Showing Protein Diphthine synthase (CDBP00399)
| Identification | |||||||||||||||||||||
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| HMDB Protein ID | CDBP00399 | ||||||||||||||||||||
| Secondary Accession Numbers | Not Available | ||||||||||||||||||||
| Name | Diphthine synthase | ||||||||||||||||||||
| Description | Not Available | ||||||||||||||||||||
| Synonyms |
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| Gene Name | DPH5 | ||||||||||||||||||||
| Protein Type | Enzyme | ||||||||||||||||||||
| Biological Properties | |||||||||||||||||||||
| General Function | Involved in methyltransferase activity | ||||||||||||||||||||
| Specific Function | S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis (By similarity). | ||||||||||||||||||||
| GO Classification |
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| Cellular Location | Not Available | ||||||||||||||||||||
| Pathways |
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| Gene Properties | |||||||||||||||||||||
| Chromosome Location | 1 | ||||||||||||||||||||
| Locus | 1p21.2 | ||||||||||||||||||||
| SNPs | DPH5 | ||||||||||||||||||||
| Gene Sequence |
>858 bp ATGCTTTATCTCATCGGGTTGGGCCTGGGAGATGCCAAGGACATCACAGTCAAGGGCCTG GAAGTTGTTAGACGCTGCAGTCGAGTGTATCTGGAAGCCTACACCTCAGTCCTAACTGTA GGGAAGGAAGCCTTGGAAGAGTTTTATGGAAGAAAATTGGTTGTTGCTGATAGAGAAGAA GTGGAACAAGAAGCAGATAATATTTTAAAGGATGCTGATATCAGTGATGTTGCATTCCTT GTGGTTGGTGATCCATTTGGGGCCACAACACACAGTGATCTTGTTCTAAGAGCAACAAAG CTGGGAATTCCTTATAGAGTTATTCACAATGCCTCCATAATGAATGCTGTAGGCTGCTGT GGTTTACAGTTATATAAGTTTGGAGAGACAGTTTCTATTGTTTTTTGGACAGACACTTGG AGACCAGAAAGCTTCTTTGACAAAGTGAAGAAGAACAGACAAAATGGCATGCACACATTA TGTTTACTAGACATCAAAGTAAAGGAGCAGTCTTTGGAAAATCTAATCAAGGGAAGGAAG ATCTATGAACCTCCACGGTATATGAGTGTAAACCAAGCAGCCCAGCAGCTTCTGGAGATT GTTCAAAATCAAAGAATACGAGGAGAAGAACCAGCAGTTACCGAGGAGACACTTTGTGTT GGCTTAGCCAGGGTTGGAGCCGACGACCAGAAAATTGCAGCAGGCACTTTAAGGCAAATG TGCACTGTGGACTTGGGAGAACCATTGCATTCCTTGATCATCACAGGAGGCAGCATACAT CCAATGGAGATGGAGATGCTAAGTCTGTTTTCCATACCAGAAAATAGCTCAGAATCTCAA AGCATCAATGGACTTTGA |
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| Protein Properties | |||||||||||||||||||||
| Number of Residues | 285 | ||||||||||||||||||||
| Molecular Weight | 31651.17 | ||||||||||||||||||||
| Theoretical pI | 5.307 | ||||||||||||||||||||
| Pfam Domain Function |
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| Signals | Not Available | ||||||||||||||||||||
| Transmembrane Regions | Not Available | ||||||||||||||||||||
| Protein Sequence |
>Diphthine synthase MLYLIGLGLGDAKDITVKGLEVVRRCSRVYLEAYTSVLTVGKEALEEFYGRKLVVADREE VEQEADNILKDADISDVAFLVVGDPFGATTHSDLVLRATKLGIPYRVIHNASIMNAVGCC GLQLYKFGETVSIVFWTDTWRPESFFDKVKKNRQNGMHTLCLLDIKVKEQSLENLIKGRK IYEPPRYMSVNQAAQQLLEIVQNQRIRGEEPAVTEETLCVGLARVGADDQKIAAGTLRQM CTVDLGEPLHSLIITGGSIHPMEMEMLSLFSIPENSSESQSINGL |
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| External Links | |||||||||||||||||||||
| GenBank ID Protein | 117190326 | ||||||||||||||||||||
| UniProtKB/Swiss-Prot ID | Q9H2P9 | ||||||||||||||||||||
| UniProtKB/Swiss-Prot Entry Name | DPH5_HUMAN | ||||||||||||||||||||
| PDB IDs | Not Available | ||||||||||||||||||||
| GenBank Gene ID | NM_001077394.1 | ||||||||||||||||||||
| GeneCard ID | DPH5 | ||||||||||||||||||||
| GenAtlas ID | DPH5 | ||||||||||||||||||||
| HGNC ID | HGNC:24270 | ||||||||||||||||||||
| References | |||||||||||||||||||||
| General References | Not Available | ||||||||||||||||||||