| Identification |
|---|
| HMDB Protein ID
| CDBP00429 |
| Secondary Accession Numbers
| Not Available |
| Name
| Adenine phosphoribosyltransferase |
| Description
| Not Available |
| Synonyms
|
- APRT
|
| Gene Name
| APRT |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in adenine phosphoribosyltransferase activity |
| Specific Function
| Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
|
| GO Classification
|
| Biological Process |
| lactation |
| purine nucleobase metabolic process |
| AMP salvage |
| purine ribonucleoside salvage |
| purine-containing compound salvage |
| adenine salvage |
| grooming behavior |
| Cellular Component |
| cytosol |
| nucleus |
| Component |
| cell part |
| intracellular part |
| cytoplasm |
| Function |
| catalytic activity |
| transferase activity |
| transferase activity, transferring pentosyl groups |
| transferase activity, transferring glycosyl groups |
| adenine phosphoribosyltransferase activity |
| Molecular Function |
| AMP binding |
| adenine binding |
| adenine phosphoribosyltransferase activity |
| Process |
| cellular nitrogen compound metabolic process |
| nucleobase, nucleoside, nucleotide and nucleic acid metabolic process |
| nucleobase, nucleoside and nucleotide metabolic process |
| cellular aromatic compound metabolic process |
| purine base metabolic process |
| purine base biosynthetic process |
| nucleoside metabolic process |
| cellular metabolic process |
| nucleobase metabolic process |
| purine base salvage |
| adenine salvage |
| metabolic process |
| nitrogen compound metabolic process |
|
| Cellular Location
|
- Cytoplasm
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Purine Metabolism |    |  | | AMP biosynthesis via salvage pathway | Not Available | Not Available | | Adenosine Deaminase Deficiency |    | Not Available | | Adenylosuccinate Lyase Deficiency |    | Not Available | | Gout or Kelley-Seegmiller Syndrome |    | Not Available |
|
| Gene Properties |
|---|
| Chromosome Location
| 16 |
| Locus
| 16q24 |
| SNPs
| APRT |
| Gene Sequence
|
>543 bp
ATGGCCGACTCCGAGCTGCAGCTGGTTGAGCAGCGGATCCGCAGCTTCCCCGACTTCCCC
ACCCCAGGCGTGGTATTCAGGGACATCTCGCCCGTCCTGAAGGACCCCGCCTCCTTCCGC
GCCGCCATCGGCCTCCTGGCGCGACACCTGAAGGCGACCCACGGGGGCCGCATCGACTAC
ATCGCAGGCCTAGACTCCCGAGGCTTCCTCTTTGGCCCCTCCCTGGCCCAGGAGCTTGGA
CTGGGCTGCGTGCTCATCCGAAAGCGGGGGAAGCTGCCAGGCCCCACTCTGTGGGCCTCC
TATTCCCTGGAGTACGGGAAGGCTGAGCTGGAGATTCAGAAAGACGCCCTGGAGCCAGGA
CAGAGGGTGGTCGTCGTGGATGATCTGCTGGCCACTGGTGGAACCATGAACGCTGCCTGT
GAGCTGCTGGGCCGCCTGCAGGCTGAGGTCCTGGAGTGCGTGAGCCTGGTGGAGCTGACC
TCGCTTAAGGGCAGGGAGAAGCTGGCACCTGTACCCTTCTTCTCTCTCCTGCAGTATGAG
TGA
|
| Protein Properties |
|---|
| Number of Residues
| 180 |
| Molecular Weight
| 19607.535 |
| Theoretical pI
| 6.019 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Adenine phosphoribosyltransferase
MADSELQLVEQRIRSFPDFPTPGVVFRDISPVLKDPASFRAAIGLLARHLKATHGGRIDY
IAGLDSRGFLFGPSLAQELGLGCVLIRKRGKLPGPTLWASYSLEYGKAELEIQKDALEPG
QRVVVVDDLLATGGTMNAACELLGRLQAEVLECVSLVELTSLKGREKLAPVPFFSLLQYE
|
| External Links |
|---|
| GenBank ID Protein
| 51476557 |
| UniProtKB/Swiss-Prot ID
| P07741 |
| UniProtKB/Swiss-Prot Entry Name
| APT_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| CR749423 |
| GeneCard ID
| APRT |
| GenAtlas ID
| APRT |
| HGNC ID
| HGNC:626 |
| References |
|---|
| General References
| Not Available |