Cannabis Compound Database: Showing Protein Ribose-phosphate pyrophosphokinase 2 (CDBP00599)

Identification Biological properties Gene properties Protein properties External links References XML Show 7 compounds

Identification

HMDB Protein ID

CDBP00599

Secondary Accession Numbers

Not Available

Name

Ribose-phosphate pyrophosphokinase 2

Description

Not Available

Synonyms

PPRibP
PRS-II
Phosphoribosyl pyrophosphate synthase II

Gene Name

PRPS2

Protein Type

Enzyme

Biological Properties

General Function

Involved in magnesium ion binding

Specific Function

Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis.

GO Classification

Biological Process
AMP biosynthetic process
nucleobase-containing compound metabolic process
organ regeneration
5-phosphoribose 1-diphosphate biosynthetic process
Cellular Component
protein complex
Function
ion binding
cation binding
metal ion binding
binding
catalytic activity
transferase activity
transferase activity, transferring phosphorus-containing groups
diphosphotransferase activity
ribose phosphate diphosphokinase activity
magnesium ion binding
Molecular Function
ATP binding
AMP binding
protein homodimerization activity
GDP binding
ADP binding
magnesium ion binding
kinase activity
ribose phosphate diphosphokinase activity
Process
nucleoside metabolic process
biosynthetic process
cellular biosynthetic process
metabolic process
nitrogen compound metabolic process
cellular nitrogen compound metabolic process
nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
nucleobase, nucleoside and nucleotide metabolic process
nucleoside phosphate metabolic process
nucleotide metabolic process
nucleotide biosynthetic process
nucleoside monophosphate metabolic process
nucleoside monophosphate biosynthetic process
ribonucleoside monophosphate biosynthetic process

Cellular Location

Not Available

Pathways

Name	SMPDB/Pathwhiz	KEGG
5-phospho-alpha-D-ribose 1-diphosphate biosynthesis	Not Available	Not Available

Gene Properties

Chromosome Location

Locus

Xp22.2

SNPs

PRPS2

Gene Sequence

>957 bp
ATGCCCAACATCGTGCTGTTCAGCGGCAGCTCGCATCAGGACCTGTCCCAGCGCGTGGCC
GACCGCCTGGGCCTGGAGCTGGGCAAGGTGGTCACGAAGAAGTTCAGCAACCAGGAGACC
AGCGTGGAGATTGGTGAAAGCGTGAGAGGGGAAGATGTCTACATCATCCAGAGCGGCTGC
GGGGAAATTAACGACAACCTGATGGAACTCCTCATCATGATCAATGCCTGCAAGATTGCG
TCATCATCCAGAGTAACTGCCGTGATCCCGTGTTTCCCATACGCCCGACAAGATAAAAAG
GACAAGAGTCGTGCCCCAATTTCTGCAAAACTTGTGGCCAATATGCTGTCGGTGGCTGGG
GCGGATCACATCATCACCATGGACCTGCATGCTTCTCAGATACAGGGATTCTTTGATATT
CCTGTGGATAATTTGTATGCGGAGCCCGCAGTCCTGCAGTGGATTCGGGAAAACATTGCC
GAGTGGAAGAACTGTATCATTGTTTCACCTGACGCAGGGGGAGCCAAAAGGGTTACATCA
ATTGCAGACAGGTTGAATGTGGAATTTGCTTTGATCCACAAAGAGAGGAAGAAGGCGAAT
GAAGTGGACCGGATGGTCCTGGTGGGCGACGTGAAGGACCGTGTGGCCATCCTCGTGGAT
GACATGGCTGACACTTGCGGCACCATCTGCCATGCTGCGGACAAGCTGCTGTCAGCTGGA
GCCACCAAAGTGTATGCTATCCTTACCCATGGGATCTTCTCTGGACCAGCTATTTCCAGA
ATAAATAATGCCGCCTTTGAGGCTGTTGTCGTCACAAACACAATTCCGCAAGAGGACAAA
ATGAAACACTGCACCAAGATTCAGGTCATTGACATTTCCATGATCTTGGCCGAAGCAATC
CGAAGGACACACAATGGGGAATCCGTGTCCTACCTGTTCAGCCATGTCCCGCTATAA

Protein Properties

Number of Residues

318

Molecular Weight

35054.06

Theoretical pI

6.451

Pfam Domain Function

Pribosyltran (PF00156 )

Signals

Not Available

Transmembrane Regions

Not Available

Protein Sequence

>Ribose-phosphate pyrophosphokinase 2
MPNIVLFSGSSHQDLSQRVADRLGLELGKVVTKKFSNQETSVEIGESVRGEDVYIIQSGC
GEINDNLMELLIMINACKIASSSRVTAVIPCFPYARQDKKDKSRAPISAKLVANMLSVAG
ADHIITMDLHASQIQGFFDIPVDNLYAEPAVLQWIRENIAEWKNCIIVSPDAGGAKRVTS
IADRLNVEFALIHKERKKANEVDRMVLVGDVKDRVAILVDDMADTCGTICHAADKLLSAG
ATKVYAILTHGIFSGPAISRINNAAFEAVVVTNTIPQEDKMKHCTKIQVIDISMILAEAI
RRTHNGESVSYLFSHVPL

External Links

GenBank ID Protein

4506129

UniProtKB/Swiss-Prot ID

P11908

UniProtKB/Swiss-Prot Entry Name

PRPS2_HUMAN

PDB IDs

Not Available

GenBank Gene ID

NM_002765.4

GeneCard ID