| Identification |
|---|
| HMDB Protein ID
| CDBP00534 |
| Secondary Accession Numbers
| Not Available |
| Name
| NEDD8-conjugating enzyme Ubc12 |
| Description
| Not Available |
| Synonyms
|
- NEDD8 carrier protein
- NEDD8 protein ligase
- Ubiquitin-conjugating enzyme E2 M
|
| Gene Name
| UBE2M |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in ATP binding |
| Specific Function
| Accepts the ubiquitin-like protein NEDD8 from the UBA3-NAE1 E1 complex and catalyzes its covalent attachment to other proteins. The specific interaction with the E3 ubiquitin ligase RBX1, but not RBX2, suggests that the RBX1-UBE2M complex neddylates specific target proteins, such as CUL1, CUL2, CUL3 and CUL4. Involved in cell proliferation.
|
| GO Classification
|
| Biological Process |
| protein neddylation |
| positive regulation of neuron apoptotic process |
| Function |
| atp binding |
| ligase activity |
| ligase activity, forming carbon-nitrogen bonds |
| acid-amino acid ligase activity |
| binding |
| catalytic activity |
| small conjugating protein ligase activity |
| nucleoside binding |
| purine nucleoside binding |
| adenyl nucleotide binding |
| adenyl ribonucleotide binding |
| Molecular Function |
| ubiquitin-protein ligase activity |
| ATP binding |
| NEDD8 ligase activity |
| ribosomal S6-glutamic acid ligase activity |
| Process |
| macromolecule modification |
| protein modification process |
| metabolic process |
| regulation of protein metabolic process |
| macromolecule metabolic process |
| biological regulation |
| regulation of biological process |
| regulation of metabolic process |
| regulation of macromolecule metabolic process |
| post-translational protein modification |
|
| Cellular Location
|
Not Available
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | protein neddylation | Not Available | Not Available | | Ubiquitin mediated proteolysis | Not Available |  |
|
| Gene Properties |
|---|
| Chromosome Location
| 19 |
| Locus
| 19q13.43 |
| SNPs
| UBE2M |
| Gene Sequence
|
>552 bp
ATGATCAAGCTGTTCTCGCTGAAGCAGCAGAAGAAGGAGGAGGAGTCGGCGGGCGGCACC
AAGGGCAGCAGCAAGAAGGCGTCGGCGGCGCAGCTGCGGATCCAGAAGGACATAAACGAG
CTGAACCTGCCCAAGACGTGTGATATCAGCTTCTCAGATCCAGACGACCTCCTCAACTTC
AAGCTGGTCATCTGTCCTGATGAGGGCTTCTACAAGAGTGGGAAGTTTGTGTTCAGTTTT
AAGGTGGGCCAGGGTTACCCGCATGATCCCCCCAAGGTGAAGTGTGAGACAATGGTCTAT
CACCCCAACATTGACCTCGAGGGCAACGTCTGCCTCAACATCCTCAGAGAGGACTGGAAG
CCAGTCCTTACGATAAACTCCATAATTTATGGCCTGCAGTATCTCTTCTTGGAGCCCAAC
CCCGAGGACCCACTGAACAAGGAGGCCGCAGAGGTCCTGCAGAACAACCGGCGGCTGTTT
GAGCAGAACGTGCAGCGCTCCATGCGGGGTGGCTACATCGGCTCCACCTACTTTGAGCGC
TGCCTGAAATAG
|
| Protein Properties |
|---|
| Number of Residues
| 183 |
| Molecular Weight
| 20899.8 |
| Theoretical pI
| 7.695 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>NEDD8-conjugating enzyme Ubc12
MIKLFSLKQQKKEEESAGGTKGSSKKASAAQLRIQKDINELNLPKTCDISFSDPDDLLNF
KLVICPDEGFYKSGKFVFSFKVGQGYPHDPPKVKCETMVYHPNIDLEGNVCLNILREDWK
PVLTINSIIYGLQYLFLEPNPEDPLNKEAAEVLQNNRRLFEQNVQRSMRGGYIGSTYFER
CLK
|
| External Links |
|---|
| GenBank ID Protein
| 3599674 |
| UniProtKB/Swiss-Prot ID
| P61081 |
| UniProtKB/Swiss-Prot Entry Name
| UBC12_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| AB012191 |
| GeneCard ID
| UBE2M |
| GenAtlas ID
| UBE2M |
| HGNC ID
| HGNC:12491 |
| References |
|---|
| General References
| Not Available |