| Identification |
|---|
| HMDB Protein ID
| CDBP00652 |
| Secondary Accession Numbers
| Not Available |
| Name
| Aminomethyltransferase, mitochondrial |
| Description
| Not Available |
| Synonyms
|
- GCVT
- Glycine cleavage system T protein
|
| Gene Name
| AMT |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in aminomethyltransferase activity |
| Specific Function
| The glycine cleavage system catalyzes the degradation of glycine.
|
| GO Classification
|
| Biological Process |
| glycine catabolic process |
| Cellular Component |
| mitochondrion |
| Component |
| cell part |
| intracellular part |
| cytoplasm |
| Function |
| catalytic activity |
| transferase activity |
| aminomethyltransferase activity |
| transferase activity, transferring one-carbon groups |
| methyltransferase activity |
| Molecular Function |
| transaminase activity |
| aminomethyltransferase activity |
| Process |
| cellular amino acid metabolic process |
| metabolic process |
| cellular metabolic process |
| serine family amino acid metabolic process |
| glycine metabolic process |
| glycine catabolic process |
| cellular amino acid and derivative metabolic process |
|
| Cellular Location
|
- Mitochondrion
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Glycine, serine and threonine metabolism | Not Available |  | | One carbon pool by folate | Not Available |  | | Glycine and Serine Metabolism |    | | | Dimethylglycine Dehydrogenase Deficiency |    | Not Available | | Dihydropyrimidine Dehydrogenase Deficiency (DHPD) |    | Not Available |
|
| Gene Properties |
|---|
| Chromosome Location
| 3 |
| Locus
| 3p21.2-p21.1 |
| SNPs
| AMT |
| Gene Sequence
|
>1212 bp
ATGCAGAGGGCTGTAAGTGTGGTGGCCCGTCTGGGCTTTCGCCTGCAGGCATTCCCCCCG
GCCTTGTGTCGTCCACTTAGTTGCGCACAGGAGGTGCTCCGCAGGACACCGCTCTATGAC
TTCCACCTGGCCCACGGCGGGAAAATGGTGGCGTTTGCGGGTTGGAGTCTGCCAGTGCAG
TACCGGGACAGTCACACTGACTCGCACCTGCACACACGCCAGCACTGCTCGCTCTTTGAC
GTGTCTCATATGCTGCAGACCAAGATACTTGGTAGTGACCGGGTGAAGCTGATGGAGAGT
CTAGTGGTTGGAGACATTGCAGAGCTAAGACCAAACCAGGGGACACTGTCGCTGTTTACC
AACGAGGCTGGAGGCATCTTAGATGACTTGATTGTAACCAATACTTCTGAGGGCCACCTG
TATGTGGTGTCCAACGCTGGCTGCTGGGAGAAAGATTTGGCCCTCATGCAGGACAAGGTC
AGGGAGCTTCAGAACCAGGGCAGAGATGTGGGCCTGGAGGTGTTGGATAATGCCCTGCTA
GCTCTGCAAGGCCCCACTGCAGCCCAGGTACTACAGGCCGGCGTGGCAGATGACCTGAGG
AAACTGCCCTTCATGACCAGTGCTGTGATGGAGGTGTTTGGCGTGTCTGGCTGCCGCGTG
ACCCGCTGTGGCTACACAGGAGAGGATGGTGTGGAGATCTCGGTGCCGGTAGCGGGGGCA
GTTCACCTGGCAACAGCTATTCTGAAAAACCCAGAGGTGAAGCTGGCAGGGCTGGCAGCC
AGGGACAGCCTGCGCCTGGAGGCAGGCCTCTGCCTGTATGGGAATGACATTGATGAACAC
ACTACACCTGTGGAGGGCAGCCTCAGTTGGACACTGGGGAAGCGCCGCCGAGCTGCTATG
GACTTCCCTGGAGCCAAGGTCATTGTTCCCCAGCTGAAGGGCAGGGTGCAGCGGAGGCGT
GTGGGGTTGATGTGTGAGGGGGCCCCCATGCGGGCACACAGTCCCATCCTGAACATGGAG
GGTACCAAGATTGGTACTGTGACTAGTGGCTGCCCCTCCCCCTCTCTGAAGAAGAATGTG
GCGATGGGTTATGTGCCCTGCGAGTACAGTCGTCCAGGGACAATGCTGCTGGTAGAGGTG
CGGCGGAAGCAGCAGATGGCTGTAGTCAGCAAGATGCCCTTTGTGCCCACAAACTACTAT
ACCCTCAAGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 403 |
| Molecular Weight
| 43945.65 |
| Theoretical pI
| 8.566 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Aminomethyltransferase, mitochondrial
MQRAVSVVARLGFRLQAFPPALCRPLSCAQEVLRRTPLYDFHLAHGGKMVAFAGWSLPVQ
YRDSHTDSHLHTRQHCSLFDVSHMLQTKILGSDRVKLMESLVVGDIAELRPNQGTLSLFT
NEAGGILDDLIVTNTSEGHLYVVSNAGCWEKDLALMQDKVRELQNQGRDVGLEVLDNALL
ALQGPTAAQVLQAGVADDLRKLPFMTSAVMEVFGVSGCRVTRCGYTGEDGVEISVPVAGA
VHLATAILKNPEVKLAGLAARDSLRLEAGLCLYGNDIDEHTTPVEGSLSWTLGKRRRAAM
DFPGAKVIVPQLKGRVQRRRVGLMCEGAPMRAHSPILNMEGTKIGTVTSGCPSPSLKKNV
AMGYVPCEYSRPGTMLLVEVRRKQQMAVVSKMPFVPTNYYTLK
|
| External Links |
|---|
| GenBank ID Protein
| 158254632 |
| UniProtKB/Swiss-Prot ID
| P48728 |
| UniProtKB/Swiss-Prot Entry Name
| GCST_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| AK290600 |
| GeneCard ID
| AMT |
| GenAtlas ID
| AMT |
| HGNC ID
| HGNC:473 |
| References |
|---|
| General References
| Not Available |