| Identification |
|---|
| HMDB Protein ID
| CDBP00606 |
| Secondary Accession Numbers
| Not Available |
| Name
| Adenosine kinase |
| Description
| Not Available |
| Synonyms
|
- AK
- Adenosine 5'-phosphotransferase
|
| Gene Name
| ADK |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in adenosine kinase activity |
| Specific Function
| ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives. Serves as a potential regulator of concentrations of extracellular adenosine and intracellular adenine nucleotides.
|
| GO Classification
|
| Biological Process |
| adenosine metabolic process |
| purine nucleobase metabolic process |
| AMP salvage |
| dATP biosynthetic process |
| positive regulation of T cell proliferation |
| purine ribonucleoside salvage |
| purine-containing compound salvage |
| Cellular Component |
| cytosol |
| nucleus |
| Function |
| nucleobase, nucleoside, nucleotide kinase activity |
| nucleoside kinase activity |
| adenosine kinase activity |
| catalytic activity |
| transferase activity |
| transferase activity, transferring phosphorus-containing groups |
| kinase activity |
| Molecular Function |
| metal ion binding |
| adenosine kinase activity |
| phosphotransferase activity, alcohol group as acceptor |
| ATP binding |
| Process |
| metabolic process |
| biosynthetic process |
| cellular biosynthetic process |
| heterocycle biosynthetic process |
| purine salvage |
| purine ribonucleoside salvage |
|
| Cellular Location
|
Not Available
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | AMP biosynthesis via salvage pathway | Not Available | Not Available | | Mercaptopurine Action Pathway |    | Not Available | | Mercaptopurine Metabolism Pathway |    | Not Available | | Thioguanine Action Pathway |    | Not Available | | Azathioprine Action Pathway |    | Not Available |
|
| Gene Properties |
|---|
| Chromosome Location
| 10 |
| Locus
| 10q11-q24 |
| SNPs
| ADK |
| Gene Sequence
|
>1089 bp
ATGGCAGCTGCTGAGGAGGAGCCGAAGCCCAAAAAGCTGAAGGTGGAGGCGCCGCAAGCG
CTGAGAGAAAATATTCTCTTTGGAATGGGAAATCCTCTGCTTGACATCTCTGCTGTAGTG
GACAAAGATTTCCTTGATAAGTATTCTCTGAAACCAAATGACCAAATCTTGGCTGAAGAC
AAACACAAGGAACTGTTTGATGAACTTGTGAAAAAATTCAAAGTCGAATATCATGCTGGT
GGCTCTACCCAGAATTCAATTAAAGTGGCTCAGTGGATGATTCAACAGCCACACAAAGCA
GCAACATTTTTTGGATGCATTGGGATAGATAAATTTGGGGAGATCCTGAAGAGAAAAGCT
GCTGAAGCCCATGTGGATGCTCATTACTACGAGCAGAATGAGCAGCCAACAGGAACTTGT
GCTGCATGCATCACTGGTGACAACAGGTCCCTCATAGCTAATCTTGCTGCTGCCAATTGT
TATAAAAAGGAAAAACATCTTGATCTGGAGAAAAACTGGATGTTGGTAGAAAAAGCAAGA
GTTTGTTATATAGCAGGCTTTTTTCTTACAGTTTCCCCAGAGTCAGTATTAAAGGTGGCT
CACCATGCTTCTGAAAACAACAGGATTTTCACTTTGAATCTATCTGCACCGTTTATTAGC
CAGTTCTACAAGGAATCATTGATGAAAGTTATGCCTTATGTTGATATACTTTTTGGAAAT
GAGACAGAAGCTGCCACTTTTGCTAGAGAGCAAGGCTTTGAGACTAAAGACATTAAAGAG
ATAGCCAAAAAGACACAAGCCCTGCCAAAGATGAACTCAAAGAGGCAGCGAATCGTGATC
TTCACCCAAGGGAGAGATGACACTATAATGGCTACAGAAAGTGAAGTCACTGCTTTTGCT
GTCTTGGATCAAGACCAGAAAGAAATTATTGATACCAATGGAGCTGGAGATGCATTTGTT
GGAGGTTTTCTGTCTCAACTGGTCTCTGACAAGCCTCTGACTGAATGTATCCGTGCTGGC
CACTATGCAGCAAGCATCATAATTAGACGGACTGGCTGCACCTTTCCTGAGAAGCCAGAC
TTCCACTGA
|
| Protein Properties |
|---|
| Number of Residues
| 362 |
| Molecular Weight
| 38702.93 |
| Theoretical pI
| 6.688 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Adenosine kinase
MAAAEEEPKPKKLKVEAPQALRENILFGMGNPLLDISAVVDKDFLDKYSLKPNDQILAED
KHKELFDELVKKFKVEYHAGGSTQNSIKVAQWMIQQPHKAATFFGCIGIDKFGEILKRKA
AEAHVDAHYYEQNEQPTGTCAACITGDNRSLIANLAAANCYKKEKHLDLEKNWMLVEKAR
VCYIAGFFLTVSPESVLKVAHHASENNRIFTLNLSAPFISQFYKESLMKVMPYVDILFGN
ETEAATFAREQGFETKDIKEIAKKTQALPKMNSKRQRIVIFTQGRDDTIMATESEVTAFA
VLDQDQKEIIDTNGAGDAFVGGFLSQLVSDKPLTECIRAGHYAASIIIRRTGCTFPEKPD
FH
|
| External Links |
|---|
| GenBank ID Protein
| 32484975 |
| UniProtKB/Swiss-Prot ID
| P55263 |
| UniProtKB/Swiss-Prot Entry Name
| ADK_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| NM_006721 |
| GeneCard ID
| ADK |
| GenAtlas ID
| ADK |
| HGNC ID
| HGNC:257 |
| References |
|---|
| General References
| Not Available |