Cannabis Compound Database: Showing Protein Betaine--homocysteine S-methyltransferase 1 (CDBP00530)

Identification Biological properties Gene properties Protein properties External links References XML Show 6 compounds

Identification

HMDB Protein ID

CDBP00530

Secondary Accession Numbers

Not Available

Name

Betaine--homocysteine S-methyltransferase 1

Description

Not Available

Synonyms

Not Available

Gene Name

BHMT

Protein Type

Enzyme

Biological Properties

General Function

Involved in zinc ion binding

Specific Function

Involved in the regulation of homocysteine metabolism. Converts betaine and homocysteine to dimethylglycine and methionine, respectively. This reaction is also required for the irreversible oxidation of choline.

GO Classification

Biological Process
cellular nitrogen compound metabolic process
amino-acid betaine catabolic process
methionine biosynthetic process
protein methylation
regulation of homocysteine metabolic process
sulfur amino acid metabolic process
Cellular Component
cytosol
protein complex
Component
cell part
intracellular part
cytoplasm
Function
metal ion binding
binding
catalytic activity
betaine-homocysteine s-methyltransferase activity
transition metal ion binding
zinc ion binding
transferase activity
homocysteine s-methyltransferase activity
s-methyltransferase activity
transferase activity, transferring one-carbon groups
methyltransferase activity
ion binding
cation binding
Molecular Function
metal ion binding
betaine-homocysteine S-methyltransferase activity
homocysteine S-methyltransferase activity
zinc ion binding
Process
cellular metabolic process
sulfur amino acid metabolic process
sulfur amino acid biosynthetic process
methionine biosynthetic process
cellular amino acid and derivative metabolic process
cellular amino acid metabolic process
metabolic process

Cellular Location

Cytoplasm

Pathways

Name	SMPDB/Pathwhiz	KEGG
Betaine Metabolism
Glycine and Serine Metabolism
Methionine Metabolism
L-methionine biosynthesis via de novo pathway	Not Available	Not Available
betaine degradation	Not Available	Not Available

Gene Properties

Chromosome Location

Locus

5q14.1

SNPs

BHMT

Gene Sequence

>1221 bp
ATGCCACCCGTTGGGGGCAAAAAGGCCAAGAAGGGCATCCTAGAACGTTTAAATGCTGGA
GAGATTGTGATTGGAGATGGAGGGTTTGTCTTTGCACTGGAGAAGAGGGGCTACGTAAAG
GCAGGACCCTGGACTCCTGAAGCTGCTGTGGAGCACCCAGAAGCAGTTCGCCAGCTTCAT
CGAGAGTTCCTCAGAGCTGGCTCAAACGTCATGCAGACCTTCACCTTCTATGCGAGTGAA
GACAAGCTGGAGAACAGGGGCAACTATGTCTTAGAGAAGATATCTGGGCAGGAAGTCAAT
GAAGCTGCTTGCGACATCGCCCGACAAGTGGCTGATGAAGGAGATGCTTTGGTAGCAGGA
GGAGTGAGTCAGACACCTTCATACCTTAGCTGCAAGAGTGAAACTGAAGTCAAAAAAGTA
TTTCTGCAACAGTTAGAGGTCTTTATGAAGAAGAACGTGGACTTCTTGATTGCAGAGTAT
TTTGAACACGTTGAAGAAGCTGTGTGGGCAGTTGAAACCTTGATAGCATCCGGTAAACCT
GTGGCAGCAACCATGTGCATTGGCCCAGAAGGAGATTTGCATGGCGTGCCCCCCGGCGAG
TGTGCAGTGCGCCTGGTGAAAGCAGGAGCATCCATCATTGGTGTGAACTGCCACTTTGAC
CCCACCATTAGTTTAAAAACAGTGAAGCTCATGAAGGAGGGCTTGGAGGCTGCCCGACTG
AAAGCTCACCTGATGAGCCAGCCCTTGGCTTACCACACTCCTGACTGCAACAAGCAGGGA
TTCATCGATCTCCCAGAATTCCCATTTGGACTGGAACCCAGAGTTGCCACCAGATGGGAT
ATTCAAAAATACGCCAGAGAGGCCTACAACCTGGGGGTCAGGTACATTGGCGGGTGCTGT
GGATTTGAGCCCTACCACATCAGGGCAATTGCAGAGGAGCTGGCCCCAGAAAGGGGCTTT
TTGCCACCAGCTTCAGAAAAACATGGCAGCTGGGGAAGTGGTTTGGACATGCACACCAAA
CCCTGGGTTAGAGCAAGGGCCAGGAAGGAATACTGGGAGAATCTTCGGATAGCCTCAGGC
CGGCCATACAACCCTTCAATGTCAAAGCCAGATGGCTGGGGAGTGACCAAAGGAACAGCC
GAGCTGATGCAGCAGAAAGAAGCCACAACTGAGCAGCAGCTGAAAGAGCTCTTTGAAAAA
CAAAAATTCAAATCACAGTAG

Protein Properties

Number of Residues

406

Molecular Weight

44998.205

Theoretical pI

7.03

Pfam Domain Function

S-methyl_trans (PF02574 )

Signals

Not Available

Transmembrane Regions

Not Available

Protein Sequence

>Betaine--homocysteine S-methyltransferase 1
MPPVGGKKAKKGILERLNAGEIVIGDGGFVFALEKRGYVKAGPWTPEAAVEHPEAVRQLH
REFLRAGSNVMQTFTFYASEDKLENRGNYVLEKISGQEVNEAACDIARQVADEGDALVAG
GVSQTPSYLSCKSETEVKKVFLQQLEVFMKKNVDFLIAEYFEHVEEAVWAVETLIASGKP
VAATMCIGPEGDLHGVPPGECAVRLVKAGASIIGVNCHFDPTISLKTVKLMKEGLEAARL
KAHLMSQPLAYHTPDCNKQGFIDLPEFPFGLEPRVATRWDIQKYAREAYNLGVRYIGGCC
GFEPYHIRAIAEELAPERGFLPPASEKHGSWGSGLDMHTKPWVRARARKEYWENLRIASG
RPYNPSMSKPDGWGVTKGTAELMQQKEATTEQQLKELFEKQKFKSQ

External Links

GenBank ID Protein

4530461

UniProtKB/Swiss-Prot ID

Q93088

UniProtKB/Swiss-Prot Entry Name

BHMT1_HUMAN

PDB IDs