| Identification |
|---|
| HMDB Protein ID
| CDBP00393 |
| Secondary Accession Numbers
| Not Available |
| Name
| Cytochrome P450 4A11 |
| Description
| Not Available |
| Synonyms
|
- 20-HETE synthase
- 20-hydroxyeicosatetraenoic acid synthase
- CYP4AII
- CYPIVA11
- Cytochrome P-450HK-omega
- Cytochrome P450HL-omega
- Fatty acid omega-hydroxylase
- Lauric acid omega-hydroxylase
|
| Gene Name
| CYP4A11 |
| Protein Type
| Metal Binding |
| Biological Properties |
|---|
| General Function
| Involved in monooxygenase activity |
| Specific Function
| Catalyzes the omega- and (omega-1)-hydroxylation of various fatty acids such as laurate, myristate and palmitate. Has little activity toward prostaglandins A1 and E1. Oxidizes arachidonic acid to 20-hydroxyeicosatetraenoic acid (20-HETE).
|
| GO Classification
|
| Biological Process |
| xenobiotic metabolic process |
| renal water homeostasis |
| sodium ion homeostasis |
| epoxygenase P450 pathway |
| positive regulation of icosanoid secretion |
| pressure natriuresis |
| Cellular Component |
| endoplasmic reticulum membrane |
| apical plasma membrane |
| Function |
| cation binding |
| metal ion binding |
| binding |
| catalytic activity |
| transition metal ion binding |
| electron carrier activity |
| iron ion binding |
| monooxygenase activity |
| heme binding |
| oxidoreductase activity |
| ion binding |
| Molecular Function |
| leukotriene-B4 20-monooxygenase activity |
| electron carrier activity |
| iron ion binding |
| heme binding |
| alkane 1-monooxygenase activity |
| arachidonic acid epoxygenase activity |
| arachidonic acid omega-hydroxylase activity |
| Process |
| metabolic process |
| oxidation reduction |
|
| Cellular Location
|
- Peripheral membrane protein
- Peripheral membrane protein
- Endoplasmic reticulum membrane
- Microsome membrane
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | PPAR signaling pathway | Not Available |  | | Vascular smooth muscle contraction | Not Available |  | | Arachidonic Acid Metabolism |    |  | | Leukotriene C4 Synthesis Deficiency |    | Not Available | | Piroxicam Action Pathway |    | Not Available |
|
| Gene Properties |
|---|
| Chromosome Location
| 1 |
| Locus
| 1p33 |
| SNPs
| CYP4A11 |
| Gene Sequence
|
>1560 bp
ATGAGTGTCTCTGTGCTGAGCCCCAGCAGACTCCTGGGTGATGTCTCTGGAATCCTCCAA
GCGGCCTCCCTGCTCATTCTGCTTCTGCTGCTGATCAAGGCAGTTCAGCTCTACCTGCAC
AGGCAGTGGCTGCTCAAAGCCCTCCAGCAGTTCCCGTGCCCTCCCTCCCACTGGCTCTTC
GGGCACATCCAGGAGCTCCAACAGGACCAGGAGCTACAACGGATTCAGAAATGGGTGGAG
ACATTCCCAAGTGCCTGTCCTCATTGGCTATGGGGAGGCAAAGTTCGTGTCCAGCTCTAT
GACCCTGACTATATGAAGGTGATTCTGGGGAGATCAGACCCGAAATCCCATGGTTCCTAC
AGATTCCTGGCTCCATGGATTGGGTACGGCTTGCTCCTGTTGAATGGGCAGACATGGTTC
CAGCATCGACGGATGCTGACCCCAGCCTTCCACTATGACATCCTGAAGCCCTATGTGGGG
CTCATGGCAGACTCTGTACGAGTGATGCTGGACAAATGGGAAGAGCTCCTTGGCCAGGAT
TCCCCTCTGGAGGTCTTTCAGCACGTCTCCTTGATGACCCTGGACACCATCATGAAGTGT
GCCTTCAGCCATCAGGGCAGCATCCAGGTGGACAGGAATTCTCAGTCCTACATACAGGCC
ATTAGTGACCTGAACAACCTGGTTTTTTCCCGTGTGAGGAATGCCTTTCACCAGAATGAC
ACCATCTACAGCCTGACCTCTGCTGGCCGCTGGACACACCGCGCCTGCCAGCTGGCCCAT
CAGCACACAGACCAAGTGATCCAACTGAGGAAGGCTCAACTACAGAAGGAGGGGGAGCTG
GAGAAGATCAAGAGGAAGAGGCATTTGGATTTTCTGGATATCCTCCTCTTGGCCAAAATG
GAGAATGGGAGCATCTTGTCAGACAAGGACCTCCGTGCTGAGGTGGACACGTTCATGTTT
GAGGGCCACGACACCACAGCCAGTGGGATCTCCTGGATCCTCTATGCTCTGGCCACACAC
CCCAAGCATCAGGAGAGGTGCCGGGAGGAGATCCACAGCCTCCTGGGTGATGGAGCCTCC
ATCACCTGGAACCACCTGGACCAGATGCCCTACACCACCATGTGCATTAAGGAGGCACTG
AGGCTCTACCCACCGGTGCCAGGCATTGGCAGAGAGCTCAGCACTCCCGTCACCTTCCCT
GATGGGCGCTCCTTGCCCAAAGGTATCATGGTCCTCCTCTCCATTTATGGCCTTCACCAC
AACCCAAAAGTGTGGCCCAACCCAGAGGTGTTTGACCCTTTCCGTTTTGCACCGGGTTCT
GCTCAACACAGCCACGCTTTCCTGCCCTTCTCAGGAGGATCAAGGAACTGCATTGGGAAA
CAATTTGCCATGAACGAGCTGAAGGTGGCCACGGCCCTGACCCTGCTCCGCTTTGAGCTG
CTGCCTGATCCCACCAGGATCCCCATCCCCATTGCACGACTTGTGTTGAAATCCAAAAAT
GGAATCCACCTGCGTCTCAGGAGGCTCCCTAACCCTTGTGAAGACAAGGACCAGCTTTGA
|
| Protein Properties |
|---|
| Number of Residues
| 519 |
| Molecular Weight
| 59347.31 |
| Theoretical pI
| 8.764 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Cytochrome P450 4A11
MSVSVLSPSRLLGDVSGILQAASLLILLLLLIKAVQLYLHRQWLLKALQQFPCPPSHWLF
GHIQELQQDQELQRIQKWVETFPSACPHWLWGGKVRVQLYDPDYMKVILGRSDPKSHGSY
RFLAPWIGYGLLLLNGQTWFQHRRMLTPAFHYDILKPYVGLMADSVRVMLDKWEELLGQD
SPLEVFQHVSLMTLDTIMKCAFSHQGSIQVDRNSQSYIQAISDLNNLVFSRVRNAFHQND
TIYSLTSAGRWTHRACQLAHQHTDQVIQLRKAQLQKEGELEKIKRKRHLDFLDILLLAKM
ENGSILSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPKHQERCREEIHSLLGDGAS
ITWNHLDQMPYTTMCIKEALRLYPPVPGIGRELSTPVTFPDGRSLPKGIMVLLSIYGLHH
NPKVWPNPEVFDPFRFAPGSAQHSHAFLPFSGGSRNCIGKQFAMNELKVATALTLLRFEL
LPDPTRIPIPIARLVLKSKNGIHLRLRRLPNPCEDKDQL
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| Q02928 |
| UniProtKB/Swiss-Prot Entry Name
| CP4AB_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| L04751 |
| GeneCard ID
| CYP4A11 |
| GenAtlas ID
| CYP4A11 |
| HGNC ID
| HGNC:2642 |
| References |
|---|
| General References
| Not Available |