| Identification |
|---|
| HMDB Protein ID
| CDBP00350 |
| Secondary Accession Numbers
| Not Available |
| Name
| Uroporphyrinogen-III synthase |
| Description
| Not Available |
| Synonyms
|
- Hydroxymethylbilane hydrolyase [cyclizing]
- UROIIIS
- UROS
- Uroporphyrinogen-III cosynthase
|
| Gene Name
| UROS |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in uroporphyrinogen-III synthase activity |
| Specific Function
| Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III, the branch point for the various sub-pathways leading to the wide diversity of porphyrins. Porphyrins act as cofactors for a multitude of enzymes that perform a variety of processes within the cell such as methionine synthesis (vitamin B12) or oxygen transport (heme).
|
| GO Classification
|
| Biological Process |
| cellular response to arsenic-containing substance |
| heme biosynthetic process |
| protoporphyrinogen IX biosynthetic process |
| cellular response to amine stimulus |
| uroporphyrinogen III biosynthetic process |
| response to antibiotic |
| Cellular Component |
| mitochondrion |
| cytosol |
| Function |
| catalytic activity |
| lyase activity |
| carbon-oxygen lyase activity |
| hydro-lyase activity |
| uroporphyrinogen-iii synthase activity |
| Molecular Function |
| cofactor binding |
| uroporphyrinogen-III synthase activity |
| Process |
| metabolic process |
| biosynthetic process |
| cellular biosynthetic process |
| heterocycle biosynthetic process |
| tetrapyrrole biosynthetic process |
|
| Cellular Location
|
Not Available
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | protoporphyrin-IX biosynthesis | Not Available | Not Available | | Porphyrin and chlorophyll metabolism | Not Available |  | | Porphyrin Metabolism |    | | | Acute Intermittent Porphyria |    | Not Available | | Porphyria Variegata (PV) |    | Not Available |
|
| Gene Properties |
|---|
| Chromosome Location
| 10 |
| Locus
| 10q25.2-q26.3 |
| SNPs
| UROS |
| Gene Sequence
|
>798 bp
ATGAAGGTTCTTTTACTGAAGGATGCGAAGGAAGATGACTGTGGCCAGGATCCGTATATC
AGGGAATTAGGATTATATGGACTTGAAGCCACTTTGATCCCTGTTTTATCGTTTGAGTTT
TTGTCTCTTCCCAGTTTCTCTGAGAAGCTTTCTCATCCTGAAGATTACGGGGGACTCATT
TTTACCAGCCCCAGAGCAGTGGAAGCAGCAGAGTTATGTTTGGAGCAAAACAATAAAACT
GAAGTCTGGGAAAGGTCTCTGAAAGAAAAATGGAATGCCAAGTCAGTGTATGTGGTTGGA
AATGCTACTGCTTCTCTAGTGAGTAAAATTGGCCTGGATACAGAAGGAGAAACCTGTGGA
AATGCAGAAAAGCTTGCAGAATATATTTGTTCCAGGGAGTCCTCAGCACTGCCTCTTCTA
TTTCCCTGTGGAAACCTCAAAAGAGAAATCCTGCCAAAAGCGCTCAAGGACAAAGGGATT
GCCATGGAAAGCATAACTGTGTATCAGACAGTTGCACACCCAGGAATCCAAGGGAACCTG
AACAGCTACTATTCCCAGCAGGGGGTTCCAGCCAGCATCACATTTTTTAGTCCCTCTGGC
CTCACATACAGTCTCAAGCACATTCAGGAGTTATCTGGTGACAATATCGATCAAATTAAG
TTTGCAGCCATCGGCCCCACTACGGCTCGCGCGCTGGCCGCCCAGGGCCTTCCTGTAAGC
TGCACTGCAGAGAGCCCCACGCCACAAGCCCTGGCCACTGGCATCAGGAAGGCTCTCCAG
CCCCATGGCTGCTGCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 265 |
| Molecular Weight
| 28627.37 |
| Theoretical pI
| 5.471 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Uroporphyrinogen-III synthase
MKVLLLKDAKEDDCGQDPYIRELGLYGLEATLIPVLSFEFLSLPSFSEKLSHPEDYGGLI
FTSPRAVEAAELCLEQNNKTEVWERSLKEKWNAKSVYVVGNATASLVSKIGLDTEGETCG
NAEKLAEYICSRESSALPLLFPCGNLKREILPKALKDKGIAMESITVYQTVAHPGIQGNL
NSYYSQQGVPASITFFSPSGLTYSLKHIQELSGDNIDQIKFAAIGPTTARALAAQGLPVS
CTAESPTPQALATGIRKALQPHGCC
|
| External Links |
|---|
| GenBank ID Protein
| 337463 |
| UniProtKB/Swiss-Prot ID
| P10746 |
| UniProtKB/Swiss-Prot Entry Name
| HEM4_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| J03824 |
| GeneCard ID
| UROS |
| GenAtlas ID
| UROS |
| HGNC ID
| HGNC:12592 |
| References |
|---|
| General References
| Not Available |