| Identification |
|---|
| HMDB Protein ID
| CDBP00404 |
| Secondary Accession Numbers
| Not Available |
| Name
| Protein-L-isoaspartate(D-aspartate) O-methyltransferase |
| Description
| Not Available |
| Synonyms
|
- L-isoaspartyl protein carboxyl methyltransferase
- PIMT
- Protein L-isoaspartyl/D-aspartyl methyltransferase
- Protein-beta-aspartate methyltransferase
|
| Gene Name
| PCMT1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in protein-L-isoaspartate (D-aspartate) O-methyltransferase activity |
| Specific Function
| Catalyzes the methyl esterification of L-isoaspartyl and D-aspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins. Acts on microtubule-associated protein 2, calreticulin, clathrin light chains a and b, Ubiquitin carboxyl-terminal hydrolase isozyme L1, phosphatidylethanolamine-binding protein 1, stathmin, beta-synuclein and alpha-synuclein (By similarity).
|
| GO Classification
|
| Biological Process |
| protein repair |
| S-adenosylhomocysteine metabolic process |
| S-adenosylmethionine metabolic process |
| Cellular Component |
| endoplasmic reticulum |
| Function |
| protein-l-isoaspartate (d-aspartate) o-methyltransferase activity |
| transferase activity, transferring one-carbon groups |
| methyltransferase activity |
| catalytic activity |
| transferase activity |
| s-adenosylmethionine-dependent methyltransferase activity |
| Molecular Function |
| protein-L-isoaspartate (D-aspartate) O-methyltransferase activity |
| Process |
| metabolic process |
| macromolecule metabolic process |
| macromolecule modification |
| protein modification process |
|
| Cellular Location
|
- Cytoplasm
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 6 |
| Locus
| 6q24-q25 |
| SNPs
| PCMT1 |
| Gene Sequence
|
>684 bp
ATGGCCTGGAAATCCGGCGGCGCCAGCCACTCGGAGCTAATCCACAATCTCCGCAAAAAT
GGAATCATCAAGACAGATAAAGTATTTGAAGTGATGCTGGCTACAGACCGCTCCCACTAT
GCAAAATGTAACCCATACATGGATTCTCCACAATCAATAGGTTTCCAAGCAACAATCAGT
GCTCCACACATGCATGCATATGCGCTAGAACTTCTATTTGATCAGTTGCATGAAGGAGCT
AAAGCTCTTGATGTAGGATCTGGAAGTGGAATCCTTACTGCATGTTTTGCACGTATGGTT
GGATGTACTGGAAAAGTCATAGGAATTGATCACATTAAAGAGCTAGTAGATGACTCAGTA
AATAATGTCAGGAAGGACGATCCAACACTTCTGTCTTCAGGGAGAGTACAGCTTGTTGTG
GGGGATGGAAGAATGGGATATGCTGAAGAAGCCCCTTATGATGCCATTCATGTGGGAGCT
GCAGCCCCTGTTGTACCCCAGGCGCTAATAGATCAGTTAAAGCCCGGAGGAAGATTGATA
TTGCCTGTTGGTCCTGCAGGCGGAAACCAAATGTTGGAGCAGTATGACAAGCTACAAGAT
GGCAGCATCAAAATGAAGCCTCTGATGGGGGTGATATACGTGCCTTTAACAGATAAAGAA
AAGCAGTGGTCCAGGTGGAAGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 227 |
| Molecular Weight
| 30357.695 |
| Theoretical pI
| 6.725 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Protein-L-isoaspartate(D-aspartate) O-methyltransferase
MAWKSGGASHSELIHNLRKNGIIKTDKVFEVMLATDRSHYAKCNPYMDSPQSIGFQATIS
APHMHAYALELLFDQLHEGAKALDVGSGSGILTACFARMVGCTGKVIGIDHIKELVDDSI
NNVRKDDPTLLSSGRVQLVVGDGRMGYAEEAPYDAIHVGAAAPVVPQALIDQLKPGGRLI
LPVGPAGGNQMLEQYDKLQDGSIKMKPLMGVIYVPLTDKEKQWSRWK
|
| External Links |
|---|
| GenBank ID Protein
| 158260471 |
| UniProtKB/Swiss-Prot ID
| P22061 |
| UniProtKB/Swiss-Prot Entry Name
| PIMT_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| AK289724 |
| GeneCard ID
| PCMT1 |
| GenAtlas ID
| PCMT1 |
| HGNC ID
| HGNC:8728 |
| References |
|---|
| General References
| Not Available |