Cannabis Compound Database: Showing Protein Hypoxanthine-guanine phosphoribosyltransferase (CDBP00458)

Identification Biological properties Gene properties Protein properties External links References XML Show 10 compounds

Identification

HMDB Protein ID

CDBP00458

Secondary Accession Numbers

Not Available

Name

Hypoxanthine-guanine phosphoribosyltransferase

Description

Not Available

Synonyms

HGPRT
HGPRTase

Gene Name

HPRT1

Protein Type

Enzyme

Biological Properties

General Function

Involved in hypoxanthine phosphoribosyltransferase activity

Specific Function

Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the 5-phosphoribosyl group from 5-phosphoribosylpyrophosphate onto the purine. Plays a central role in the generation of purine nucleotides through the purine salvage pathway.

GO Classification

Biological Process
GMP salvage
spermatogenesis
guanine salvage
purine ribonucleoside salvage
lymphocyte proliferation
response to amphetamine
striatum development
IMP salvage
dopamine metabolic process
dendrite morphogenesis
behavior
positive regulation of dopamine metabolic process
hypoxanthine salvage
protein homotetramerization
adenine salvage
grooming behavior
cytolysis
central nervous system neuron development
cerebral cortex neuron differentiation
GMP catabolic process
Cellular Component
cytosol
Component
cell part
intracellular part
cytoplasm
Function
catalytic activity
transferase activity
transferase activity, transferring pentosyl groups
transferase activity, transferring glycosyl groups
hypoxanthine phosphoribosyltransferase activity
Molecular Function
nucleotide binding
magnesium ion binding
guanine phosphoribosyltransferase activity
hypoxanthine phosphoribosyltransferase activity
Process
metabolic process
nitrogen compound metabolic process
cellular nitrogen compound metabolic process
nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
nucleobase, nucleoside and nucleotide metabolic process
nucleoside metabolic process
biosynthetic process
cellular biosynthetic process
heterocycle biosynthetic process
purine salvage
purine ribonucleoside salvage

Cellular Location

Cytoplasm

Pathways

Name	SMPDB/Pathwhiz	KEGG
IMP biosynthesis via salvage pathway	Not Available	Not Available
Drug metabolism - other enzymes	Not Available
Purine Metabolism
Adenosine Deaminase Deficiency		Not Available
Adenylosuccinate Lyase Deficiency		Not Available

Gene Properties

Chromosome Location

Locus

Xq26.1

SNPs

HPRT1

Gene Sequence

>657 bp
ATGGCGACCCGCAGCCCTGGCGTCGTGATTAGTGATGATGAACCAGGTTATGACCTTGAT
TTATTTTGCATACCTAATCATTATGCTGAGGATTTGGAAAGGGTGTTTATTCCTCATGGA
CTAATTATGGACAGGACTGAACGTCTTGCTCGAGATGTGATGAAGGAGATGGGAGGCCAT
CACATTGTAGCCCTCTGTGTGCTCAAGGGGGGCTATAAATTCTTTGCTGACCTGCTGGAT
TACATCAAAGCACTGAATAGAAATAGTGATAGATCCATTCCTATGACTGTAGATTTTATC
AGACTGAAGAGCTATTGTAATGACCAGTCAACAGGGGACATAAAAGTAATTGGTGGAGAT
GATCTCTCAACTTTAACTGGAAAGAATGTCTTGATTGTGGAAGATATAATTGACACTGGC
AAAACAATGCAGACTTTGCTTTCCTTGGTCAGGCAGTATAATCCAAAGATGGTCAAGGTC
GCAAGCTTGCTGGTGAAAAGGACCCCACGAAGTGTTGGATATAAGCCAGACTTTGTTGGA
TTTGAAATTCCAGACAAGTTTGTTGTAGGATATGCCCTTGACTATAATGAATACTTCAGG
GATTTGAATCATGTTTGTGTCATTAGTGAAACTGGAAAAGCAAAATACAAAGCCTAA

Protein Properties

Number of Residues

218

Molecular Weight

24579.155

Theoretical pI

6.689

Pfam Domain Function

Pribosyltran (PF00156 )

Signals

Not Available

Transmembrane Regions

Not Available

Protein Sequence

>Hypoxanthine-guanine phosphoribosyltransferase
MATRSPGVVISDDEPGYDLDLFCIPNHYAEDLERVFIPHGLIMDRTERLARDVMKEMGGH
HIVALCVLKGGYKFFADLLDYIKALNRNSDRSIPMTVDFIRLKSYCNDQSTGDIKVIGGD
DLSTLTGKNVLIVEDIIDTGKTMQTLLSLVRQYNPKMVKVASLLVKRTPRSVGYKPDFVG
FEIPDKFVVGYALDYNEYFRDLNHVCVISETGKAKYKA

External Links

GenBank ID Protein

306885

UniProtKB/Swiss-Prot ID

P00492

UniProtKB/Swiss-Prot Entry Name

HPRT_HUMAN

PDB IDs