| Identification |
|---|
| HMDB Protein ID
| CDBP00424 |
| Secondary Accession Numbers
| Not Available |
| Name
| Alpha-N-acetylgalactosaminidase |
| Description
| Not Available |
| Synonyms
|
- Alpha-galactosidase B
|
| Gene Name
| NAGA |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in catalytic activity |
| Specific Function
| Removes terminal alpha-N-acetylgalactosamine residues from glycolipids and glycopeptides. Required for the breakdown of glycolipids.
|
| GO Classification
|
| Biological Process |
| glycosylceramide catabolic process |
| oligosaccharide metabolic process |
| carbohydrate catabolic process |
| glycoside catabolic process |
| Cellular Component |
| cytoplasm |
| lysosome |
| Function |
| ion binding |
| cation binding |
| binding |
| catalytic activity |
| hydrolase activity |
| hydrolase activity, acting on glycosyl bonds |
| hydrolase activity, hydrolyzing o-glycosyl compounds |
| Molecular Function |
| alpha-N-acetylgalactosaminidase activity |
| alpha-galactosidase activity |
| cation binding |
| Process |
| primary metabolic process |
| carbohydrate metabolic process |
| metabolic process |
|
| Cellular Location
|
- Lysosome
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Glycosphingolipid biosynthesis - globo series | Not Available |  | | Lysosome | Not Available |  |
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| NAGA |
| Gene Sequence
|
>1236 bp
ATGCTGCTGAAGACAGTGCTCTTGCTGGGACATGTGGCCCAGGTGCTGATGCTGGACAAT
GGGCTCCTGCAGACACCACCCATGGGCTGGCTGGCCTGGGAACGCTTCCGCTGCAACATT
AACTGTGATGAGGACCCAAAGAACTGCATAAGTGAACAGCTCTTCATGGAGATGGCTGAC
CGGATGGCACAGGATGGATGGCGGGACATGGGCTACACATACCTAAACATTGATGACTGC
TGGATCGGCGGTCGCGATGCCAGTGGCCGCCTGATGCCAGATCCCAAGCGCTTCCCTCAT
GGCATTCCTTTCCTGGCTGACTACGTTCACTCCCTGGGCCTGAAGTTGGGTATCTACGCG
GACATGGGCAACTTCACCTGCATGGGTTACCCAGGCACCACACTGGACAAGGTGGTCCAG
GATGCTCAGACCTTCGCCGAGTGGAAGGTAGACATGCTCAAGCTGGATGGCTGCTTCTCC
ACCCCCGAGGAGCGGGCCCAGGGGTACCCCAAGATGGCTGCTGCCCTGAATGCCACAGGC
CGCCCCATCGCCTTCTCCTGCAGCTGGCCAGCCTATGAAGGCGGCCTCCCCCCAAGGGTG
AACTACAGTCTGCTGGCGGACATCTGCAACCTCTGGCGTAACTATGATGACATCCAGGAC
TCCTGGTGGAGCGTGCTCTCCATCCTGAATTGGTTCGTGGAGCACCAGGACATACTGCAG
CCAGTGGCCGGCCCTGGGCACTGGAATGACCCTGACATGCTGCTCATTGGGAACTTTGGT
CTCAGCTTAGAGCAATCCCGGGCCCAGATGGCCCTGTGGACGGTGCTGGCAGCCCCCCTC
TTGATGTCCACAGACCTGCGTACCATCTCCGCCCAGAACATGGACATTCTGCAGAATCCA
CTCATGATCAAAATCAACCAGGATCCCTTAGGCATCCAGGGACGCAGGATTCACAAGGAA
AAATCTCTCATCGAAGTGTACATGCGGCCTCTGTCCAACAAGGCTAGCGCCTTAGTCTTC
TTCAGCTGCAGGACCGATATGCCTTATCGCTACCACTCCTCCCTTGGCCAGCTGAACTTC
ACCGGGTCTGTGATATATGAGGCCCAGGACGTCTACTCAGGTGACATCATCAGTGGCCTC
CGAGATGAAACCAACTTCACAGTGATCATCAACCCTTCAGGGGTAGTGATGTGGTACCTG
TATCCCATCAAGAACCTGGAGATGTCCCAGCAGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 411 |
| Molecular Weight
| Not Available |
| Theoretical pI
| Not Available |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Alpha-N-acetylgalactosaminidase
MLLKTVLLLGHVAQVLMLDNGLLQTPPMGWLAWERFRCNINCDEDPKNCISEQLFMEMAD
RMAQDGWRDMGYTYLNIDDCWIGGRDASGRLMPDPKRFPHGIPFLADYVHSLGLKLGIYA
DMGNFTCMGYPGTTLDKVVQDAQTFAEWKVDMLKLDGCFSTPEERAQGYPKMAAALNATG
RPIAFSCSWPAYEGGLPPRVNYSLLADICNLWRNYDDIQDSWWSVLSILNWFVEHQDILQ
PVAGPGHWNDPDMLLIGNFGLSLEQSRAQMALWTVLAAPLLMSTDLRTISAQNMDILQNP
LMIKINQDPLGIQGRRIHKEKSLIEVYMRPLSNKASALVFFSCRTDMPYRYHSSLGQLNF
TGSVIYEAQDVYSGDIISGLRDETNFTVIINPSGVVMWYLYPIKNLEMSQQ
|
| External Links |
|---|
| GenBank ID Protein
| 178248 |
| UniProtKB/Swiss-Prot ID
| P17050 |
| UniProtKB/Swiss-Prot Entry Name
| NAGAB_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| M62783 |
| GeneCard ID
| NAGA |
| GenAtlas ID
| NAGA |
| HGNC ID
| HGNC:7631 |
| References |
|---|
| General References
| Not Available |