Cannabis Compound Database: Showing Protein Ubiquitin-conjugating enzyme E2 C (CDBP00615)

Identification Biological properties Gene properties Protein properties External links References XML Show 3 compounds

Identification

HMDB Protein ID

CDBP00615

Secondary Accession Numbers

Not Available

Name

Ubiquitin-conjugating enzyme E2 C

Description

Not Available

Synonyms

UbcH10
Ubiquitin carrier protein C
Ubiquitin-protein ligase C

Gene Name

UBE2C

Protein Type

Enzyme

Biological Properties

General Function

Involved in ubiquitin-protein ligase activity

Specific Function

Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by initiating 'Lys-11'-linked polyubiquitin chains on APC/C substrates, leading to the degradation of APC/C substrates by the proteasome and promoting mitotic exit.

GO Classification

Biological Process
mitotic cell cycle spindle assembly checkpoint
negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
protein K48-linked ubiquitination
protein K11-linked ubiquitination
cyclin catabolic process
free ubiquitin chain polymerization
positive regulation of exit from mitosis
spindle organization
phosphatidylinositol-mediated signaling
exit from mitosis
mitosis
cell division
activation of anaphase-promoting complex activity
anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
Cellular Component
cytosol
nucleoplasm
anaphase-promoting complex
Function
catalytic activity
small conjugating protein ligase activity
nucleoside binding
purine nucleoside binding
adenyl nucleotide binding
adenyl ribonucleotide binding
atp binding
ligase activity
ligase activity, forming carbon-nitrogen bonds
acid-amino acid ligase activity
ubiquitin-protein ligase activity
binding
Molecular Function
ubiquitin-protein ligase activity
ATP binding
Process
biological regulation
regulation of biological process
regulation of metabolic process
regulation of macromolecule metabolic process
post-translational protein modification
protein modification by small protein conjugation or removal
protein modification by small protein conjugation
protein ubiquitination
macromolecule modification
protein modification process
metabolic process
regulation of protein metabolic process
macromolecule metabolic process

Cellular Location

Not Available

Pathways

Name	SMPDB/Pathwhiz	KEGG
protein ubiquitination	Not Available	Not Available
Ubiquitin mediated proteolysis	Not Available

Gene Properties

Chromosome Location

Locus

20q13.12

SNPs

UBE2C

Gene Sequence

>540 bp
ATGGCTTCCCAAAACCGCGACCCAGCCGCCACTAGCGTCGCCGCCGCCCGTAAAGGAGCT
GAGCCGAGCGGGGGCGCCGCCCGGGGTCCGGTGGGCAAAAGGCTACAGCAGGAGCTGATG
ACCCTCATGATGTCTGGCGATAAAGGGATTTCTGCCTTCCCTGAATCAGACAACCTTTTC
AAATGGGTAGGGACCATCCATGGAGCAGCTGGAACAGTATATGAAGACCTGAGGTATAAG
CTCTCGCTAGAGTTCCCCAGTGGCTACCCTTACAATGCGCCCACAGTGAAGTTCCTCACG
CCCTGCTATCACCCCAACGTGGACACCCAGGGTAACATATGCCTGGACATCCTGAAGGAA
AAGTGGTCTGCCCTGTATGATGTCAGGACCATTCTGCTCTCCATCCAGAGCCTTCTAGGA
GAACCCAACATTGATAGTCCCTTGAACACACATGCTGCCGAGCTCTGGAAAAACCCCACA
GCTTTTAAGAAGTACCTGCAAGAAACCTACTCAAAGCAGGTCACCAGCCAGGAGCCCTGA

Protein Properties

Number of Residues

179

Molecular Weight

19652.13

Theoretical pI

7.371

Pfam Domain Function

UQ_con (PF00179 )

Signals

Not Available

Transmembrane Regions

Not Available

Protein Sequence

>Ubiquitin-conjugating enzyme E2 C
MASQNRDPAATSVAAARKGAEPSGGAARGPVGKRLQQELMTLMMSGDKGISAFPESDNLF
KWVGTIHGAAGTVYEDLRYKLSLEFPSGYPYNAPTVKFLTPCYHPNVDTQGNICLDILKE
KWSALYDVRTILLSIQSLLGEPNIDSPLNTHAAELWKNPTAFKKYLQETYSKQVTSQEP

External Links

GenBank ID Protein

5902146

UniProtKB/Swiss-Prot ID

O00762

UniProtKB/Swiss-Prot Entry Name

UBE2C_HUMAN

PDB IDs