenBank Gene ID

M32313

GeneCard ID