| Identification |
|---|
| HMDB Protein ID
| CDBP00594 |
| Secondary Accession Numbers
| Not Available |
| Name
| ADP-sugar pyrophosphatase |
| Description
| Not Available |
| Synonyms
|
- Nucleoside diphosphate-linked moiety X motif 5
- Nudix motif 5
- YSA1H
- 8-oxo-dGDP phosphatase
|
| Gene Name
| NUDT5 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in hydrolase activity |
| Specific Function
| Hydrolyzes with similar activities ADP-ribose ADP-mannose, ADP-glucose, 8-oxo-GDP and 8-oxo-dGDP. Can also hydrolyze other nucleotide sugars with low activity.
|
| GO Classification
|
| Biological Process |
| nucleotide metabolic process |
| D-ribose catabolic process |
| ribonucleoside diphosphate catabolic process |
| Cellular Component |
| intracellular |
| Function |
| catalytic activity |
| hydrolase activity |
| Molecular Function |
| magnesium ion binding |
| ADP-sugar diphosphatase activity |
| snoRNA binding |
| nucleoside-diphosphatase activity |
| ADP-ribose diphosphatase activity |
|
| Cellular Location
|
- Cytoplasmic
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Purine Metabolism |    |  | | Adenosine Deaminase Deficiency |    | Not Available | | Adenylosuccinate Lyase Deficiency |    | Not Available | | Gout or Kelley-Seegmiller Syndrome |    | Not Available | | Lesch-Nyhan Syndrome (LNS) |    | Not Available |
|
| Gene Properties |
|---|
| Chromosome Location
| 10 |
| Locus
| 10p14 |
| SNPs
| NUDT5 |
| Gene Sequence
|
>660 bp
ATGGAGAGCCAAGAACCAACGGAATCTTCTCAGAATGGCAAACAGTATATCATTTCAGAG
GAGTTAATTTCAGAAGGAAAATGGGTCAAGCTTGAAAAAACAACGTACATGGATCCTACT
GGTAAAACTAGAACTTGGGAATCAGTGAAACGTACAACCAGGAAAGAGCAGACTGCGGAT
GGTGTCGCGGTCATCCCCGTGCTGCAGAGAACACTTCACTATGAGTGTATCGTTCTGGTG
AAACAGTTCCGACCACCAATGGGGGGCTACTGCATAGAGTTCCCTGCAGGTCTCATAGAT
GATGGTGAAACCCCAGAAGCAGCTGCTCTCCGGGAGCTTGAAGAAGAAACTGGCTACAAA
GGGGACATTGCCGAATGTTCTCCAGCGGTCTGTATGGACCCAGGCTTGTCAAACTGTACT
ATACACATCGTGACAGTCACCATTAACGGAGATGATGCCGAAAACGCAAGGCCGAAGCCA
AAGCCAGGGGATGGAGAGTTTGTGGAAGTCATTTCTTTACCCAAGAATGACCTGCTGCAG
AGACTTGATGCTCTGGTAGCTGAAGAACATCTCACAGTGGACGCCAGGGTCTATTCCTAC
GCTCTAGCGCTGAAACATGCAAATGCAAAGCCATTTGAAGTGCCCTTCTTGAAATTTTAA
|
| Protein Properties |
|---|
| Number of Residues
| 219 |
| Molecular Weight
| 24327.41 |
| Theoretical pI
| 4.937 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>ADP-sugar pyrophosphatase
MESQEPTESSQNGKQYIISEELISEGKWVKLEKTTYMDPTGKTRTWESVKRTTRKEQTAD
GVAVIPVLQRTLHYECIVLVKQFRPPMGGYCIEFPAGLIDDGETPEAAALRELEEETGYK
GDIAECSPAVCMDPGLSNCTIHIVTVTINGDDAENARPKPKPGDGEFVEVISLPKNDLLQ
RLDALVAEEHLTVDARVYSYALALKHANAKPFEVPFLKF
|
| External Links |
|---|
| GenBank ID Protein
| 6288769 |
| UniProtKB/Swiss-Prot ID
| Q9UKK9 |
| UniProtKB/Swiss-Prot Entry Name
| NUDT5_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| AF155832 |
| GeneCard ID
| NUDT5 |
| GenAtlas ID
| NUDT5 |
| HGNC ID
| HGNC:8052 |
| References |
|---|
| General References
| Not Available |