| Identification |
|---|
| HMDB Protein ID
| CDBP00399 |
| Secondary Accession Numbers
| Not Available |
| Name
| Diphthine synthase |
| Description
| Not Available |
| Synonyms
|
- Diphthamide biosynthesis methyltransferase
|
| Gene Name
| DPH5 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in methyltransferase activity |
| Specific Function
| S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis (By similarity).
|
| GO Classification
|
| Biological Process |
| peptidyl-diphthamide biosynthetic process from peptidyl-histidine |
| Function |
| catalytic activity |
| transferase activity |
| s-adenosylmethionine-dependent methyltransferase activity |
| diphthine synthase activity |
| transferase activity, transferring one-carbon groups |
| methyltransferase activity |
| Molecular Function |
| diphthine synthase activity |
| Process |
| metabolic process |
| macromolecule metabolic process |
| peptidyl-histidine modification |
| peptidyl-diphthamide metabolic process |
| peptidyl-diphthamide biosynthetic process from peptidyl-histidine |
| macromolecule modification |
| protein modification process |
| peptidyl-amino acid modification |
|
| Cellular Location
|
Not Available
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | peptidyl-diphthamide biosynthesis | Not Available | Not Available |
|
| Gene Properties |
|---|
| Chromosome Location
| 1 |
| Locus
| 1p21.2 |
| SNPs
| DPH5 |
| Gene Sequence
|
>858 bp
ATGCTTTATCTCATCGGGTTGGGCCTGGGAGATGCCAAGGACATCACAGTCAAGGGCCTG
GAAGTTGTTAGACGCTGCAGTCGAGTGTATCTGGAAGCCTACACCTCAGTCCTAACTGTA
GGGAAGGAAGCCTTGGAAGAGTTTTATGGAAGAAAATTGGTTGTTGCTGATAGAGAAGAA
GTGGAACAAGAAGCAGATAATATTTTAAAGGATGCTGATATCAGTGATGTTGCATTCCTT
GTGGTTGGTGATCCATTTGGGGCCACAACACACAGTGATCTTGTTCTAAGAGCAACAAAG
CTGGGAATTCCTTATAGAGTTATTCACAATGCCTCCATAATGAATGCTGTAGGCTGCTGT
GGTTTACAGTTATATAAGTTTGGAGAGACAGTTTCTATTGTTTTTTGGACAGACACTTGG
AGACCAGAAAGCTTCTTTGACAAAGTGAAGAAGAACAGACAAAATGGCATGCACACATTA
TGTTTACTAGACATCAAAGTAAAGGAGCAGTCTTTGGAAAATCTAATCAAGGGAAGGAAG
ATCTATGAACCTCCACGGTATATGAGTGTAAACCAAGCAGCCCAGCAGCTTCTGGAGATT
GTTCAAAATCAAAGAATACGAGGAGAAGAACCAGCAGTTACCGAGGAGACACTTTGTGTT
GGCTTAGCCAGGGTTGGAGCCGACGACCAGAAAATTGCAGCAGGCACTTTAAGGCAAATG
TGCACTGTGGACTTGGGAGAACCATTGCATTCCTTGATCATCACAGGAGGCAGCATACAT
CCAATGGAGATGGAGATGCTAAGTCTGTTTTCCATACCAGAAAATAGCTCAGAATCTCAA
AGCATCAATGGACTTTGA
|
| Protein Properties |
|---|
| Number of Residues
| 285 |
| Molecular Weight
| 31651.17 |
| Theoretical pI
| 5.307 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Diphthine synthase
MLYLIGLGLGDAKDITVKGLEVVRRCSRVYLEAYTSVLTVGKEALEEFYGRKLVVADREE
VEQEADNILKDADISDVAFLVVGDPFGATTHSDLVLRATKLGIPYRVIHNASIMNAVGCC
GLQLYKFGETVSIVFWTDTWRPESFFDKVKKNRQNGMHTLCLLDIKVKEQSLENLIKGRK
IYEPPRYMSVNQAAQQLLEIVQNQRIRGEEPAVTEETLCVGLARVGADDQKIAAGTLRQM
CTVDLGEPLHSLIITGGSIHPMEMEMLSLFSIPENSSESQSINGL
|
| External Links |
|---|
| GenBank ID Protein
| 117190326 |
| UniProtKB/Swiss-Prot ID
| Q9H2P9 |
| UniProtKB/Swiss-Prot Entry Name
| DPH5_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_001077394.1 |
| GeneCard ID
| DPH5 |
| GenAtlas ID
| DPH5 |
| HGNC ID
| HGNC:24270 |
| References |
|---|
| General References
| Not Available |