Cannabis Compound Database: Showing Protein Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A (CDBP00356)

Identification Biological properties Gene properties Protein properties External links References XML Show 3 compounds

Identification

HMDB Protein ID

CDBP00356

Secondary Accession Numbers

Not Available

Name

Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A

Description

Not Available

Synonyms

Inositol polyphosphate 5-phosphatase J

Gene Name

INPP5J

Protein Type

Enzyme

Biological Properties

General Function

Involved in inositol or phosphatidylinositol phosphatase activity

Specific Function

Inositol 5-phosphatase, which converts inositol 1,4,5-trisphosphate to inositol 1,4-bisphosphate. Also converts phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol 4-phosphate and inositol 1,3,4,5-tetrakisphosphate to inositol 1,3,4-trisphosphate in vitro. May be involved in modulation of the function of inositol and phosphatidylinositol polyphosphate-binding proteins that are present at membranes ruffles (By similarity).

GO Classification

Biological Process
small molecule metabolic process
phosphatidylinositol biosynthetic process
negative regulation of microtubule polymerization
phosphatidylinositol phosphorylation
negative regulation of neuron projection development
negative regulation of peptidyl-serine phosphorylation
Cellular Component
cytosol
growth cone
ruffle
plasma membrane
dendritic shaft
Function
hydrolase activity, acting on ester bonds
catalytic activity
hydrolase activity
phosphoric ester hydrolase activity
phosphatase activity
inositol or phosphatidylinositol phosphatase activity
Molecular Function
inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity
inositol-1,4,5-trisphosphate 5-phosphatase activity
inositol-polyphosphate 5-phosphatase activity
phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity

Cellular Location

Cytoplasm

Pathways

Name	SMPDB/Pathwhiz	KEGG
Phosphatidylinositol signaling system	Not Available
Inositol Phosphate Metabolism
Inositol Metabolism

Gene Properties

Chromosome Location

Locus

22q12.2

SNPs

INPP5J

Gene Sequence

Not Available

Protein Properties

Number of Residues

1006

Molecular Weight

70238.575

Theoretical pI

8.673

Pfam Domain Function

Exo_endo_phos (PF03372 )

Signals

Not Available

Transmembrane Regions

Not Available

Protein Sequence

>Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A
MEGQSSRGSRRPGTRAGLGSLPMPQGVAQTGAPSKVDSSFQLPAKKNAALGPSEPRLALA
PVGPRAAMSASSEGPRLALASPRPILAPLCTPEGQKTATAHRSSSLAPTSVGQLVMSASA
GPKPPPATTGSVLAPTSLGLVMPASAGPRSPPVTLGPNLAPTSRDQKQEPPASVGPKPTL
AASGLSLALASEEQPPELPSTPSPVPSPVLSPTQEQALAPASTASGAASVGQTSARKRDA
PAPRPLPASEGHLQPPAQTSGPTGSPPCIQTSPDPRLSPSFRARPEALHSSPEDPVLPRP
PQTLPLDVGQGPSEPGTHSPGLLSPTFRPGAPSGQTVPPPLPKPPRSPSRSPSHSPNRSP
CVPPAPDMALPRLGTQSTGPGRCLSPNLQAQEAPAPVTTSSSTSTLSSSPWSAQPTWKSD
PGFRITVVTWNVGTAMPPDDVTSLLHLGGGDDSDGADMIAIGLQEVNSMLNKRLKDALFT
DQWSELFMDALGPFNFVLVSSVRMQGVILLLFAKYYHLPFLRDVQTDCTRTGLGGYWGNK
GGVSVRLAAFGHMLCFLNCHLPAHMDKAEQRKDNFQTILSLQQFQGPGAQGILDHDLVFW
FGDLNFRIESYDLHFVKFAIDSDQLHQLWEKDQLNMAKNTWPILKGFQEGPLNFAPTFKF
DVGTNKYDTSAKKRKPAWTDRILWKVKAPGGGPSPSGRKSHRLQVTQHSYRSHMEYTVSD
HKPVAAQFLLQFAFRDDMPLVRLEVADEWVRPEQAVVRYRMETVFARSSWDWIGLYRVGF
RHCKDYVAYVWAKHEDVDGNTYQVTFSEESLPKGHGDFILGYYSHNHSILIGITEPFQIS
LPSSELASSSTDSSGTSSEGEDDSTLELLAPKSRSPSPGKSKRHRSRSPGLARFPGLALR
PSSRERRGASRSPSPQSRRLSRVAPDRSSNGSSRGSSEEGPSGLPGPWAFPPAVPRSLGL
LPALRLETVDPGGGGSWGPDREALAPNSLSPSPQGHRGLEEGGLGP

External Links

GenBank ID Protein

50726960

UniProtKB/Swiss-Prot ID

Q15735

UniProtKB/Swiss-Prot Entry Name

PI5PA_HUMAN

PDB IDs

Not Available

GenBank Gene ID

Not Available

GeneCard ID