Cannabis Compound Database: Showing Protein S-adenosylmethionine synthase isoform type-1 (CDBP00409)

Identification Biological properties Gene properties Protein properties External links References XML Show 9 compounds

Identification

HMDB Protein ID

CDBP00409

Secondary Accession Numbers

Not Available

Name

S-adenosylmethionine synthase isoform type-1

Description

Not Available

Synonyms

AdoMet synthase 1
MAT 1
MAT-I/III
Methionine adenosyltransferase 1
Methionine adenosyltransferase I/III

Gene Name

MAT1A

Protein Type

Enzyme

Biological Properties

General Function

Involved in methionine adenosyltransferase activity

Specific Function

Catalyzes the formation of S-adenosylmethionine from methionine and ATP.

GO Classification

Biological Process
cellular nitrogen compound metabolic process
sulfur amino acid metabolic process
xenobiotic metabolic process
S-adenosylmethionine biosynthetic process
methanogenesis
methylation
one-carbon metabolic process
Cellular Component
cytosol
Function
methionine adenosyltransferase activity
transferase activity, transferring alkyl or aryl (other than methyl) groups
binding
catalytic activity
transferase activity
nucleoside binding
purine nucleoside binding
adenyl nucleotide binding
adenyl ribonucleotide binding
atp binding
Molecular Function
metal ion binding
ATP binding
methionine adenosyltransferase activity
Process
metabolic process
cellular metabolic process
one-carbon metabolic process

Cellular Location

Not Available

Pathways

Name	SMPDB/Pathwhiz	KEGG
S-adenosyl-L-methionine biosynthesis	Not Available	Not Available
Cysteine and methionine metabolism	Not Available

Gene Properties

Chromosome Location

Locus

10q22

SNPs

MAT1A

Gene Sequence

>1188 bp
ATGAATGGACCGGTGGATGGCTTGTGTGACCACTCTCTAAGTGAAGGAGTCTTCATGTTC
ACATCGGAGTCTGTGGGAGAGGGACACCCGGATAAGATCTGTGACCAGATCAGTGATGCA
GTGCTGGATGCCCATCTCAAGCAAGACCCCAATGCCAAGGTGGCCTGTGAGACAGTGTGC
AAGACCGGCATGGTGCTGCTGTGTGGTGAGATCACCTCAATGGCCATGGTGGACTACCAG
CGGGTGGTGAGGGACACCATCAAGCACATCGGCTACGATGACTCAGCCAAGGGCTTTGAC
TTCAAGACTTGCAACGTGCTGGTGGCTTTGGAGCAGCAATCCCCAGATATTGCCCAGTGC
GTCCATCTGGACAGAAATGAGGAGGATGTGGGGGCAGGAGATCAGGGTTTGATGTTCGGC
TATGCTACCGACGAGACAGAGGAGTGCATGCCCCTCACCATCATCCTTGCTCACAAGCTC
AACGCCCGGATGGCAGACCTCAGGCGCTCCGGCCTCCTCCCCTGGCTGCGGCCTGACTCT
AAGACTCAGGTGACAGTTCAGTACATGCAGGACAATGGCGCAGTCATCCCTGTGCGCATC
CACACCATCGTCATCTCTGTGCAGCACAACGAAGACATCACGCTGGAGGAGATGCGCAGG
GCCCTGAAGGAGCAAGTCATCAGGGCCGTGGTGCCGGCCAAGTACCTGGACGAAGACACC
GTCTACCACCTGCAGCCCAGTGGGCGGTTTGTCATCGGAGGTCCCCAGGGGGATGCGGGT
GTCACTGGCCGTAAGATTATTGTGGACACCTATGGCGGCTGGGGGGCTCATGGTGGTGGG
GCCTTCTCTGGGAAGGACTACACCAAGGTAGACCGCTCAGCTGCATATGCTGCCCGCTGG
GTGGCCAAGTCTCTGGTGAAAGCAGGGCTCTGCCGGAGAGTGCTTGTCCAGGTTTCCTAT
GCCATTGGTGTGGCCGAGCCGCTGTCCATTTCCATCTTCACCTACGGAACCTCTCAGAAG
ACAGAGCGAGAGCTGCTGGATGTGGTGCATAAGAACTTCGACCTCCGGCCGGGCGTCATT
GTCAGGGATTTGGACTTGAAGAAGCCCATCTACCAGAAGACAGCATGCTACGGCCATTTC
GGAAGAAGCGAGTTCCCATGGGAGGTTCCCAGGAAGCTTGTATTTTAG

Protein Properties

Number of Residues

395

Molecular Weight

43647.6

Theoretical pI

6.29

Pfam Domain Function

S-AdoMet_synt_C (PF02773 )
S-AdoMet_synt_M (PF02772 )
S-AdoMet_synt_N (PF00438 )

Signals

Not Available

Transmembrane Regions

Not Available

Protein Sequence

>S-adenosylmethionine synthase isoform type-1
MNGPVDGLCDHSLSEGVFMFTSESVGEGHPDKICDQISDAVLDAHLKQDPNAKVACETVC
KTGMVLLCGEITSMAMVDYQRVVRDTIKHIGYDDSAKGFDFKTCNVLVALEQQSPDIAQC
VHLDRNEEDVGAGDQGLMFGYATDETEECMPLTIILAHKLNARMADLRRSGLLPWLRPDS
KTQVTVQYMQDNGAVIPVRIHTIVISVQHNEDITLEEMRRALKEQVIRAVVPAKYLDEDT
VYHLQPSGRFVIGGPQGDAGVTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARW
VAKSLVKAGLCRRVLVQVSYAIGVAEPLSISIFTYGTSQKTERELLDVVHKNFDLRPGVI
VRDLDLKKPIYQKTACYGHFGRSEFPWEVPRKLVF

External Links

GenBank ID Protein

55959182

UniProtKB/Swiss-Prot ID

Q00266

UniProtKB/Swiss-Prot Entry Name

METK1_HUMAN

PDB IDs