| Identification |
|---|
| HMDB Protein ID
| CDBP00419 |
| Secondary Accession Numbers
| Not Available |
| Name
| Thiopurine S-methyltransferase |
| Description
| Not Available |
| Synonyms
|
- Thiopurine methyltransferase
|
| Gene Name
| TPMT |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in thiopurine S-methyltransferase activity |
| Specific Function
| Catalyzes the S-methylation of thiopurine drugs such as 6-mercaptopurine.
|
| GO Classification
|
| Biological Process |
| small molecule metabolic process |
| xenobiotic metabolic process |
| nucleobase-containing compound metabolic process |
| Cellular Component |
| cytosol |
| Component |
| cell part |
| intracellular part |
| cytoplasm |
| Function |
| catalytic activity |
| transferase activity |
| s-methyltransferase activity |
| thiopurine s-methyltransferase activity |
| transferase activity, transferring one-carbon groups |
| methyltransferase activity |
| Molecular Function |
| thiopurine S-methyltransferase activity |
| Process |
| metabolic process |
|
| Cellular Location
|
- Cytoplasm
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Drug metabolism - other enzymes | Not Available |  | | Mercaptopurine Action Pathway |    | Not Available | | Mercaptopurine Metabolism Pathway |    | Not Available | | Thioguanine Action Pathway |    | Not Available | | Azathioprine Action Pathway |    | Not Available |
|
| Gene Properties |
|---|
| Chromosome Location
| 6 |
| Locus
| 6p22.3 |
| SNPs
| TPMT |
| Gene Sequence
|
>738 bp
ATGGATGGTACAAGAACTTCACTTGACATTGAAGAGTACTCGGATACTGAGGTACAGAAA
AACCAAGTACTAACTCTGGAAGAATGGCAAGACAAGTGGGTGAACGGCAAGACTGCTTTT
CATCAGGAACAAGGACATCAGCTATTAAAGAAGCATTTAGATACTTTCCTTAAAGGCAAG
AGTGGACTGAGGGTATTTTTTCCTCTTTGCGGAAAAGCGGTTGAGATGAAATGGTTTGCA
GACCGGGGACACAGTGTAGTTGGTGTGGAAATCAGTGAACTTGGGATACAAGAATTTTTT
ACAGAGCAGAATCTTTCTTACTCAGAAGAACCAATCACCGAAATTCCTGGAACCAAAGTA
TTTAAGAGTTCTTCGGGGAACATTTCATTGTACTGTTGCAGTATTTTTGATCTTCCCAGG
ACAAATATTGGCAAATTTGACATGATTTGGGATAGAGGAGCATTAGTTGCCATTAATCCA
GGTGATCGCAAATGCTATGCAGATACAATGTTTTCCCTCCTGGGAAAGAAGTTTCAGTAT
CTCCTGTGTGTTCTTTCTTATGATCCAACTAAACATCCAGGTCCACCATTTTATGTTCCA
CATGCTGAAATTGAAAGGTTGTTTGGTAAAATATGCAATATACGTTGTCTTGAGAAGGTT
GATGCTTTTGAAGAACGACATAAAAGTTGGGGAATTGACTGTCTTTTTGAAAAGTTATAT
CTACTTACAGAAAAGTAA
|
| Protein Properties |
|---|
| Number of Residues
| 245 |
| Molecular Weight
| 28180.09 |
| Theoretical pI
| 6.23 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Thiopurine S-methyltransferase
MDGTRTSLDIEEYSDTEVQKNQVLTLEEWQDKWVNGKTAFHQEQGHQLLKKHLDTFLKGK
SGLRVFFPLCGKAVEMKWFADRGHSVVGVEISELGIQEFFTEQNLSYSEEPITEIPGTKV
FKSSSGNISLYCCSIFDLPRTNIGKFDMIWDRGALVAINPGDRKCYADTMFSLLGKKFQY
LLCVLSYDPTKHPGPPFYVPHAEIERLFGKICNIRCLEKVDAFEERHKSWGIDCLFEKLY
LLTEK
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| P51580 |
| UniProtKB/Swiss-Prot Entry Name
| TPMT_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| S62904 |
| GeneCard ID
| TPMT |
| GenAtlas ID
| TPMT |
| HGNC ID
| HGNC:12014 |
| References |
|---|
| General References
| Not Available |