| Identification |
|---|
| HMDB Protein ID
| CDBP00376 |
| Secondary Accession Numbers
| Not Available |
| Name
| Dolichol-phosphate mannosyltransferase |
| Description
| Not Available |
| Synonyms
|
- DPM synthase
- Dolichol-phosphate mannose synthase
- Dolichyl-phosphate beta-D-mannosyltransferase
- MPD synthase
- Mannose-P-dolichol synthase
|
| Gene Name
| DPM1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Cell wall/membrane/envelope biogenesis |
| Specific Function
| Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins.
|
| GO Classification
|
| Biological Process |
| dolichol metabolic process |
| GDP-mannose metabolic process |
| protein O-linked mannosylation |
| GPI anchor biosynthetic process |
| dolichol-linked oligosaccharide biosynthetic process |
| protein N-linked glycosylation via asparagine |
| C-terminal protein lipidation |
| Cellular Component |
| endoplasmic reticulum membrane |
| dolichol-phosphate-mannose synthase complex |
| Molecular Function |
| alcohol binding |
| dolichyl-phosphate beta-D-mannosyltransferase activity |
| dolichyl-phosphate-mannose-protein mannosyltransferase activity |
| mannose binding |
|
| Cellular Location
|
- Endoplasmic reticulum
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | protein glycosylation | Not Available | Not Available | | N-Glycan biosynthesis | Not Available |  |
|
| Gene Properties |
|---|
| Chromosome Location
| 20 |
| Locus
| 20q13.13 |
| SNPs
| DPM1 |
| Gene Sequence
|
>783 bp
ATGGCCTCCTTGGAAGTCAGTCGTAGTCCTCGCAGGTCTCGGCGGGAGCTGGAAGTGCGC
AGTCCACGACAGAACAAATATTCGGTGCTTTTACCTACCTACAACGAGCGCGAGAACCTG
CCGCTCATCGTGTGGCTGCTGGTGAAAAGCTTCTCCGAGAGTGGAATCAACTATGAAATT
ATAATCATAGATGATGGAAGCCCAGATGGAACAAGGGATGTTGCTGAACAGTTGGAGAAG
ATCTATGGGTCAGACAGAATTCTTCTAAGACCACGAGAGAAAAAGTTGGGACTAGGAACT
GCATATATTCATGGAATGAAACATGCCACAGGAAACTACATCATTATTATGGATGCTGAT
CTCTCACACCATCCAAAATTTATTCCTGAATTTATTAGGAAGCAAAAGGAGGGTAATTTT
GATATTGTCTCTGGAACTCGCTACAAAGGAAATGGAGGTGTATATGGCTGGGATTTGAAA
AGAAAAATAATCAGCCGTGGGGCCAATTTTTTAACTCAGATCTTGCTGAGACCAGGAGCA
TCTGATTTAACAGGAAGTTTCAGATTATACCGAAAAGAAGTTCTAGAGAAATTAATAGAA
AAATGTGTTTCTAAAGGCTACGTCTTCCAGATGGAGATGATTGTTCGGGCAAGACAGTTG
AATTATACTATTGGCGAGGTTCCAATATCATTTGTGGATCGTGTTTATGGTGAATCCAAG
TTGGGAGGAAATGAAATAGTATCTTTCTTGAAAGGATTATTGACTCTTTTTGCTACTACA
TAA
|
| Protein Properties |
|---|
| Number of Residues
| 260 |
| Molecular Weight
| 29633.995 |
| Theoretical pI
| 9.563 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Dolichol-phosphate mannosyltransferase
MASLEVSRSPRRSRRELEVRSPRQNKYSVLLPTYNERENLPLIVWLLVKSFSESGINYEI
IIIDDGSPDGTRDVAEQLEKIYGSDRILLRPREKKLGLGTAYIHGMKHATGNYIIIMDAD
LSHHPKFIPEFIRKQKEGNFDIVSGTRYKGNGGVYGWDLKRKIISRGANFLTQILLRPGA
SDLTGSFRLYRKEVLEKLIEKCVSKGYVFQMEMIVRARQLNYTIGEVPISFVDRVYGESK
LGGNEIVSFLKGLLTLFATT
|
| External Links |
|---|
| GenBank ID Protein
| 4503363 |
| UniProtKB/Swiss-Prot ID
| O60762 |
| UniProtKB/Swiss-Prot Entry Name
| DPM1_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_003859.1 |
| GeneCard ID
| DPM1 |
| GenAtlas ID
| DPM1 |
| HGNC ID
| HGNC:3005 |
| References |
|---|
| General References
| Not Available |