Cannabis Compound Database: Showing Protein Ubiquitin-conjugating enzyme E2 E1 (CDBP00587)

Identification Biological properties Gene properties Protein properties External links References XML Show 3 compounds

Identification

HMDB Protein ID

CDBP00587

Secondary Accession Numbers

Not Available

Name

Ubiquitin-conjugating enzyme E2 E1

Description

Not Available

Synonyms

UbcH6
Ubiquitin carrier protein E1
Ubiquitin-protein ligase E1

Gene Name

UBE2E1

Protein Type

Enzyme

Biological Properties

General Function

Involved in acid-amino acid ligase activity

Specific Function

Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes the covalent attachment of ISG15 to other proteins. Mediates the selective degradation of short-lived and abnormal proteins. In vitro also catalyzes 'Lys-48'-linked polyubiquitination.

GO Classification

Biological Process
cytokine-mediated signaling pathway
anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
mitotic cell cycle spindle assembly checkpoint
negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
protein K48-linked ubiquitination
histone H2B ubiquitination
histone monoubiquitination
ISG15-protein conjugation
Cellular Component
cytosol
nucleoplasm
ubiquitin ligase complex
Function
catalytic activity
small conjugating protein ligase activity
ligase activity
ligase activity, forming carbon-nitrogen bonds
acid-amino acid ligase activity
Molecular Function
ubiquitin-protein ligase activity
ATP binding
ISG15 ligase activity
Process
regulation of biological process
regulation of metabolic process
regulation of macromolecule metabolic process
post-translational protein modification
macromolecule modification
protein modification process
metabolic process
regulation of protein metabolic process
macromolecule metabolic process
biological regulation

Cellular Location

Nucleus

Pathways

Name	SMPDB/Pathwhiz	KEGG
protein ubiquitination	Not Available	Not Available
Ubiquitin mediated proteolysis	Not Available
Protein processing in endoplasmic reticulum	Not Available

Gene Properties

Chromosome Location

Locus

3p24.2

SNPs

UBE2E1

Gene Sequence

>582 bp
ATGTCGGATGACGATTCGAGGGCCAGCACCAGCTCCTCCTCATCTTCGTCTTCCAACCAG
CAAACCGAGAAAGAAACAAACACCCCCAAGAAGAAGGAGAGTAAAGTCAGCATGAGCAAA
AACTCCAAACTCCTCTCCACCAGCGCCAAGAGAATTCAGAAGGAGCTGGCGGACATCACT
TTAGACCCTCCACCTAATTGCAGTGCTGGTCCCAAAGGCGATAACATCTATGAATGGAGA
TCAACCATTCTAGGGCCTCCAGGATCCGTGTATGAGGGTGGTGTATTCTTTCTCGATATC
ACTTTTACACCAGAATATCCCTTCAAGCCTCCAAAGGTTACATTTCGGACAAGAATCTAT
CATTGTAATATTAACAGTCAAGGTGTTATTTGCTTGGACATATTGAAAGATAATTGGAGT
CCAGCACTAACCATTTCTAAAGTCCTCCTTTCTATCTGCTCACTTCTTACAGACTGTAAT
CCTGCCGACCCCTTGGTGGGAAGTATTGCCACTCAGTATATGACCAACAGAGCAGAACAT
GACAGAATGGCCAGACAGTGGACCAAGAGATACGCTACATAA

Protein Properties

Number of Residues

193

Molecular Weight

21403.93

Theoretical pI

8.524

Pfam Domain Function

UQ_con (PF00179 )

Signals

Not Available

Transmembrane Regions

Not Available

Protein Sequence

>Ubiquitin-conjugating enzyme E2 E1
MSDDDSRASTSSSSSSSSNQQTEKETNTPKKKESKVSMSKNSKLLSTSAKRIQKELADIT
LDPPPNCSAGPKGDNIYEWRSTILGPPGSVYEGGVFFLDITFTPEYPFKPPKVTFRTRIY
HCNINSQGVICLDILKDNWSPALTISKVLLSICSLLTDCNPADPLVGSIATQYMTNRAEH
DRMARQWTKRYAT

External Links

GenBank ID Protein

189054583

UniProtKB/Swiss-Prot ID

P51965

UniProtKB/Swiss-Prot Entry Name

UB2E1_HUMAN

PDB IDs