Cannabis Compound Database: Showing Protein Ubiquitin-conjugating enzyme E2 A (CDBP00531)

Identification Biological properties Gene properties Protein properties External links References XML Show 3 compounds

Identification

HMDB Protein ID

CDBP00531

Secondary Accession Numbers

Not Available

Name

Ubiquitin-conjugating enzyme E2 A

Description

Not Available

Synonyms

HR6A
RAD6 homolog A
Ubiquitin carrier protein A
Ubiquitin-protein ligase A
hHR6A

Gene Name

UBE2A

Protein Type

Enzyme

Biological Properties

General Function

Involved in acid-amino acid ligase activity

Specific Function

Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In association with the E3 enzyme BRE1 (RNF20 and/or RNF40), it plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B at 'Lys-120' to form H2BK120ub1. H2BK120ub1 gives a specific tag for epigenetic transcriptional activation, elongation by RNA polymerase II, telomeric silencing, and is also a prerequisite for H3K4me and H3K79me formation. In vitro catalyzes 'Lys-11', as well as 'Lys-48'-linked polyubiquitination. Required for postreplication repair of UV-damaged DNA.

GO Classification

Biological Process
positive regulation of cell proliferation
in utero embryonic development
protein K48-linked ubiquitination
ubiquitin-dependent protein catabolic process
protein K11-linked ubiquitination
antigen processing and presentation of peptide antigen via MHC class I
histone H2A ubiquitination
protein autoubiquitination
response to UV
postreplication repair
maternal process involved in female pregnancy
Cellular Component
HULC complex
XY body
nuclear chromatin
cytosol
Function
catalytic activity
small conjugating protein ligase activity
ligase activity
ligase activity, forming carbon-nitrogen bonds
acid-amino acid ligase activity
Molecular Function
ubiquitin-protein ligase activity
ATP binding
Process
regulation of macromolecule metabolic process
post-translational protein modification
macromolecule modification
protein modification process
metabolic process
regulation of protein metabolic process
macromolecule metabolic process
biological regulation
regulation of biological process
regulation of metabolic process

Cellular Location

Not Available

Pathways

Name	SMPDB/Pathwhiz	KEGG
protein ubiquitination	Not Available	Not Available
Ubiquitin mediated proteolysis	Not Available

Gene Properties

Chromosome Location

Locus

Xq24

SNPs

UBE2A

Gene Sequence

>459 bp
ATGTCCACCCCGGCTCGGCGGCGCCTCATGCGGGACTTCAAGAGGTTGCAGGAGGATCCT
CCAGCCGGAGTCAGCGGGGCTCCGTCCGAGAACAACATAATGGTGTGGAACGCGGTCATT
TTCGGGCCTGAAGGGACCCCGTTTGAGGATGGAACATTTAAACTTACAATAGAATTCACT
GAAGAATATCCAAATAAACCACCTACAGTTAGATTTGTCTCTAAGATGTTCCATCCAAAT
GTCTATGCAGATGGTAGTATATGTCTGGACATACTTCAGAACCGTTGGAGTCCAACCTAT
GATGTGTCTTCCATTCTAACATCCATACAGTCTCTGTTGGATGAACCCAATCCCAATAGT
CCAGCAAACAGCCAGGCTGCTCAGCTGTACCAGGAGAACAAACGGGAATATGAAAAGCGT
GTTTCTGCAATAGTAGAACAAAGCTGGCGTGATTGTTGA

Protein Properties

Number of Residues

152

Molecular Weight

17315.265

Theoretical pI

5.147

Pfam Domain Function

UQ_con (PF00179 )

Signals

Not Available

Transmembrane Regions

Not Available

Protein Sequence

>Ubiquitin-conjugating enzyme E2 A
MSTPARRRLMRDFKRLQEDPPAGVSGAPSENNIMVWNAVIFGPEGTPFEDGTFKLTIEFT
EEYPNKPPTVRFVSKMFHPNVYADGSICLDILQNRWSPTYDVSSILTSIQSLLDEPNPNS
PANSQAAQLYQENKREYEKRVSAIVEQSWRDC

External Links

GenBank ID Protein

32967280

UniProtKB/Swiss-Prot ID

P49459

UniProtKB/Swiss-Prot Entry Name

UBE2A_HUMAN

PDB IDs

Not Available

GenBank Gene ID

NM_003336.2

GeneCard ID