| Identification |
|---|
| HMDB Protein ID
| CDBP00482 |
| Secondary Accession Numbers
| Not Available |
| Name
| S-formylglutathione hydrolase |
| Description
| Not Available |
| Synonyms
|
- Esterase D
- FGH
- Methylumbelliferyl-acetate deacetylase
|
| Gene Name
| ESD |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in carboxylesterase activity |
| Specific Function
| Serine hydrolase involved in the detoxification of formaldehyde.
|
| GO Classification
|
| Biological Process |
| formaldehyde catabolic process |
| Cellular Component |
| Golgi apparatus |
| nucleus |
| cytoplasmic membrane-bounded vesicle |
| Component |
| cytoplasmic vesicle |
| cytoplasmic membrane-bounded vesicle |
| organelle |
| vesicle |
| Function |
| hydrolase activity, acting on ester bonds |
| catalytic activity |
| hydrolase activity |
| carboxylesterase activity |
| thiolester hydrolase activity |
| s-formylglutathione hydrolase activity |
| Molecular Function |
| carboxylesterase activity |
| methylumbelliferyl-acetate deacetylase activity |
| S-formylglutathione hydrolase activity |
|
| Cellular Location
|
- Cytoplasm
- Cytoplasmic vesicle
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 13 |
| Locus
| 13q14.1-q14.2 |
| SNPs
| ESD |
| Gene Sequence
|
>849 bp
ATGGCATTGAAGCAGATTTCCAGCAACAAGTGCTTTGGGGGATTGCAGAAAGTTTTTGAA
CATGACAGTGTTGAACTAAACTGCAAAATGAAATTTGCTGTCTACTTACCACCAAAGGCA
GAAACAGGAAAGTGCCCTGCACTGTATTGGCTCTCAGGTTTAACTTGCACAGAGCAAAAT
TTTATATCAAAATCTGGTTATCATCAGTCTGCTTCAGAACATGGTCTTGTTGTCATTGCT
CCAGATACCAGCCCTCGTGGCTGCAATATTAAAGGTGAAGATGAGAGCTGGGACTTTGGC
ACTGGTGCTGGATTTTATGTTGATGCCACTGAAGATCCTTGGAAAACCAACTACAGAATG
TACTCTTATGTCACAGAGGAGCTTCCCCAACTCATAAATGCCAATTTTCCAGTGGATCCC
CAAAGGATGTCTATTTTTGGCCACTCCATGGGAGGTCATGGAGCTCTGATCTGTGCTTTG
AAAAATCCTGGAAAATACAAATCTGTGTCAGCATTTGCTCCAATTTGCAACCCTGTACTC
TGTCCCTGGGGCAAAAAAGCCTTTAGTGGATATTTGGGAACAGATCAAAGTAAATGGAAG
GCTTATGATGCTACCCACCTTGTGAAATCCTATCCAGGATCTCAGCTGGACATACTAATT
GATCAAGGGAAAGATGACCAGTTTCTTTTAGATGGACAGTTACTCCCTGATAACTTCATA
GCTGCCTGTACAGAAAAGAAAATCCCCGTTGTTTTTCGATTGCAAGAGGGTTATGATCAT
AGCTACTACTTCATTGCAACCTTTATTACTGACCACATCAGACATCATGCTAAATACCTG
AATGCATGA
|
| Protein Properties |
|---|
| Number of Residues
| 282 |
| Molecular Weight
| 31462.545 |
| Theoretical pI
| 7.014 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>S-formylglutathione hydrolase
MALKQISSNKCFGGLQKVFEHDSVELNCKMKFAVYLPPKAETGKCPALYWLSGLTCTEQN
FISKSGYHQSASEHGLVVIAPDTSPRGCNIKGEDESWDFGTGAGFYVDATEDPWKTNYRM
YSYVTEELPQLINANFPVDPQRMSIFGHSMGGHGALICALKNPGKYKSVSAFAPICNPVL
CPWGKKAFSGYLGTDQSKWKAYDATHLVKSYPGSQLDILIDQGKDDQFLLDGQLLPDNFI
AACTEKKIPVVFRLQEGYDHSYYFIATFITDHIRHHAKYLNA
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| P10768 |
| UniProtKB/Swiss-Prot Entry Name
| ESTD_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| AF112219 |
| GeneCard ID
| ESD |
| GenAtlas ID
| ESD |
| HGNC ID
| HGNC:3465 |
| References |
|---|
| General References
| Not Available |