Cannabis Compound Database: Showing Protein Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma (CDBP00604)

Identification Biological properties Gene properties Protein properties External links References XML Show 3 compounds

Identification

HMDB Protein ID

CDBP00604

Secondary Accession Numbers

Not Available

Name

Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma

Description

Not Available

Synonyms

GMP-PDE gamma

Gene Name

PDE6G

Protein Type

Enzyme

Biological Properties

General Function

Involved in 3',5'-cyclic-nucleotide phosphodiesterase activity

Specific Function

Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones.

GO Classification

Biological Process
blood coagulation
visual perception
activation of MAPK activity
positive regulation of epidermal growth factor receptor signaling pathway
positive regulation of G-protein coupled receptor protein signaling pathway
Cellular Component
cytosol
Function
cgmp binding
cyclic-nucleotide phosphodiesterase activity
3',5'-cyclic-nucleotide phosphodiesterase activity
nucleoside binding
purine nucleoside binding
phosphoric ester hydrolase activity
phosphoric diester hydrolase activity
hydrolase activity, acting on ester bonds
binding
catalytic activity
hydrolase activity
gmp binding
Molecular Function
3',5'-cyclic-GMP phosphodiesterase activity
cGMP binding
enzyme inhibitor activity
Process
multicellular organismal process
system process
neurological system process
sensory perception
sensory perception of light stimulus
visual perception

Cellular Location

Cytoplasmic

Pathways

Name	SMPDB/Pathwhiz	KEGG
Phototransduction	Not Available

Gene Properties

Chromosome Location

Locus

17q25

SNPs

PDE6G

Gene Sequence

>264 bp
ATGAACCTGGAACCGCCCAAGGCTGAGTTCCGGTCAGCCACCAGGGTGGCCGGGGGACCT
GTCACCCCCAGGAAAGGGCCCCCTAAATTTAAGCAGCGACAGACCAGGCAGTTCAAGAGC
AAGCCCCCAAAGAAAGGCGTTCAAGGGTTTGGGGACGACATCCCTGGAATGGAAGGCCTG
GGAACAGACATCACAGTCATCTGCCCTTGGGAGGCCTTCAACCACCTGGAGCTGCACGAG
CTGGCCCAATATGGCATCATCTAG

Protein Properties

Number of Residues

Molecular Weight

9643.09

Theoretical pI

9.487

Pfam Domain Function

PDE6_gamma (PF04868 )

Signals

Not Available

Transmembrane Regions

Not Available

Protein Sequence

>Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma
MNLEPPKAEFRSATRVAGGPVTPRKGPPKFKQRQTRQFKSKPPKKGVQGFGDDIPGMEGL
GTDITVICPWEAFNHLELHELAQYGII

External Links

GenBank ID Protein

Not Available

UniProtKB/Swiss-Prot ID

P18545

UniProtKB/Swiss-Prot Entry Name

CNRG_HUMAN

PDB IDs