| Identification |
|---|
| HMDB Protein ID
| CDBP00510 |
| Secondary Accession Numbers
| Not Available |
| Name
| Acyloxyacyl hydrolase |
| Description
| Not Available |
| Synonyms
|
- Acyloxyacyl hydrolase large subunit
- Acyloxyacyl hydrolase small subunit
|
| Gene Name
| AOAH |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in hydrolase activity |
| Specific Function
| Removes the secondary (acyloxyacyl-linked) fatty acyl chains from the lipid A region of bacterial lipopolysaccharides |
| GO Classification
|
| Function |
| hydrolase activity, acting on ester bonds |
| catalytic activity |
| hydrolase activity |
| Process |
| metabolic process |
| primary metabolic process |
| lipid metabolic process |
|
| Cellular Location
|
- Secreted
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:7 |
| Locus
| 7p14-p12 |
| SNPs
| AOAH |
| Gene Sequence
|
>1728 bp
ATGCAGTCCCCCTGGAAAATCCTTACGGTGGCGCCTCTATTCTTGCTCCTGTCTCTTCAG
TCCTCAGCCTCTCCAGCCAACGATGACCAGTCCAGGCCCAGCCTCTCGAATGGGCACACC
TGTGTAGGGTGTGTGCTGGTGGTGTCTGTAATAGAACAGCTTGCTCAAGTTCACAACTCG
ACGGTCCAGGCCTCGATGGAGAGACTGTGCAGCTACCTGCCTGAAAAACTGTTCTTGAAA
ACCACCTGCTATTTAGTCATTGACAAGTTTGGATCAGACATCATAAAACTGCTTAGCGCA
GATATGAATGCTGATGTGGTATGTCACACTCTGGAGTTTTGTAAACAGAACACTGGCCAA
CCATTGTGTCATCTCTACCCTCTTCCCAAGGAGACATGGAAATTTACACTACAGAAGGCA
AGACAAATTGTCAAGAAGTCCCCGATTCTGAAATATTCTAGAAGTGGTTCTGACATTTGT
TCACTCCCGGTTTTGGCCAAGATCTGCCAGAAAATTAAATTAGCTATGGAACAGTCTGTG
CCATTCAAAGATGTGGATTCAGACAAATACAGCGTTTTCCCAACACTGCGGGGCTATCAC
TGGCGGGGGAGAGACTGTAATGACAGCGACGAGTCAGTGTACCCAGGTAGAAGGCCGAAC
AACTGTGATGTCCATCAGGATTCAAACTGTAATGGCATTTGGGGTGTCGATCCAAAAGAT
GGAGTTCCATATGAGAAGAAATTCTGTGAAGGTTCACAGCCCAGGGGAATCATTTTGCTG
GGAGACTCAGCTGGGGCTCATTTTCACATCTCTCCTGAATGGATCACAGCGTCGCAGATG
TCTTTGAACTCTTTCATCAATCTACCAACAGCCCTTACCAACGAGCTTGACTGGCCCCAA
CTCTCTGGTGCTACAGGATTTCTGGACTCCACTGTTGGAATTAAAGAAAAATCTATTTAC
CTTCGCTTATGGAAAAGAAACCACTGTAATCACAGGGACTACCAGAATATTTCAAGAAAT
GGTGCATCTTCCCGAAACCTGAAGAAATTTATAGAAAGCTTGTCTAGAAACAAGGTGTTG
GACTATCCCGCCATCGTTATATATGCCATGATTGGAAATGATGTCTGCAGTGGGAAGAGT
GACCCAGTCCCAGCCATGACCACTCCTGAGAAACTCTACTCCAACGTCATGCAGACTCTG
AAGCATCTAAATTCCCACCTGCCCAATGGCAGCCATGTTATTTTGTATGGCTTACCAGAT
GGAACCTTTCTCTGGGATAATTTGCACAACAGATATCATCCTCTCGGCCAGCTAAATAAA
GACATGACCTATGCGCAGTTGTACTCCTTCCTGAACTGCCTCCAGGTCAGCCCCTGCCAC
GGCTGGATGTCTTCCAACAAGACGTTGCGGACTCTCACTTCAGAGAGAGCAGAGCAACTC
TCCAACACACTGAAAAAAATTGCAGCCAGTGAGAAATTTACAAACTTCAATCTTTTCTAC
ATGGATTTTGCCTTCCATGAAATCATACAGGAGTGGCAGAAGAGAGGCGGACAGCCCTGG
CAGCTCATCGAGCCCGTGGATGGATTCCACCCCAACGAGGTGGCTTTGCTGTTGTTGGCG
GATCATTTCTGGAAAAAGGTGCAGCTCCAGTGGCCCCAAATCCTGGGAAAGGAGAATCCG
TTCAACCCCCAGATTAAACAGGTGTTTGGAGACCAAGGCGGGCACTGA
|
| Protein Properties |
|---|
| Number of Residues
| 575 |
| Molecular Weight
| 65104.0 |
| Theoretical pI
| 8.24 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Acyloxyacyl hydrolase
MQSPWKILTVAPLFLLLSLQSSASPANDDQSRPSLSNGHTCVGCVLVVSVIEQLAQVHNS
TVQASMERLCSYLPEKLFLKTTCYLVIDKFGSDIIKLLSADMNADVVCHTLEFCKQNTGQ
PLCHLYPLPKETWKFTLQKARQIVKKSPILKYSRSGSDICSLPVLAKICQKIKLAMEQSV
PFKDVDSDKYSVFPTLRGYHWRGRDCNDSDESVYPGRRPNNWDVHQDSNCNGIWGVDPKD
GVPYEKKFCEGSQPRGIILLGDSAGAHFHISPEWITASQMSLNSFINLPTALTNELDWPQ
LSGATGFLDSTVGIKEKSIYLRLWKRNHCNHRDYQNISRNGASSRNLKKFIESLSRNKVL
DYPAIVIYAMIGNDVCSGKSDPVPAMTTPEKLYSNVMQTLKHLNSHLPNGSHVILYGLPD
GTFLWDNLHNRYHPLGQLNKDMTYAQLYSFLNCLQVSPCHGWMSSNKTLRTLTSERAEQL
SNTLKKIAASEKFTNFNLFYMDFAFHEIIQEWQKRGGQPWQLIEPVDGFHPNEVALLLLA
DHFWKKVQLQWPQILGKENPFNPQIKQVFGDQGGH
|
| External Links |
|---|
| GenBank ID Protein
| 62898684 |
| UniProtKB/Swiss-Prot ID
| P28039 |
| UniProtKB/Swiss-Prot Entry Name
| AOAH_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AK223476 |
| GeneCard ID
| AOAH |
| GenAtlas ID
| AOAH |
| HGNC ID
| HGNC:548 |
| References |
|---|
| General References
| Not Available |