| Identification |
|---|
| HMDB Protein ID
| CDBP00395 |
| Secondary Accession Numbers
| Not Available |
| Name
| Glycine N-methyltransferase |
| Description
| Not Available |
| Synonyms
|
Not Available
|
| Gene Name
| GNMT |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in folic acid binding |
| Specific Function
| Catalyzes the methylation of glycine by using S-adenosylmethionine (AdoMet) to form N-methylglycine (sarcosine) with the concomitant production of S-adenosylhomocysteine (AdoHcy). Possible crucial role in the regulation of tissue concentration of AdoMet and of metabolism of methionine.
|
| GO Classification
|
| Biological Process |
| methionine metabolic process |
| one-carbon metabolic process |
| regulation of gluconeogenesis |
| S-adenosylhomocysteine metabolic process |
| cellular protein modification process |
| glycogen metabolic process |
| S-adenosylmethionine metabolic process |
| protein homotetramerization |
| Cellular Component |
| cytosol |
| cytoplasm |
| nucleus |
| Component |
| cell part |
| intracellular part |
| cytoplasm |
| Function |
| transferase activity, transferring one-carbon groups |
| methyltransferase activity |
| n-methyltransferase activity |
| binding |
| catalytic activity |
| transferase activity |
| glycine n-methyltransferase activity |
| folic acid binding |
| carboxylic acid binding |
| amino acid binding |
| Molecular Function |
| folic acid binding |
| glycine binding |
| glycine N-methyltransferase activity |
| Process |
| metabolic process |
| cellular metabolic process |
| sulfur amino acid metabolic process |
| methionine metabolic process |
| cellular amino acid and derivative metabolic process |
| cellular amino acid metabolic process |
|
| Cellular Location
|
- Cytoplasm
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Glycine and Serine Metabolism |    |  | | Glycine, serine and threonine metabolism | Not Available | | | Dimethylglycine Dehydrogenase Deficiency |    | Not Available | | Dihydropyrimidine Dehydrogenase Deficiency (DHPD) |    | Not Available | | Sarcosinemia |    | Not Available |
|
| Gene Properties |
|---|
| Chromosome Location
| 6 |
| Locus
| 6p12 |
| SNPs
| GNMT |
| Gene Sequence
|
>888 bp
ATGGTGGACAGCGTGTACCGGACCCGCTCCCTGGGGGTGGCGGCCGAAGGGCTCCCGGAC
CAGTACGCGGACGGGGAGGCGGCGCGCGTGTGGCAGCTGTATATCGGAGACACCCGCAGC
CGCACCGCCGAGTACAAGGCATGGCTGCTTGGGCTGCTGCGCCAGCACGGCTGCCAGCGG
GTGCTCGACGTAGCCTGTGGCACTGGGGTGGACTCCATTATGCTGGTGGAAGAGGGCTTC
AGTGTGACGAGTGTGGATGCCAGTGACAAGATGCTGAAGTATGCACTTAAGGAGCGCTGG
AACCGGCGGCACGAGCCCGCCTTCGACAAGTGGGTCATCGAAGAAGCCAACTGGATGACT
CTGGACAAAGATGTGCCCCAGTCAGCAGAGGGTGGCTTTGATGCTGTCATCTGCCTTGGA
AACAGTTTCGCTCACTTGCCAGACTGCAAAGGGGACCAGAGTGAGCACCGGCTGGCGCTG
AAAAACATTGCGAGCATGGTGCGGGCAGGGGGCCTACTGGTCATTGATCATCGCAACTAC
GACCACATCCTCAGTACAGGCTGTGCACCCCCAGGGAAGAACATCTACTATAAGAGTGAC
TTGACCAAGGACGTCACAACATCAGTGCTGATAGTGAACAACAAGGCCCACATGGTGACC
CTGGACTATACGGTGCAGGTGCCGGGGGCTGGCCAGGATGGCTCTCCTGGCTTGAGTAAG
TTCCGGCTCTCCTACTACCCACACTGTCTGGCATCCTTCACGGAGCTGCTCCAAGCAGCC
TTCGGAGGTAAGTGCCAGCACAGCGTCCTGGGCGACTTCAAGCCTTACAAGCCAGGCCAA
ACCTACATTCCCTGCTACTTCATCCACGTGCTCAAGAGGACAGACTGA
|
| Protein Properties |
|---|
| Number of Residues
| 295 |
| Molecular Weight
| 32742.0 |
| Theoretical pI
| 7.023 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Glycine N-methyltransferase
MVDSVYRTRSLGVAAEGLPDQYADGEAARVWQLYIGDTRSRTAEYKAWLLGLLRQHGCQR
VLDVACGTGVDSIMLVEEGFSVTSVDASDKMLKYALKERWNRRHEPAFDKWVIEEANWMT
LDKDVPQSAEGGFDAVICLGNSFAHLPDCKGDQSEHRLALKNIASMVRAGGLLVIDHRNY
DHILSTGCAPPGKNIYYKSDLTKDVTTSVLIVNNKAHMVTLDYTVQVPGAGQDGSPGLSK
FRLSYYPHCLASFTELLQAAFGGKCQHSVLGDFKPYKPGQTYIPCYFIHVLKRTD
|
| External Links |
|---|
| GenBank ID Protein
| 8671584 |
| UniProtKB/Swiss-Prot ID
| Q14749 |
| UniProtKB/Swiss-Prot Entry Name
| GNMT_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| AF101477 |
| GeneCard ID
| GNMT |
| GenAtlas ID
| GNMT |
| HGNC ID
| HGNC:4415 |
| References |
|---|
| General References
| Not Available |