| Identification |
|---|
| HMDB Protein ID
| CDBP00494 |
| Secondary Accession Numbers
| Not Available |
| Name
| Branched-chain-amino-acid aminotransferase, mitochondrial |
| Description
| Not Available |
| Synonyms
|
- BCAT(m)
- PP18
- Placental protein 18
|
| Gene Name
| BCAT2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in catalytic activity |
| Specific Function
| Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine. May also function as a transporter of branched chain alpha-keto acids.
|
| GO Classification
|
| Biological Process |
| leucine biosynthetic process |
| regulation of hormone levels |
| lactation |
| branched-chain amino acid catabolic process |
| cellular nitrogen compound metabolic process |
| valine metabolic process |
| branched-chain amino acid biosynthetic process |
| isoleucine catabolic process |
| Cellular Component |
| mitochondrial matrix |
| nucleus |
| Function |
| catalytic activity |
| branched-chain-amino-acid transaminase activity |
| transferase activity |
| transferase activity, transferring nitrogenous groups |
| transaminase activity |
| Molecular Function |
| branched-chain-amino-acid transaminase activity |
| L-isoleucine transaminase activity |
| L-leucine transaminase activity |
| L-valine transaminase activity |
| Process |
| cellular amino acid and derivative metabolic process |
| cellular amino acid metabolic process |
| branched chain family amino acid metabolic process |
| metabolic process |
| cellular metabolic process |
|
| Cellular Location
|
- Isoform B:Cytoplasm
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Valine, leucine and isoleucine biosynthesis | Not Available |  | | 2-Oxocarboxylic acid metabolism | Not Available |  |
|
| Gene Properties |
|---|
| Chromosome Location
| 19 |
| Locus
| 19q13 |
| SNPs
| BCAT2 |
| Gene Sequence
|
>1179 bp
ATGGCCGCAGCCGCTCTGGGGCAGATCTGGGCACGAAAGCTTCTCTCTGTCCCTTGGCTT
CTGTGTGGTCCCAGAAGATATGCCTCCTCCAGTTTCAAGGCTGCAGACCTGCAGCTGGAA
ATGACACAGAAGCCTCATAAGAAGCCTGGCCCCGGCGAGCCCCTGGTGTTTGGGAAGACA
TTTACCGACCACATGCTGATGGTGGAATGGAATGACAAGGGCTGGGGCCAGCCCCGAATC
CAGCCCTTCCAGAACCTCACGCTGCACCCAGCCTCCTCCAGCCTCCACTACTCCCTGCAG
CTGTTTGAGGGCATGAAGGCGTTCAAAGGCAAAGACCAGCAGGTGCGCCTCTTCCGCCCC
TGGCTCAACATGGACCGGATGCTGCGCTCAGCCATGCGCCTGTGCCTGCCGAGTTTCGAC
AAGCTGGAGTTGCTGGAGTGCATCCGCCGGCTCATCGAAGTGGACAAGGACTGGGTCCCC
GATGCCGCCGGCACCAGCCTCTATGTGCGGCCTGTGCTCATTGGGAACGAGCCCTCGCTG
GGTGTCAGCCAGCCCACGCGCGCGCTCCTGTTCGTCATTCTCTGCCCAGTGGGTGCCTAC
TTCCCTGGAGGCTCCGTGACCCCGGTCTCCCTCCTGGCCGACCCAGCCTTCATCCGGGCC
TGGGTGGGCGGGGTCGGCAACTACAAGTTAGGTGGGAATTATGGGCCCACCGTGTTAGTG
CAACAGGAGGCACTCAAGCGGGGCTGTGAACAGGTCCTCTGGCTGTATGGGCCCGACCAC
CAGCTCACCGAGGTGGGAACCATGAACATCTTTGTCTACTGGACCCACGAAGATGGGGTG
CTGGAGCTGGTGACGCCCCCGCTGAATGGTGTTATCCTGCCTGGAGTGGTCAGACAGAGT
CTACTGGACATGGCTCAGACCTGGGGTGAGTTCCGGGTGGTGGAGCGCACGATCACCATG
AAGCAGTTGCTGCGGGCCCTGGAGGAGGGCCGCGTGCGGGAAGTCTTTGGCTCGGGCACC
GCTTGCCAGGTCTGCCCAGTGCACCGAATCCTGTACAAAGACAGGAACCTCCACATTCCC
ACCATGGAAAATGGGCCTGAGCTGATCCTCCGCTTCCAGAAGGAGCTGAAGGAGATCCAG
TACGGAATCAGAGCCCACGAGTGGATGTTCCCGGTGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 392 |
| Molecular Weight
| 33776.315 |
| Theoretical pI
| 7.72 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Branched-chain-amino-acid aminotransferase, mitochondrial
MAAAALGQIWARKLLSVPWLLCGPRRYASSSFKAADLQLEMTQKPHKKPGPGEPLVFGKT
FTDHMLMVEWNDKGWGQPRIQPFQNLTLHPASSSLHYSLQLFEGMKAFKGKDQQVRLFRP
WLNMDRMLRSAMRLCLPSFDKLELLECIRRLIEVDKDWVPDAAGTSLYVRPVLIGNEPSL
GVSQPTRALLFVILCPVGAYFPGGSVTPVSLLADPAFIRAWVGGVGNYKLGGNYGPTVLV
QQEALKRGCEQVLWLYGPDHQLTEVGTMNIFVYWTHEDGVLELVTPPLNGVILPGVVRQS
LLDMAQTWGEFRVVERTITMKQLLRALEEGRVREVFGSGTACQVCPVHRILYKDRNLHIP
TMENGPELILRFQKELKEIQYGIRAHEWMFPV
|
| External Links |
|---|
| GenBank ID Protein
| 13699234 |
| UniProtKB/Swiss-Prot ID
| O15382 |
| UniProtKB/Swiss-Prot Entry Name
| BCAT2_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| AF268047 |
| GeneCard ID
| BCAT2 |
| GenAtlas ID
| BCAT2 |
| HGNC ID
| HGNC:977 |
| References |
|---|
| General References
| Not Available |