| Identification |
|---|
| HMDB Protein ID
| CDBP00349 |
| Secondary Accession Numbers
| Not Available |
| Name
| Sulfotransferase 1A3/1A4 |
| Description
| Not Available |
| Synonyms
|
- Aryl sulfotransferase 1A3/1A4
- Catecholamine-sulfating phenol sulfotransferase
- HAST3
- M-PST
- Monoamine-sulfating phenol sulfotransferase
- Placental estrogen sulfotransferase
- ST1A3/ST1A4
- Sulfotransferase, monoamine-preferring
- TL-PST
- Thermolabile phenol sulfotransferase
|
| Gene Name
| SULT1A3 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in sulfotransferase activity |
| Specific Function
| Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of phenolic monoamines (neurotransmitters such as dopamine, norepinephrine and serotonin) and phenolic and catechol drugs.
|
| GO Classification
|
| Biological Process |
| catecholamine metabolic process |
| activation of signaling protein activity involved in unfolded protein response |
| flavonoid metabolic process |
| sulfation |
| steroid metabolic process |
| xenobiotic metabolic process |
| 3'-phosphoadenosine 5'-phosphosulfate metabolic process |
| Cellular Component |
| cytosol |
| Function |
| catalytic activity |
| transferase activity |
| transferase activity, transferring sulfur-containing groups |
| sulfotransferase activity |
| Molecular Function |
| aryl sulfotransferase activity |
|
| Cellular Location
|
- Cytoplasm
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | sulfur metabolism | Not Available |  | | Chemical carcinogenesis | Not Available |  | | Acetaminophen Metabolism Pathway |    | Not Available |
|
| Gene Properties |
|---|
| Chromosome Location
| 16 |
| Locus
| 16p11.2 |
| SNPs
| SULT1A3 |
| Gene Sequence
|
>888 bp
ATGGAGCTGATCCAGGACACCTCCCGCCCGCCACTGGAGTACGTGAAGGGGGTCCCGCTC
ATCAAGTACTTTGCAGAGGCACTGGGGCCCCTGCAGAGCTTCCAAGCCCGACCTGATGAC
CTGCTCATCAACACCTACCCCAAGTCTGGCACCACCTGGGTGAGCCAGATACTGGACATG
ATCTACCAGGGCGGCGACCTAGAGAAGTGTAACCGGGCTCCCATCTACGTACGGGTGCCC
TTCCTTGAGGTCAATGATCCAGGGGAACCCTCAGGGCTGGAGACTCTGAAAGACACACCG
CCCCCACGGCTCATCAAGTCACACCTGCCCCTGGCTCTGCTCCCTCAGACTCTGTTGGAT
CAGAAGGTCAAGGTGGTCTATGTTGCCCGAAACCCAAAGGACGTGGCGGTCTCCTACTAC
CATTTCCACCGTATGGAAAAGGCGCACCCTGAGCCTGGGACCTGGGACAGCTTCCTGGAA
AAGTTCATGGCTGGAGAAGTGTCCTACGGGTCCTGGTACCAGCACGTGCAGGAGTGGTGG
GAGCTGAGCCGCACCCACCCTGTTCTCTACCTCTTCTATGAAGACATGAAGGAGAACCCC
AAAAGGGAGATTCAAAAGATCCTGGAGTTTGTGGGGCGCTCCCTGCCAGAGGAGACCATG
GACTTCATGGTTCAGCACACGTCGTTCAAGGAGATGAAGAAGAACCCTATGACCAACTAC
ACCACCGTCCCCCAGGAGCTCATGGACCACAGCATCTCCCCCTTCATGAGGAAAGGCATG
GCTGGGGACTGGAAGACCACCTTCACCGTGGCGCAGAATGAGCGCTTCGATGCGGACTAT
GCGGAGAAGATGGCAGGCTGCAGCCTCAGCTTCCGCTCTGAGCTGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 295 |
| Molecular Weight
| 34195.96 |
| Theoretical pI
| 6.007 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Sulfotransferase 1A3/1A4
MELIQDTSRPPLEYVKGVPLIKYFAEALGPLQSFQARPDDLLINTYPKSGTTWVSQILDM
IYQGGDLEKCNRAPIYVRVPFLEVNDPGEPSGLETLKDTPPPRLIKSHLPLALLPQTLLD
QKVKVVYVARNPKDVAVSYYHFHRMEKAHPEPGTWDSFLEKFMAGEVSYGSWYQHVQEWW
ELSRTHPVLYLFYEDMKENPKREIQKILEFVGRSLPEETMDFMVQHTSFKEMKKNPMTNY
TTVPQELMDHSISPFMRKGMAGDWKTTFTVAQNERFDADYAEKMAGCSLSFRSEL
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| P50224 |
| UniProtKB/Swiss-Prot Entry Name
| ST1A3_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| L19956 |
| GeneCard ID
| SULT1A3 |
| GenAtlas ID
| SULT1A3 |
| HGNC ID
| HGNC:30004 |
| References |
|---|
| General References
| Not Available |