| Identification |
|---|
| HMDB Protein ID
| CDBP00490 |
| Secondary Accession Numbers
| Not Available |
| Name
| Alcohol dehydrogenase 4 |
| Description
| Not Available |
| Synonyms
|
- Alcohol dehydrogenase class II pi chain
|
| Gene Name
| ADH4 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in zinc ion binding |
| Specific Function
| Not Available |
| GO Classification
|
| Biological Process |
| alcohol catabolic process |
| cellular aldehyde metabolic process |
| quinone cofactor metabolic process |
| retinol metabolic process |
| xenobiotic metabolic process |
| ethanol oxidation |
| Cellular Component |
| cytosol |
| microtubule cytoskeleton |
| Function |
| binding |
| catalytic activity |
| transition metal ion binding |
| zinc ion binding |
| oxidoreductase activity |
| ion binding |
| cation binding |
| metal ion binding |
| Molecular Function |
| NAD binding |
| alcohol dehydrogenase activity, zinc-dependent |
| alditol:NADP+ 1-oxidoreductase activity |
| all-trans retinal binding |
| benzaldehyde dehydrogenase activity |
| NADPH:quinone reductase activity |
| retinol binding |
| retinol dehydrogenase activity |
| metal ion binding |
| zinc ion binding |
| Process |
| oxidation reduction |
| metabolic process |
|
| Cellular Location
|
- Cytoplasm
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Glycolysis / Gluconeogenesis | Not Available |  | | Metabolism of xenobiotics by cytochrome P450 | Not Available |  | | Drug metabolism - cytochrome P450 | Not Available |  | | Chemical carcinogenesis | Not Available |  |
|
| Gene Properties |
|---|
| Chromosome Location
| 4 |
| Locus
| 4q22 |
| SNPs
| ADH4 |
| Gene Sequence
|
>1143 bp
ATGGGCACCAAGGGCAAAGTTATTAAATGCAAAGCAGCCATCGCCTGGGAAGCAGGCAAG
CCCCTTTGCATTGAAGAGGTTGAAGTAGCTCCCCCCAAGGCTCATGAAGTTCGCATTCAG
ATCATTGCTACCTCCCTGTGCCATACTGATGCCACTGTTATCGATTCTAAATTTGAGGGC
CTAGCTTTCCCAGTGATCGTTGGCCATGAGGCTGCAGGTATTGTGGAAAGTATTGGGCCA
GGAGTGACCAACGTCAAACCAGGTGACAAAGTAATTCCACTTTATGCACCTCTATGTAGA
AAATGCAAGTTTTGTCTGAGTCCACTCACAAATTTGTGTGGGAAAATCAGTAATCTCAAA
AGTCCTGCTAGTGATCAACAACTAATGGAAGACAAAACCAGCAGGTTTACCTGCAAAGGA
AAACCAGTTTACCATTTCTTTGGAACCAGTACATTCTCTCAGTACACTGTGGTGTCAGAT
ATCAATCTTGCCAAAATAGATGATGATGCAAATTTAGAGAGAGTTTGTCTGCTTGGATGT
GGGTTTTCAACTGGCTATGGGGCTGCAATCAACAATGCCAAGGTCACCCCTGGTTCGACT
TGTGCTGTCTTTGGCCTAGGAGGTGTGGGTCTTTCTGCTGTAATGGGTTGTAAAGCAGCA
GGAGCTTCCAGAATCATAGGTATTGACATCAACAGTGAGAAGTTTGTGAAGGCTAAAGCC
CTGGGAGCCACTGACTGCCTCAATCCTAGAGACTTACATAAACCAATCCAGGAAGTTATC
ATTGAATTGACCAAGGGAGGTGTGGATTTTGCCCTTGACTGTGCAGGTGGATCTGAAACC
ATGAAAGCAGCCCTGGACTGTACAACCGCAGGCTGGGGATCATGTACTTTCATTGGAGTA
GCTGCTGGTAGCAAAGGATTGACTATTTTTCCAGAGGAGCTAATAATCGGCCGTACTATA
AATGGAACATTCTTTGGTGGTTGGAAAAGTGTAGATTCTATCCCAAAGCTGGTCACTGAC
TATAAGAATAAGAAATTCAATCTGGATGCATTGGTGACCCATACCCTGCCTTTTGACAAA
ATCAGTGAGGCATTTGACCTAATGAACCAAGGAAAAAGCGTCCGAACAATCCTCATCTTT
TGA
|
| Protein Properties |
|---|
| Number of Residues
| 380 |
| Molecular Weight
| 40221.335 |
| Theoretical pI
| 7.936 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Alcohol dehydrogenase 4
MGTKGKVIKCKAAIAWEAGKPLCIEEVEVAPPKAHEVRIQIIATSLCHTDATVIDSKFEG
LAFPVIVGHEAAGIVESIGPGVTNVKPGDKVIPLYAPLCRKCKFCLSPLTNLCGKISNLK
SPASDQQLMEDKTSRFTCKGKPVYHFFGTSTFSQYTVVSDINLAKIDDDANLERVCLLGC
GFSTGYGAAINNAKVTPGSTCAVFGLGGVGLSAVMGCKAAGASRIIGIDINSEKFVKAKA
LGATDCLNPRDLHKPIQEVIIELTKGGVDFALDCAGGSETMKAALDCTTAGWGSCTFIGV
AAGSKGLTIFPEELIIGRTINGTFFGGWKSVDSIPKLVTDYKNKKFNLDALVTHTLPFDK
ISEAFDLMNQGKSVRTILIF
|
| External Links |
|---|
| GenBank ID Protein
| 158255106 |
| UniProtKB/Swiss-Prot ID
| P08319 |
| UniProtKB/Swiss-Prot Entry Name
| ADH4_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| AK290835 |
| GeneCard ID
| ADH4 |
| GenAtlas ID
| ADH4 |
| HGNC ID
| HGNC:252 |
| References |
|---|
| General References
| Not Available |