| Identification |
|---|
| HMDB Protein ID
| CDBP00497 |
| Secondary Accession Numbers
| Not Available |
| Name
| Platelet-activating factor acetylhydrolase |
| Description
| Not Available |
| Synonyms
|
- 1-alkyl-2-acetylglycerophosphocholine esterase
- 2-acetyl-1-alkylglycerophosphocholine esterase
- Group-VIIA phospholipase A2
- LDL-PLA(2)
- LDL-associated phospholipase A2
- PAF 2-acylhydrolase
- PAF acetylhydrolase
- gVIIA-PLA2
|
| Gene Name
| PLA2G7 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in 1-alkyl-2-acetylglycerophosphocholine esterase activity |
| Specific Function
| Modulates the action of platelet-activating factor (PAF) by hydrolyzing the sn-2 ester bond to yield the biologically inactive lyso-PAF. Has a specificity for substrates with a short residue at the sn-2 position. It is inactive against long-chain phospholipids.
|
| GO Classification
|
| Biological Process |
| positive regulation of inflammatory response |
| lipid catabolic process |
| low-density lipoprotein particle remodeling |
| lipid oxidation |
| plasma lipoprotein particle oxidation |
| positive regulation of monocyte chemotaxis |
| Cellular Component |
| low-density lipoprotein particle |
| Function |
| carboxylesterase activity |
| 1-alkyl-2-acetylglycerophosphocholine esterase activity |
| hydrolase activity, acting on ester bonds |
| catalytic activity |
| hydrolase activity |
| Molecular Function |
| phospholipid binding |
| calcium-independent phospholipase A2 activity |
| 1-alkyl-2-acetylglycerophosphocholine esterase activity |
| Process |
| metabolic process |
| primary metabolic process |
| lipid metabolic process |
| lipid catabolic process |
|
| Cellular Location
|
- Secreted
- extracellular space
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Ether lipid metabolism | Not Available |  |
|
| Gene Properties |
|---|
| Chromosome Location
| 6 |
| Locus
| 6p21.2-p12 |
| SNPs
| PLA2G7 |
| Gene Sequence
|
>1326 bp
ATGGTGCCACCCAAATTGCATGTGCTTTTCTGCCTCTGCGGCTGCCTGGCTGTGGTTTAT
CCTTTTGACTGGCAATACATAAATCCTGTTGCCCATATGAAATCATCAGCATGGGTCAAC
AAAATACAAGTACTGATGGCTGCTGCAAGCTTTGGCCAAACTAAAATCCCCCGGGGAAAT
GGGCCTTATTCCGTTGGTTGTACAGACTTAATGTTTGATCACACTAATAAGGGCACCTTC
TTGCGTTTATATTATCCATCCCAAGATAATGATCGCCTTGACACCCTTTGGATCCCAAAT
AAAGAATATTTTTGGGGTCTTAGCAAATTTCTTGGAACACACTGGCTTATGGGCAACATT
TTGAGGTTACTCTTTGGTTCAATGACAACTCCTGCAAACTGGAATTCCCCTCTGAGGCCT
GGTGAAAAATATCCACTTGTTGTTTTTTCTCATGGTCTTGGGGCATTCAGGACACTTTAT
TCTGCTATTGGCATTGACCTGGCATCTCATGGGTTTATAGTTGCTGCTGTAGAACACAGA
GATAGATCTGCATCTGCAACTTACTATTTCAAGGACCAATCTGCTGCAGAAATAGGGGAC
AAGTCTTGGCTCTACCTTAGAACCCTGAAACAAGAGGAGGAGACACATATACGAAATGAG
CAGGTACGGCAAAGAGCAAAAGAATGTTCCCAAGCTCTCAGTCTGATTCTTGACATTGAT
CATGGAAAGCCAGTGAAGAATGCATTAGATTTAAAGTTTGATATGGAACAACTGAAGGAC
TCTATTGATAGGGAAAAAATAGCAGTAATTGGACATTCTTTTGGTGGAGCAACGGTTATT
CAGACTCTTAGTGAAGATCAGAGATTCAGATGTGGTATTGCCCTGGATGCATGGATGTTT
CCACTGGGTGATGAAGTATATTCCAGAATTCCTCAGCCCCTCTTTTTTATCAACTCTGAA
TATTTCCAATATCCTGCTAATATCATAAAAATGAAAAAATGCTACTCACCTGATAAAGAA
AGAAAGATGATTACAATCAGGGGTTCAGTCCACCAGAATTTTGCTGACTTCACTTTTGCA
ACTGGCAAAATAATTGGACACATGCTCAAATTAAAGGGAGACATAGATTCAAATGTAGCT
ATTGATCTTAGCAACAAAGCTTCATTAGCATTCTTACAAAAGCATTTAGGACTTCATAAA
GATTTTGATCAGTGGGACTGCTTGATTGAAGGAGATGATGAGAATCTTATTCCAGGGACC
AACATTAACACAACCAATCAACACATCATGTTACAGAACTCTTCAGGAATAGAGAAATAC
AATTAG
|
| Protein Properties |
|---|
| Number of Residues
| 441 |
| Molecular Weight
| 50076.99 |
| Theoretical pI
| 7.556 |
| Pfam Domain Function
|
Not Available |
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Platelet-activating factor acetylhydrolase
MVPPKLHVLFCLCGCLAVVYPFDWQYINPVAHMKSSAWVNKIQVLMAAASFGQTKIPRGN
GPYSVGCTDLMFDHTNKGTFLRLYYPSQDNDRLDTLWIPNKEYFWGLSKFLGTHWLMGNI
LRLLFGSMTTPANWNSPLRPGEKYPLVVFSHGLGAFRTLYSAIGIDLASHGFIVAAVEHR
DRSASATYYFKDQSAAEIGDKSWLYLRTLKQEEETHIRNEQVRQRAKECSQALSLILDID
HGKPVKNALDLKFDMEQLKDSIDREKIAVIGHSFGGATVIQTLSEDQRFRCGIALDAWMF
PLGDEVYSRIPQPLFFINSEYFQYPANIIKMKKCYSPDKERKMITIRGSVHQNFADFTFA
TGKIIGHMLKLKGDIDSNVAIDLSNKASLAFLQKHLGLHKDFDQWDCLIEGDDENLIPGT
NINTTNQHIMLQNSSGIEKYN
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| Q13093 |
| UniProtKB/Swiss-Prot Entry Name
| PAFA_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| U20157 |
| GeneCard ID
| PLA2G7 |
| GenAtlas ID
| PLA2G7 |
| HGNC ID
| HGNC:9040 |
| References |
|---|
| General References
| Not Available |