| Identification |
|---|
| HMDB Protein ID
| CDBP00500 |
| Secondary Accession Numbers
| Not Available |
| Name
| Peptidyl-tRNA hydrolase 2, mitochondrial |
| Description
| Not Available |
| Synonyms
|
- Bcl-2 inhibitor of transcription 1
- PTH 2
|
| Gene Name
| PTRH2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in aminoacyl-tRNA hydrolase activity |
| Specific Function
| The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis (By similarity).
Promotes caspase-independent apoptosis by regulating the function of two transcriptional regulators, AES and TLE1.
|
| GO Classification
|
| Biological Process |
| apoptotic process |
| negative regulation of anoikis |
| positive regulation of anoikis |
| negative regulation of gene expression |
| Cellular Component |
| cytosol |
| mitochondrion |
| Function |
| catalytic activity |
| hydrolase activity |
| carboxylesterase activity |
| aminoacyl-trna hydrolase activity |
| hydrolase activity, acting on ester bonds |
| Molecular Function |
| aminoacyl-tRNA hydrolase activity |
| Process |
| macromolecule biosynthetic process |
| cellular macromolecule biosynthetic process |
| translation |
| metabolic process |
| biosynthetic process |
|
| Cellular Location
|
- Mitochondrion
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 17 |
| Locus
| 17q23.1 |
| SNPs
| PTRH2 |
| Gene Sequence
|
>540 bp
ATGCCCTCCAAATCCTTGGTTATGGAATATTTGGCTCATCCCAGTACACTCGGCTTGGCT
GTTGGAGTTGCTTGTGGCATGTGCCTGGGCTGGAGCCTTCGAGTATGCTTTGGGATGCTC
CCCAAAAGCAAGACGAGCAAGACACACACAGATACTGAAAGTGAAGCAAGCATCTTGGGA
GACAGCGGGGAGTACAAGATGATTCTTGTGGTTCGAAATGACTTAAAGATGGGAAAAGGG
AAAGTGGCTGCCCAGTGCTCTCATGCTGCTGTTTCAGCCTACAAGCAGATTCAAAGAAGA
AATCCTGAAATGCTCAAACAATGGGAATACTGTGGCCAGCCCAAGGTGGTGGTCAAAGCT
CCTGATGAAGAAACCCTGATTGCATTATTGGCCCATGCAAAAATGCTGGGACTGACTGTA
AGTTTAATTCAAGATGCTGGACGTACTCAGATTGCACCAGGCTCTCAAACTGTCCTAGGG
ATTGGGCCAGGACCAGCAGACCTAATTGACAAAGTCACTGGTCACCTAAAACTTTACTAG
|
| Protein Properties |
|---|
| Number of Residues
| 179 |
| Molecular Weight
| 19193.39 |
| Theoretical pI
| 8.733 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Peptidyl-tRNA hydrolase 2, mitochondrial
MPSKSLVMEYLAHPSTLGLAVGVACGMCLGWSLRVCFGMLPKSKTSKTHTDTESEASILG
DSGEYKMILVVRNDLKMGKGKVAAQCSHAAVSAYKQIQRRNPEMLKQWEYCGQPKVVVKA
PDEETLIALLAHAKMLGLTVSLIQDAGRTQIAPGSQTVLGIGPGPADLIDKVTGHLKLY
|
| External Links |
|---|
| GenBank ID Protein
| 4929763 |
| UniProtKB/Swiss-Prot ID
| Q9Y3E5 |
| UniProtKB/Swiss-Prot Entry Name
| PTH2_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| AF151905 |
| GeneCard ID
| PTRH2 |
| GenAtlas ID
| PTRH2 |
| HGNC ID
| HGNC:24265 |
| References |
|---|
| General References
| Not Available |