| Identification |
|---|
| HMDB Protein ID
| CDBP00441 |
| Secondary Accession Numbers
| Not Available |
| Name
| Deoxyribonuclease-1 |
| Description
| Not Available |
| Synonyms
|
- DNase I
- Deoxyribonuclease I
- Dornase alfa
|
| Gene Name
| DNASE1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in deoxyribonuclease activity |
| Specific Function
| Among other functions, seems to be involved in cell death by apoptosis. Binds specifically to G-actin and blocks actin polymerization |
| GO Classification
|
| Function |
| hydrolase activity, acting on ester bonds |
| catalytic activity |
| hydrolase activity |
| nuclease activity |
| deoxyribonuclease activity |
| Process |
| metabolic process |
| macromolecule metabolic process |
| cellular macromolecule metabolic process |
| dna metabolic process |
| dna catabolic process |
|
| Cellular Location
|
- Secreted
- Nucleus envelope
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 16p13.3 |
| SNPs
| DNASE1 |
| Gene Sequence
|
>849 bp
ATGAGGGGCATGAAGCTGCTGGGGGCGCTGCTGGCACTGGCGGCCCTACTGCAGGGGGCC
GTGTCCCTGAAGATCGCAGCCTTCAACATCCAGACATTTGGGGAGACCAAGATGTCCAAT
GCCACCCTCGTCAGCTACATTGTGCAGATCCTGAGCCGCTATGACATCGCCCTGGTCCAG
GAGGTCAGAGACAGCCACCTGACTGCCGTGGGGAAGCTGCTGGACAACCTCAATCAGGAT
GCACCAGACACCTATCACTACGTGGTCAGTGAGCCACTGGGACGGAACAGCTATAAGGAG
CGCTACCTGTTCGTGTACAGGCCTGACCAGGTGTCTGCGGTGGACAGCTACTACTACGAT
GATGGCTGCGAGCCCTGCGGGAACGACACCTTCAACCGAGAGCCAGCCATTGTCAGGTTC
TTCTCCCGGTTCACAGAGGTCAGGGAGTTTGCCATTGTTCCCCTGCATGCGGCCCCGGGG
GACGCAGTAGCCGAGATCGACGCTCTCTATGACGTCTACCTGGATGTCCAAGAGAAATGG
GGCTTGGAGGACGTCATGTTGATGGGCGACTTCAATGCGGGCTGCAGCTATGTGAGACCC
TCCCAGTGGTCATCCATCCGCCTGTGGACAAGCCCCACCTTCCAGTGGCTGATCCCCGAC
AGCGCTGACACCACAGCTACACCCACGCACTGTGCCTATGACAGGATCGTGGTTGCAGGG
ATGCTGCTCCGAGGCGCCGTTGTTCCCGACTCGGCTCTTCCCTTTAACTTCCAGGCTGCC
TATGGCCTGAGTGACCAACTGGCCCAAGCCATCAGTGACCACTATCCAGTGGAGGTGATG
CTGAAGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 282 |
| Molecular Weight
| 31433.4 |
| Theoretical pI
| 4.49 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Deoxyribonuclease-1
MRGMKLLGALLALAALLQGAVSLKIAAFNIQTFGETKMSNATLVSYIVQILSRYDIALVQ
EVRDSHLTAVGKLLDNLNQDAPDTYHYVVSEPLGRNSYKERYLFVYRPDQVSAVDSYYYD
DGCEPCGNDTFNREPAIVRFFSRFTEVREFAIVPLHAAPGDAVAEIDALYDVYLDVQEKW
GLEDVMLMGDFNAGCSYVRPSQWSSIRLWTSPTFQWLIPDSADTTATPTHCAYDRIVVAG
MLLRGAVVPDSALPFNFQAAYGLSDQLAQAISDHYPVEVMLK
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| P24855 |
| UniProtKB/Swiss-Prot Entry Name
| DNAS1_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| M55983 |
| GeneCard ID
| DNASE1 |
| GenAtlas ID
| DNASE1 |
| HGNC ID
| HGNC:2956 |
| References |
|---|
| General References
| Not Available |