| Identification |
|---|
| HMDB Protein ID
| CDBP00517 |
| Secondary Accession Numbers
| Not Available |
| Name
| Dihydropteridine reductase |
| Description
| Not Available |
| Synonyms
|
- HDHPR
- Quinoid dihydropteridine reductase
|
| Gene Name
| QDPR |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in oxidoreductase activity |
| Specific Function
| The product of this enzyme, tetrahydrobiopterin (BH-4), is an essential cofactor for phenylalanine, tyrosine, and tryptophan hydroxylases.
|
| GO Classification
|
| Biological Process |
| cellular nitrogen compound metabolic process |
| cellular response to drug |
| response to glucagon stimulus |
| liver development |
| response to lead ion |
| response to aluminum ion |
| dihydrobiopterin metabolic process |
| tetrahydrobiopterin biosynthetic process |
| L-phenylalanine catabolic process |
| Cellular Component |
| cytosol |
| mitochondrion |
| Function |
| catalytic activity |
| oxidoreductase activity |
| Molecular Function |
| electron carrier activity |
| 6,7-dihydropteridine reductase activity |
| NADH binding |
| NADPH binding |
| Process |
| metabolic process |
|
| Cellular Location
|
Not Available
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Pterine Biosynthesis |    |  | | Folate biosynthesis | Not Available | | | Dopa-responsive dystonia |    | Not Available | | Hyperphenylalaniemia due to guanosine triphosphate cyclohydrolase deficiency |    | Not Available | | Hyperphenylalaninemia due to 6-pyruvoyltetrahydropterin synthase deficiency (ptps) |    | Not Available |
|
| Gene Properties |
|---|
| Chromosome Location
| 4 |
| Locus
| 4p15.31 |
| SNPs
| QDPR |
| Gene Sequence
|
>735 bp
ATGGCGGCGGCGGCGGCTGCAGGCGAGGCGCGCCGGGTGCTGGTGTACGGCGGCAGGGGC
GCTCTGGGTTCTCGATGCGTGCAGGCTTTTCGGGCCCGCAACTGGTGGGTTGCCAGCGTT
GATGTGGTGGAGAATGAAGAGGCCAGCGCTACGATCATTGTTAAAATGACAGACTCGTTC
ACTGAGCAGGCTGACCAGGTGACTGCTGAGGTTGGAAAGCTCTTGGGTGAAGAGAAGGTG
GATGCAATTCTTTGCGTTGCTGGAGGATGGGCCGGGGGCAATGCCAAATCCAAGTCTCTC
TTTAAGAACTGTGACCTGATGTGGAAGCAGAGCATATGGACATCGACCATCTCCAGCCAT
CTGGCTACCAAGCATCTCAAGGAAGGAGGCCTCCTGACCTTGGCTGGCGCAAAGGCTGCC
CTGGATGGGACTCCTGGTATGATCGGGTACGGCATGGCCAAGGGTGCTGTTCACCAGCTC
TGCCAGAGCCTGGCTGGGAAGAACAGCGGCATGCCGCCCGGGGCAGCCGCCATCGCTGTG
CTCCCGGTTACCCTGGATACCCCGATGAACAGGAAATCAATGCCTGAGGCTGACTTCAGC
TCCTGGACACCCTTAGAATTCCTAGTTGAAACTTTCCATGACTGGATCACAGGGAAAAAC
CGACCGAGCTCAGGAAGCCTAATCCAGGTGGTAACCACAGAAGGAAGGACGGAACTCACC
CCAGCATATTTTTAG
|
| Protein Properties |
|---|
| Number of Residues
| 244 |
| Molecular Weight
| 25789.295 |
| Theoretical pI
| 7.367 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Dihydropteridine reductase
MAAAAAAGEARRVLVYGGRGALGSRCVQAFRARNWWVASVDVVENEEASASIIVKMTDSF
TEQADQVTAEVGKLLGEEKVDAILCVAGGWAGGNAKSKSLFKNCDLMWKQSIWTSTISSH
LATKHLKEGGLLTLAGAKAALDGTPGMIGYGMAKGAVHQLCQSLAGKNSGMPPGAAAIAV
LPVTLDTPMNRKSMPEADFSSWTPLEFLVETFHDWITGKNRPSSGSLIQVVTTEGRTELT
PAYF
|
| External Links |
|---|
| GenBank ID Protein
| 30819 |
| UniProtKB/Swiss-Prot ID
| P09417 |
| UniProtKB/Swiss-Prot Entry Name
| DHPR_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| X04882 |
| GeneCard ID
| QDPR |
| GenAtlas ID
| QDPR |
| HGNC ID
| HGNC:9752 |
| References |
|---|
| General References
| Not Available |