| Identification |
|---|
| HMDB Protein ID
| CDBP00377 |
| Secondary Accession Numbers
| Not Available |
| Name
| GDP-mannose 4,6 dehydratase |
| Description
| Not Available |
| Synonyms
|
- GDP-D-mannose dehydratase
- GMD
|
| Gene Name
| GMDS |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in catalytic activity |
| Specific Function
| Conversion of GDP-D-mannose to GDP-4-keto-6-D-deoxymannose.
|
| GO Classification
|
| Biological Process |
| Notch signaling pathway |
| GDP-mannose metabolic process |
| 'de novo' GDP-L-fucose biosynthetic process |
| Cellular Component |
| cytoplasm |
| Component |
| cell part |
| intracellular |
| Function |
| binding |
| catalytic activity |
| lyase activity |
| coenzyme binding |
| carbon-oxygen lyase activity |
| hydro-lyase activity |
| cofactor binding |
| gdp-mannose 4,6-dehydratase activity |
| Molecular Function |
| GDP-mannose 4,6-dehydratase activity |
| NADP+ binding |
| Process |
| alcohol metabolic process |
| gdp-mannose metabolic process |
| monosaccharide metabolic process |
| hexose metabolic process |
| metabolic process |
| mannose metabolic process |
| cellular metabolic process |
| small molecule metabolic process |
|
| Cellular Location
|
Not Available
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | GDP-L-fucose biosynthesis via de novo pathway | Not Available | Not Available | | Fructose and mannose metabolism | Not Available |  | | Amino sugar and nucleotide sugar metabolism | Not Available |  | | Fructose and Mannose Degradation |    | | | Fructosuria |    | Not Available |
|
| Gene Properties |
|---|
| Chromosome Location
| 6 |
| Locus
| 6p25 |
| SNPs
| GMDS |
| Gene Sequence
|
>1119 bp
ATGGCACACGCACCGGCACGCTGCCCCAGCGCCCGGGGCTCCGGGGACGGCGAGATGGGC
AAGCCCAGGAACGTGGCGCTCATCACCGGTATCACAGGCCAGGATGGTTCCTACCTGGCT
GAGTTCCTGCTGGAGAAAGGCTATGAGGTCCATGGAATTGTACGGCGGTCCAGTTCATTT
AATACGGGTCGAATTGAGCATCTGTATAAGAATCCCCAGGCTCACATTGAAGGAAACATG
AAGTTGCACTATGGCGATCTCACTGACAGTACCTGCCTTGTGAAGATCATTAATGAAGTA
AAGCCCACAGAGATCTACAACCTTGGAGCCCAGAGCCACGTCAAAATTTCCTTTGACCTC
GCTGAGTACACTGCGGACGTTGACGGAGTTGGCACTCTACGACTTCTAGATGCAGTTAAG
ACTTGTGGCCTTATCAACTCTGTGAAGTTCTACCAAGCCTCAACAAGTGAACTTTATGGG
AAAGTGCAGGAAATACCCCAGAAGGAGACCACCCCTTTCTATCCCCGGTCACCCTATGGG
GCAGCAAAACTCTATGCCTATTGGATTGTGGTGAACTTCCGTGAGGCGTATAATCTCTTT
GCAGTGAACGGCATTCTCTTCAATCATGAGAGTCCCAGAAGAGGAGCTAATTTCGTTACT
CGAAAAATTAGCCGGTCAGTAGCTAAGATTTACCTTGGACAACTGGAATGTTTCAGTTTG
GGAAATCTGGATGCCAAACGAGATTGGGGCCATGCCAAGGACTATGTGGAGGCTATGTGG
TTGATGTTGCAGAATGATGAGCCGGAGGACTTCGTTATAGCTACTGGGGAGGTCCATAGT
GTCCGGGAATTTGTCGAGAAATCATTCTTGCACATTGGAAAAACCATTGTGTGGGAAGGA
AAGAATGAAAATGAAGTGGGCAGATGTAAAGAGACCGGCAAAGTTCACGTGACTGTGGAT
CTCAAGTACTACCGGCCAACTGAAGTGGACTTTCTGCAGGGCGACTGCACCAAAGCGAAA
CAGAAGCTGAACTGGAAGCCCCGGGTCGCTTTCGATGAGCTGGTGAGGGAGATGGTGCAC
GCCGACGTGGAGCTCATGAGGACAAACCCCAATGCCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 372 |
| Molecular Weight
| 39053.295 |
| Theoretical pI
| 7.081 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>GDP-mannose 4,6 dehydratase
MAHAPARCPSARGSGDGEMGKPRNVALITGITGQDGSYLAEFLLEKGYEVHGIVRRSSSF
NTGRIEHLYKNPQAHIEGNMKLHYGDLTDSTCLVKIINEVKPTEIYNLGAQSHVKISFDL
AEYTADVDGVGTLRLLDAVKTCGLINSVKFYQASTSELYGKVQEIPQKETTPFYPRSPYG
AAKLYAYWIVVNFREAYNLFAVNGILFNHESPRRGANFVTRKISRSVAKIYLGQLECFSL
GNLDAKRDWGHAKDYVEAMWLMLQNDEPEDFVIATGEVHSVREFVEKSFLHIGKTIVWEG
KNENEVGRCKETGKVHVTVDLKYYRPTEVDFLQGDCTKAKQKLNWKPRVAFDELVREMVH
ADVELMRTNPNA
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| O60547 |
| UniProtKB/Swiss-Prot Entry Name
| GMDS_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| AF042377 |
| GeneCard ID
| GMDS |
| GenAtlas ID
| GMDS |
| HGNC ID
| HGNC:4369 |
| References |
|---|
| General References
| Not Available |