| Identification |
|---|
| HMDB Protein ID
| CDBP00347 |
| Secondary Accession Numbers
| Not Available |
| Name
| Protein-tyrosine sulfotransferase 2 |
| Description
| Not Available |
| Synonyms
|
- TPST-2
- Tyrosylprotein sulfotransferase 2
|
| Gene Name
| TPST2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in sulfotransferase activity |
| Specific Function
| Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides.
|
| GO Classification
|
| Biological Process |
| peptidyl-tyrosine sulfation |
| Cellular Component |
| endoplasmic reticulum |
| membrane |
| integral to membrane |
| Golgi membrane |
| Function |
| catalytic activity |
| transferase activity |
| transferase activity, transferring sulfur-containing groups |
| sulfotransferase activity |
| Molecular Function |
| protein-tyrosine sulfotransferase activity |
|
| Cellular Location
|
- Golgi apparatus membrane
- Single-pass type II membrane protein
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 22 |
| Locus
| 22q12.1 |
| SNPs
| TPST2 |
| Gene Sequence
|
>1134 bp
ATGCGCCTGTCGGTGCGGAGGGTGCTGCTGGCAGCCGGCTGCGCCCTGGTCCTGGTGCTG
GCGGTTCAGCTGGGACAGCAGGTGCTAGAGTGCCGGGCGGTGCTGGCGGGCCTGCGGAGC
CCCCGGGGGGCCATGCGGCCTGAGCAGGAGGAGCTGGTGATGGTGGGCACCAACCACGTG
GAATACCGCTATGGCAAGGCCATGCCGCTCATCTTCGTGGGTGGCGTGCCTCGCAGTGGC
ACCACGTTGATGCGCGCCATGCTGGACGCCCACCCCGAGGTGCGCTGCGGCGAGGAGACC
CGCATCATCCCGCGCGTGCTGGCCATGCGCCAGGCCTGGTCCAAGTCTGGCCGTGAGAAG
CTGCGGCTGGATGAGGCGGGGGTGACGGATGAGGTGCTGGACGCCGCCATGCAGGCCTTC
ATCCTGGAGGTGATTGCCAAGCACGGAGAGCCGGCCCGCGTGCTCTGCAACAAGGACCCA
TTTACGCTCAAGTCCTCGGTCTACCTGTCGCGCCTGTTCCCCAACTCCAAGTTCCTGCTG
ATGGTGCGGGACGGCCGGGCCTCCGTGCACTCCATGATCACGCGCAAAGTCACCATTGCG
GGCTTTGACCTCAGCAGCTACCGTGACTGCCTCACCAAGTGGAACAAGGCCATCGAGGTG
ATGTACGCCCAGTGCATGGAGGTAGGCAAGGAGAAGTGCTTGCCTGTGTACTACGAGCAG
CTGGTGCTGCACCCCAGGCGCTCACTCAAGCTCATCCTCGACTTCCTCGGCATCGCCTGG
AGCGACGCTGTCCTCCACCATGAAGACCTCATTGGCAAGCCCGGTGGTGTCTCCCTGTCC
AAGATCGAGCGGTCCACGGACCAGGTCATCAAGCCTGTTAACCTGGAAGCGCTCTCCAAG
TGGACTGGCCACATCCCTGGGGATGTGGTGCGGGACATGGCCCAGATCGCCCCCATGCTG
GCTCAGCTCGGCTATGACCCTTATGCAAACCCCCCCAACTATGGCAACCCTGACCCCTTC
GTCATCAACAACACACAGCGGGTCTTGAAAGGGGACTATAAAACACCAGCCAATCTGAAA
GGATATTTTCAGGTGAACCAGAACAGCACCTCCTCCCACTTAGGAAGCTCGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 377 |
| Molecular Weight
| 41911.47 |
| Theoretical pI
| 9.089 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Protein-tyrosine sulfotransferase 2
MRLSVRRVLLAAGCALVLVLAVQLGQQVLECRAVLAGLRSPRGAMRPEQEELVMVGTNHV
EYRYGKAMPLIFVGGVPRSGTTLMRAMLDAHPEVRCGEETRIIPRVLAMRQAWSKSGREK
LRLDEAGVTDEVLDAAMQAFILEVIAKHGEPARVLCNKDPFTLKSSVYLSRLFPNSKFLL
MVRDGRASVHSMITRKVTIAGFDLSSYRDCLTKWNKAIEVMYAQCMEVGKEKCLPVYYEQ
LVLHPRRSLKLILDFLGIAWSDAVLHHEDLIGKPGGVSLSKIERSTDQVIKPVNLEALSK
WTGHIPGDVVRDMAQIAPMLAQLGYDPYANPPNYGNPDPFVINNTQRVLKGDYKTPANLK
GYFQVNQNSTSSHLGSS
|
| External Links |
|---|
| GenBank ID Protein
| 3617846 |
| UniProtKB/Swiss-Prot ID
| O60704 |
| UniProtKB/Swiss-Prot Entry Name
| TPST2_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| AF049891 |
| GeneCard ID
| TPST2 |
| GenAtlas ID
| TPST2 |
| HGNC ID
| HGNC:12021 |
| References |
|---|
| General References
| Not Available |