| Identification |
|---|
| HMDB Protein ID
| CDBP00647 |
| Secondary Accession Numbers
| Not Available |
| Name
| Histidine ammonia-lyase |
| Description
| Not Available |
| Synonyms
|
- Histidase
|
| Gene Name
| HAL |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in histidine ammonia-lyase activity |
| Specific Function
| Not Available |
| GO Classification
|
| Biological Process |
| histidine catabolic process to glutamate and formamide |
| histidine catabolic process to glutamate and formate |
| biosynthetic process |
| histidine catabolic process |
| Cellular Component |
| cytosol |
| Component |
| cell part |
| intracellular part |
| cytoplasm |
| Function |
| catalytic activity |
| lyase activity |
| carbon-nitrogen lyase activity |
| ammonia-lyase activity |
| histidine ammonia-lyase activity |
| Molecular Function |
| histidine ammonia-lyase activity |
| Process |
| metabolic process |
| cellular metabolic process |
| biosynthetic process |
| cellular amino acid and derivative metabolic process |
| cellular amino acid metabolic process |
| histidine family amino acid metabolic process |
| histidine metabolic process |
| histidine catabolic process |
|
| Cellular Location
|
Not Available
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | L-histidine degradation into L-glutamate | Not Available | Not Available | | Ammonia Recycling |    |  | | Histidine Metabolism |    |  | | Histidinemia |    | Not Available |
|
| Gene Properties |
|---|
| Chromosome Location
| 12 |
| Locus
| 12q22-q24.1 |
| SNPs
| HAL |
| Gene Sequence
|
>1974 bp
ATGCCCAGATACACGGTGCACGTACGTGGGGAATGGCTGGCAGTGCCCTGCCAGGACGCG
CAGCTCACTGTGGGCTGGCTGGGCCGGGAGGCCGTGAGGCGCTATATCAAGAATAAGCCC
GACAATGGTGGCTTCACCTCCGTGGATGACGCGCACTTCCTTGTGCGCCGGTGCAAGGGC
CTGGGCCTGCTGGACAACGAGGACCGGCTCGAGGTGGCCCTAGAGAACAACGAGTTCGTG
GAAGTGGTTATAGAGGGTGATGCCATGTCTCCTGACTTCATTCCATCTCAACCAGAAGGA
GTTTATCTATACAGCAAGTACCGGGAGCCTGAAAAGTACATCGAGTTAGATGGAGACCGT
CTGACCACGGAGGATCTGGTCAACTTGGGAAAGGGACGCTACAAAATAAAGCTCACCCCA
ACAGCTGAGAAGAGGGTGCAGAAATCCAGGGAGGTCATAGATAGCATCATAAAAGAGAAA
ACAGTTGTTTACGGTATTACTACAGGTTTTGGGAAATTTGCCAGAACTGTAATTCCTATC
AATAAGCTACAGGAGCTTCAGGTCAACTTAGTACGCTCACATTCTTCAGGTGTTGGGAAA
CCACTAAGTCCTGAGAGGTGTCGGATGCTCTTGGCTTTAAGGATCAATGTCTTAGCCAAA
GGATACAGTGGCATTTCCCTGGAGACCCTCAAACAAGTCATAGAAATGTTTAATGCCTCC
TGCCTGCCCTATGTCCCAGAGAAAGGAACCGTTGGTGCCAGTGGAGACCTTGCCCCACTC
TCTCATCTTGCTCTTGGGCTAGTTGGAGAAGGGAAGATGTGGTCTCCGAAGAGTGGCTGG
GCTGATGCTAAATACGTGCTAGAAGCCCATGGATTGAAACCAGTTATTTTAAAACCAAAA
GAGGGCCTGGCACTCATCAATGGGACGCAGATGATCACATCCCTGGGCTGTGAAGCTGTA
GAGCGAGCCAGTGCTATTGCACGGCAGGCTGACATTGTGGCAGCCCTGACCCTTGAGGTG
CTGAAGGGCACCACCAAAGCCTTTGACACTGACATTCATGCTCTTCGACCTCACCGTGGG
CAAATTGAAGTTGCTTTTCGGTTTCGGTCACTCTTGGACTCAGATCACCACCCATCAGAA
ATAGCAGAGAGTCACAGGTTCTGTGATCGCGTCCAGGATGCATACACCTTGCGCTGCTGT
CCACAGGTCCATGGTGTGGTGAATGATACAATAGCATTTGTGAAGAACATCATTACCACA
GAACTGAACAGCGCAACAGATAATCCTATGGTCTTTGCCAATAGGGGAGAGACAGTTTCT
GGAGGAAACTTCCATGGTGAATACCCAGCCAAAGCCCTAGACTACTTGGCCATTGGCATC
CATGAACTTGCTGCAATCAGTGAGAGAAGAATCGAGCGGCTCTGCAATCCCTCCCTCAGT
GAGCTGCCTGCCTTCCTGGTGGCTGAAGGTGGTCTGAACTCTGGGTTCATGATAGCTCAC
TGCACGGCAGCAGCCCTTGTTTCTGAGAACAAGGCTCTGTGCCATCCCTCGTCTGTTGAC
TCCCTCTCCACCAGCGCAGCCACGGAGGACCACGTCTCCATGGGAGGATGGGCAGCAAGG
AAAGCCCTCAGGGTCATCGAGCATGTGGAGCAAGTGCTGGCCATCGAGCTCCTTGCAGCC
TGCCAGGGCATAGAGTTTCTACGTCCCCTGAAAACAACCACTCCGCTGGAGAAGGTCTAT
GACCTGGTGCGCTCTGTTGTAAGGCCCTGGATAAAAGATCGCTTCATGGCCCCGGACATC
GAGGCAGCCCACAGGCTGCTCCTGGAGCAGAAGGTTTGGGAAGTAGCTGCTCCATACATT
GAAAAATACAGAATGGAGCATATTCCAGAATCAAGACCTCTTTCTCCAACAGCCTTTTCA
CTGCAATTTCTGCACAAGAAATCCACCAAAATCCCGGAGTCTGAGGACCTTTAA
|
| Protein Properties |
|---|
| Number of Residues
| 657 |
| Molecular Weight
| 49122.09 |
| Theoretical pI
| 6.665 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Histidine ammonia-lyase
MPRYTVHVRGEWLAVPCQDAQLTVGWLGREAVRRYIKNKPDNGGFTSVDDAHFLVRRCKG
LGLLDNEDRLEVALENNEFVEVVIEGDAMSPDFIPSQPEGVYLYSKYREPEKYIELDGDR
LTTEDLVNLGKGRYKIKLTPTAEKRVQKSREVIDSIIKEKTVVYGITTGFGKFARTVIPI
NKLQELQVNLVRSHSSGVGKPLSPERCRMLLALRINVLAKGYSGISLETLKQVIEMFNAS
CLPYVPEKGTVGASGDLAPLSHLALGLVGEGKMWSPKSGWADAKYVLEAHGLKPVILKPK
EGLALINGTQMITSLGCEAVERASAIARQADIVAALTLEVLKGTTKAFDTDIHALRPHRG
QIEVAFRFRSLLDSDHHPSEIAESHRFCDRVQDAYTLRCCPQVHGVVNDTIAFVKNIITT
ELNSATDNPMVFANRGETVSGGNFHGEYPAKALDYLAIGIHELAAISERRIERLCNPSLS
ELPAFLVAEGGLNSGFMIAHCTAAALVSENKALCHPSSVDSLSTSAATEDHVSMGGWAAR
KALRVIEHVEQVLAIELLAACQGIEFLRPLKTTTPLEKVYDLVRSVVRPWIKDRFMAPDI
EAAHRLLLEQKVWEVAAPYIEKYRMEHIPESRPLSPTAFSLQFLHKKSTKIPESEDL
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| P42357 |
| UniProtKB/Swiss-Prot Entry Name
| HUTH_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| D16626 |
| GeneCard ID
| HAL |
| GenAtlas ID
| HAL |
| HGNC ID
| HGNC:4806 |
| References |
|---|
| General References
| Not Available |