| Identification |
|---|
| HMDB Protein ID
| CDBP00525 |
| Secondary Accession Numbers
| Not Available |
| Name
| Aminoacylase-1 |
| Description
| Not Available |
| Synonyms
|
- ACY-1
- N-acyl-L-amino-acid amidohydrolase
|
| Gene Name
| ACY1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in metallopeptidase activity |
| Specific Function
| Involved in the hydrolysis of N-acylated or N-acetylated amino acids (except L-aspartate).
|
| GO Classification
|
| Biological Process |
| cellular amino acid metabolic process |
| proteolysis |
| Cellular Component |
| cytosol |
| Component |
| cell part |
| intracellular part |
| cytoplasm |
| Function |
| peptidase activity |
| peptidase activity, acting on l-amino acid peptides |
| metallopeptidase activity |
| hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides |
| binding |
| catalytic activity |
| hydrolase activity |
| aminoacylase activity |
| hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds |
| protein binding |
| Molecular Function |
| metal ion binding |
| aminoacylase activity |
| metallopeptidase activity |
| Process |
| metabolic process |
| macromolecule metabolic process |
| cellular metabolic process |
| protein metabolic process |
| proteolysis |
| cellular amino acid and derivative metabolic process |
| cellular amino acid metabolic process |
|
| Cellular Location
|
- Cytoplasm
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | 2-Oxocarboxylic acid metabolism | Not Available |  |
|
| Gene Properties |
|---|
| Chromosome Location
| 3 |
| Locus
| 3p21.1 |
| SNPs
| ACY1 |
| Gene Sequence
|
>1227 bp
ATGACCAGCAAGGGTCCCGAGGAGGAGCACCCATCGGTGACGCTCTTCCGCCAGTACCTG
CGTATCCGCACTGTCCAGCCCAAGCCTGACTATGGAGCTGCTGTGGCTTTCTTTGAGGAG
ACAGCCCGCCAGCTGGGCCTGGGCTGTCAGAAAGTAGAGGTGGCACCTGGCTATGTGGTG
ACCGTGTTGACCTGGCCAGGCACCAACCCTACACTCTCCTCCATCTTGCTCAACTCCCAC
ACGGATGTGGTGCCTGTCTTCAAGGAACATTGGAGTCACGACCCCTTTGAGGCCTTCAAG
GATTCTGAGGGCTACATCTATGCCAGGGGTGCCCAGGACATGAAGTGCGTCAGCATCCAG
TACCTGGAAGCTGTGAGGAGGCTGAAGGTGGAGGGCCACCGGTTCCCCAGAACCATCCAC
ATGACCTTTGTGCCTGATGAGGAGGTTGGGGGTCACCAAGGCATGGAGCTGTTCGTGCAG
CGGCCTGAGTTCCACGCCCTGAGGGCAGGCTTTGCCCTGGATGAGGGCATAGCCAATCCC
ACTGATGCCTTCACTGTCTTTTATAGTGAGCGGAGTCCCTGGTGGGTGCGGGTTACCAGC
ACTGGGAGGCCAGGCCATGCCTCACGCTTCATGGAGGACACAGCAGCAGAGAAGCTGCAC
AAGGTTGTAAACTCCATCCTGGCATTCCGGGAGAAGGAATGGCAGAGGCTGCAGTCAAAC
CCCCACCTGAAAGAGGGGTCCGTGACCTCCGTGAACCTGACTAAGCTAGAGGGTGGCGTG
GCCTATAACGTGATACCTGCCACCATGAGCGCCAGCTTTGACTTCCGTGTGGCACCGGAT
GTGGACTTCAAGGCTTTTGAGGAGCAGCTGCAGAGCTGGTGCCAGGCAGCTGGCGAGGGG
GTCACCCTAGAGTTTGCTCAGAAGTGGATGCACCCCCAAGTGACACCTACTGATGACTCA
AACCCTTGGTGGGCAGCTTTTAGCCGGGTCTGCAAGGATATGAACCTCACTCTGGAGCCT
GAGATCATGCCTGCTGCCACTGACAACCGCTATATCCGCGCGGTGGGGGTCCCAGCTCTA
GGCTTCTCACCCATGAACCGCACACCTGTGCTGCTGCACGACCACGATGAACGGCTGCAT
GAGGCTGTGTTCCTCCGTGGGGTGGACATATATACACGCCTGCTGCCTGCCCTTGCCAGT
GTGCCTGCCCTGCCCAGTGACAGCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 408 |
| Molecular Weight
| 45884.705 |
| Theoretical pI
| 6.174 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Aminoacylase-1
MTSKGPEEEHPSVTLFRQYLRIRTVQPKPDYGAAVAFFEETARQLGLGCQKVEVAPGYVV
TVLTWPGTNPTLSSILLNSHTDVVPVFKEHWSHDPFEAFKDSEGYIYARGAQDMKCVSIQ
YLEAVRRLKVEGHRFPRTIHMTFVPDEEVGGHQGMELFVQRPEFHALRAGFALDEGIANP
TDAFTVFYSERSPWWVRVTSTGRPGHASRFMEDTAAEKLHKVVNSILAFREKEWQRLQSN
PHLKEGSVTSVNLTKLEGGVAYNVIPATMSASFDFRVAPDVDFKAFEEQLQSWCQAAGEG
VTLEFAQKWMHPQVTPTDDSNPWWAAFSRVCKDMNLTLEPEIMPAATDNRYIRAVGVPAL
GFSPMNRTPVLLHDHDERLHEAVFLRGVDIYTRLLPALASVPALPSDS
|
| External Links |
|---|
| GenBank ID Protein
| 178071 |
| UniProtKB/Swiss-Prot ID
| Q03154 |
| UniProtKB/Swiss-Prot Entry Name
| ACY1_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| L07548 |
| GeneCard ID
| ACY1 |
| GenAtlas ID
| ACY1 |
| HGNC ID
| HGNC:177 |
| References |
|---|
| General References
| Not Available |