Cannabis Compound Database: Showing Protein Phenylethanolamine N-methyltransferase (CDBP00398)

Identification Biological properties Gene properties Protein properties External links References XML Show 2 compounds

Identification

HMDB Protein ID

CDBP00398

Secondary Accession Numbers

Not Available

Name

Phenylethanolamine N-methyltransferase

Description

Not Available

Synonyms

Noradrenaline N-methyltransferase
PNMTase

Gene Name

PNMT

Protein Type

Enzyme

Biological Properties

General Function

Involved in methyltransferase activity

Specific Function

Converts noradrenaline to adrenaline.

GO Classification

Biological Process
cellular nitrogen compound metabolic process
epinephrine biosynthetic process
catecholamine biosynthetic process
Cellular Component
cytosol
Function
methyltransferase activity
catalytic activity
transferase activity
transferase activity, transferring one-carbon groups
Molecular Function
phenylethanolamine N-methyltransferase activity

Cellular Location

Not Available

Pathways

Name	SMPDB/Pathwhiz	KEGG
(R)-adrenaline biosynthesis	Not Available	Not Available
Catecholamine Biosynthesis
Aromatic L-Aminoacid Decarboxylase Deficiency		Not Available
Tyrosine hydroxylase deficiency		Not Available
Tyrosine Metabolism

Gene Properties

Chromosome Location

Locus

17q

SNPs

PNMT

Gene Sequence

>849 bp
ATGAGCGGCGCAGACCGTAGCCCCAATGCGGGCGCAGCCCCTGACTCGGCCCCGGGCCAG
GCGGCGGTGGCTTCGGCCTACCAGCGCTTCGAGCCGCGCGCCTACCTCCGCAACAACTAC
GCGCCCCCTCGCGGGGACCTGTGCAACCCGAACGGCGTCGGGCCGTGGAAGCTGCGCTGC
TTGGCGCAGACCTTCGCCACCGGTGAAGTGTCCGGACGCACCCTCATCGACATTGGTTCA
GGCCCCACCGTGTACCAGCTGCTCAGTGCCTGCAGCCACTTTGAGGACATCACCATGACA
GATTTCCTGGAGGTCAACCGCCAGGAGCTGGGGCGCTGGCTGCAGGAGGAGCCGGGGGCC
TTCAACTGGAGCATGTACAGCCAACATGCCTGCCTCATTGAGGGCAAGGGGGAATGCTGG
CAGGATAAGGAGCGCCAGCTGCGAGCCAGGGTGAAACGGGTCCTGCCCATCGACGTGCAC
CAGCCCCAGCCCCTGGGTGCTGGGAGCCCAGCTCCCCTGCCTGCTGACGCCCTGGTCTCT
GCCTTCTGCTTGGAGGCTGTGAGCCCAGATCTTGCCAGCTTTCAGCGGGCCCTGGACCAC
ATCACCACGCTGCTGAGGCCTGGGGGGCACCTCCTCCTCATCGGGGCCCTGGAGGAGTCG
TGGTACCTGGCTGGGGAGGCCAGGCTGACGGTGGTGCCAGTGTCTGAGGAGGAGGTGAGG
GAGGCCCTGGTGCGTAGTGGCTACAAGGTCCGGGACCTCCGCACCTATATCATGCCTGCC
CACCTTCAGACAGGCGTAGATGATGTCAAGGGCGTCTTCTTCGCCTGGGCTCAGAAGGTT
GGGCTGTGA

Protein Properties

Number of Residues

282

Molecular Weight

30854.745

Theoretical pI

6.072

Pfam Domain Function

NNMT_PNMT_TEMT (PF01234 )

Signals

Not Available

Transmembrane Regions

Not Available

Protein Sequence

>Phenylethanolamine N-methyltransferase
MSGADRSPNAGAAPDSAPGQAAVASAYQRFEPRAYLRNNYAPPRGDLCNPNGVGPWKLRC
LAQTFATGEVSGRTLIDIGSGPTVYQLLSACSHFEDITMTDFLEVNRQELGRWLQEEPGA
FNWSMYSQHACLIEGKGECWQDKERQLRARVKRVLPIDVHQPQPLGAGSPAPLPADALVS
AFCLEAVSPDLASFQRALDHITTLLRPGGHLLLIGALEESWYLAGEARLTVVPVSEEEVR
EALVRSGYKVRDLRTYIMPAHLQTGVDDVKGVFFAWAQKVGL

External Links

GenBank ID Protein

Not Available

UniProtKB/Swiss-Prot ID

P11086

UniProtKB/Swiss-Prot Entry Name

PNMT_HUMAN

PDB IDs