Cannabis Compound Database: Showing Protein 3-hydroxyisobutyrate dehydrogenase, mitochondrial (CDBP00387)

Identification Biological properties Gene properties Protein properties External links References XML Show 5 compounds

Identification

HMDB Protein ID

CDBP00387

Secondary Accession Numbers

Not Available

Name

3-hydroxyisobutyrate dehydrogenase, mitochondrial

Description

Not Available

Synonyms

HIBADH

Gene Name

HIBADH

Protein Type

Enzyme

Biological Properties

General Function

Involved in 3-hydroxyisobutyrate dehydrogenase activity

Specific Function

Not Available

GO Classification

Biological Process
branched-chain amino acid catabolic process
cellular nitrogen compound metabolic process
pentose-phosphate shunt
valine metabolic process
Cellular Component
mitochondrial matrix
Function
3-hydroxyisobutyrate dehydrogenase activity
oxidoreductase activity, acting on ch-oh group of donors
oxidoreductase activity
binding
nucleotide binding
catalytic activity
nad or nadh binding
oxidoreductase activity, acting on the ch-oh group of donors, nad or nadp as acceptor
coenzyme binding
cofactor binding
phosphogluconate dehydrogenase (decarboxylating) activity
Molecular Function
3-hydroxyisobutyrate dehydrogenase activity
NAD binding
phosphogluconate dehydrogenase (decarboxylating) activity
Process
cellular amino acid and derivative metabolic process
cellular amino acid metabolic process
branched chain family amino acid metabolic process
valine metabolic process
metabolic process
pentose-phosphate shunt
cellular metabolic process
small molecule metabolic process
alcohol metabolic process
monosaccharide metabolic process
hexose metabolic process
glucose metabolic process
oxidation reduction
glucose catabolic process

Cellular Location

Mitochondrion

Pathways

Name	SMPDB/Pathwhiz	KEGG
Valine, Leucine and Isoleucine Degradation
Beta-Ketothiolase Deficiency		Not Available
2-Methyl-3-Hydroxybutryl CoA Dehydrogenase Deficiency		Not Available
Propionic Acidemia		Not Available
3-Hydroxy-3-Methylglutaryl-CoA Lyase Deficiency		Not Available

Gene Properties

Chromosome Location

Locus

7p15.2

SNPs

HIBADH

Gene Sequence

>1011 bp
ATGGCAGCCTCCTTACGGCTCCTCGGAGCTGCCTCCGGTCTCCGGTACTGGAGCCGGCGG
CTGCGGCCGGCAGCCGGCAGCTTTGCAGCGGTGTGTTCTAGGTCAGTGGCTTCAAAGACT
CCAGTTGGATTCATTGGACTGGGCAACATGGGGAATCCAATGGCAAAAAATCTCATGAAA
CATGGCTATCCACTTATTATTTATGATGTGTTCCCTGATGCCTGCAAAGAGTTTCAAGAT
GCAGGTGAACAGGTAGTATCTTCCCCAGCAGATGTTGCTGAAAAAGCTGACAGAATTATT
ACAATGCTGCCCACCAGTATCAATGCAATAGAAGCTTATTCCGGAGCAAATGGGATTCTA
AAAAAAGTGAAGAAGGGCTCATTATTAATAGATTCCAGCACTATTGATCCTGCAGTTTCA
AAAGAATTGGCCAAAGAAGTTGAGAAAATGGGAGCAGTTTTCATGGATGCCCCTGTTTCT
GGTGGTGTAGGAGCTGCACGATCTGGGAACCTCACGTTTATGGTGGGAGGAGTTGAAGAT
GAATTTGCTGCTGCCCAAGAGTTGCTGGGGTGCATGGGCTCCAACGTGGTGTACTGTGGA
GCTGTTGGGACTGGGCAGGCGGCAAAGATCTGCAACAACATGCTGTTAGCTATTAGTATG
ATTGGAACTGCTGAAGCTATGAATCTTGGAATCAGGTTAGGGCTTGACCCAAAACTACTG
GCTAAAATCCTAAATATGAGCTCAGGACGGTGTTGGTCAAGTGACACTTATAATCCTGTA
CCTGGAGTGATGGATGGCGTTCCCTCGGCTAATAACTATCAGGGTGGATTTGGAACAACA
CTCATGGCTAAGGATCTGGGATTGGCACAAGACTCTGCTACCAGCACAAAGAGCCCAATC
CTTCTTGGCAGTCTGGCCCATCAGATCTACAGGATGATGTGTGCAAAGGGCTACTCAAAG
AAAGACTTCTCATCCGTGTTCCAGTTCCTACGAGAGGAGGAGACCTTCTGA

Protein Properties

Number of Residues

336

Molecular Weight

35328.515

Theoretical pI

8.129

Pfam Domain Function

NAD_binding_2 (PF03446 )

Signals

Not Available

Transmembrane Regions

Not Available

Protein Sequence

>3-hydroxyisobutyrate dehydrogenase, mitochondrial
MAASLRLLGAASGLRYWSRRLRPAAGSFAAVCSRSVASKTPVGFIGLGNMGNPMAKNLMK
HGYPLIIYDVFPDACKEFQDAGEQVVSSPADVAEKADRIITMLPTSINAIEAYSGANGIL
KKVKKGSLLIDSSTIDPAVSKELAKEVEKMGAVFMDAPVSGGVGAARSGNLTFMVGGVED
EFAAAQELLGCMGSNVVYCGAVGTGQAAKICNNMLLAISMIGTAEAMNLGIRLGLDPKLL
AKILNMSSGRCWSSDTYNPVPGVMDGVPSANNYQGGFGTTLMAKDLGLAQDSATSTKSPI
LLGSLAHQIYRMMCAKGYSKKDFSSVFQFLREEETF

External Links

GenBank ID Protein

21619591

UniProtKB/Swiss-Prot ID

P31937

UniProtKB/Swiss-Prot Entry Name

3HIDH_HUMAN

PDB IDs