Cannabis Compound Database: Showing Protein Platelet-activating factor acetylhydrolase 2, cytoplasmic (CDBP00507)

Identification Biological properties Gene properties Protein properties External links References XML Show 2 compounds

Identification

HMDB Protein ID

CDBP00507

Secondary Accession Numbers

Not Available

Name

Platelet-activating factor acetylhydrolase 2, cytoplasmic

Description

Not Available

Synonyms

SD-PLA2
Serine-dependent phospholipase A2
hSD-PLA2

Gene Name

PAFAH2

Protein Type

Enzyme

Biological Properties

General Function

Involved in 1-alkyl-2-acetylglycerophosphocholine esterase activity

Specific Function

Has a marked selectivity for phospholipids with short acyl chains at the sn-2 position. May share a common physiologic function with the plasma-type enzyme.

GO Classification

Biological Process
lipid catabolic process
lipid metabolic process
Cellular Component
cytoplasm
Component
protein complex
unlocalized protein complex
2-acetyl-1-alkylglycerophosphocholine esterase complex
Function
carboxylesterase activity
1-alkyl-2-acetylglycerophosphocholine esterase activity
hydrolase activity, acting on ester bonds
catalytic activity
hydrolase activity
carboxylic ester hydrolase activity
Molecular Function
phospholipid binding
1-alkyl-2-acetylglycerophosphocholine esterase activity
Process
metabolic process
lipid catabolism
primary metabolism
lipid metabolism
primary metabolic process
physiological process
metabolism
lipid metabolic process
lipid catabolic process

Cellular Location

Cytoplasmic
Cytoplasm

Pathways

Name	SMPDB/Pathwhiz	KEGG
Ether lipid metabolism	Not Available

Gene Properties

Chromosome Location

Locus

1p36

SNPs

PAFAH2

Gene Sequence

>1179 bp
ATGGGGGTCAACCAGTCTGTGGGCTTTCCACCTGTCACAGGACCCCACCTCGTAGGCTGT
GGGGATGTGATGGAGGGTCAGAATCTCCAGGGGAGCTTCTTTCGACTCTTCTACCCCTGC
CAAAAGGCAGAGGAGACCATGGAGCAGCCCCTGTGGATTCCCCGCTATGAGTACTGCACT
GGCCTGGCCGAGTACCTGCAGTTTAATAAGCGCTGCGGGGGCTTGCTGTTCAACCTGGCG
GTGGGATCTTGTCGCCTGCCTGTTAGCTGGAATGGCCCCTTTAAGACAAAGGACTCTGGA
TACCCCTTGATCATCTTCTCCCATGGCCTAGGAGCCTTCAGGACTTTGTATTCAGCCTTC
TGCATGGAGCTGGCCTCACGTGGCTTTGTGGTTGCTGTGCCAGAGCACAGGGACCGGTCA
GCGGCAACCACCTATTTCTGCAAGCAGGCCCCAGAAGAGAACCAGCCCACCAATGAATCG
CTGCAGGAGGAATGGATCCCTTTCCGTCGAGTTGAGGAAGGGGAGAAGGAATTTCATGTT
CGGAATCCCCAGGTGCATCAGCGGGTAAGCGAGTGTTTACGGGTGTTGAAGATCCTGCAA
GAGGTCACTGCTGGGCAGACTGTCTTCAACATCTTGCCTGGTGGCTTGGATCTGATGACT
TTGAAGGGCAACATTGACATGAGCCGTGTGGCTGTGATGGGACATTCATTTGGAGGGGCC
ACAGCTATTCTGGCTTTGGCCAAGGAGACCCAATTTCGGTGTGCGGTGGCTCTGGATGCT
TGGATGTTTCCTCTGGAACGTGACTTTTACCCCAAGGCCCGAGGACCTGTGTTCTTTATC
AATACTGAGAAATTCCAGACAATGGAGAGTGTCAATTTGATGAAGAAGATATGTGCCCAG
CATGAACAGTCTAGGATCATAACCGTTCTTGGTTCTGTTCATCGGAGTCAAACTGACTTT
GCTTTTGTGACTGGCAACTTGATTGGTAAATTCTTCTCCACTGAAACCCGTGGGAGCCTG
GACCCCTATGAAGGGCAGGAGGTTATGGTACGGGCCATGTTGGCCTTCCTGCAGAAGCAC
CTCGACCTGAAAGAAGACTATAATCAATGGAACAACCTTATTGAAGGCATTGGACCGTCG
CTCACCCCAGGGGCCCCCCACCATCTGTCCAGCCTGTAG

Protein Properties

Number of Residues

392

Molecular Weight

44035.255

Theoretical pI

6.887

Pfam Domain Function

PAF-AH_p_II (PF03403 )

Signals

Not Available

Transmembrane Regions

Not Available

Protein Sequence

>Platelet-activating factor acetylhydrolase 2, cytoplasmic
MGVNQSVGFPPVTGPHLVGCGDVMEGQNLQGSFFRLFYPCQKAEETMEQPLWIPRYEYCT
GLAEYLQFNKRCGGLLFNLAVGSCRLPVSWNGPFKTKDSGYPLIIFSHGLGAFRTLYSAF
CMELASRGFVVAVPEHRDRSAATTYFCKQAPEENQPTNESLQEEWIPFRRVEEGEKEFHV
RNPQVHQRVSECLRVLKILQEVTAGQTVFNILPGGLDLMTLKGNIDMSRVAVMGHSFGGA
TAILALAKETQFRCAVALDAWMFPLERDFYPKARGPVFFINTEKFQTMESVNLMKKICAQ
HEQSRIITVLGSVHRSQTDFAFVTGNLIGKFFSTETRGSLDPYEGQEVMVRAMLAFLQKH
LDLKEDYNQWNNLIEGIGPSLTPGAPHHLSSL

External Links

GenBank ID Protein

55859645

UniProtKB/Swiss-Prot ID

Q99487

UniProtKB/Swiss-Prot Entry Name

PAFA2_HUMAN

PDB IDs

Not Available

GenBank Gene ID

AL592064

GeneCard ID