Showing Protein Heparan sulfate glucosamine 3-O-sulfotransferase 4 (CDBP00342)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 2 compounds
Identification
HMDB Protein ID CDBP00342
Secondary Accession Numbers Not Available
Name Heparan sulfate glucosamine 3-O-sulfotransferase 4
Description Not Available
Synonyms
  1. 3-OST-4
  2. Heparan sulfate 3-O-sulfotransferase 4
  3. Heparan sulfate D-glucosaminyl 3-O-sulfotransferase 4
  4. h3-OST-4
Gene Name HS3ST4
Protein Type Enzyme
Biological Properties
General Function Involved in sulfotransferase activity
Specific Function Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to an N-unsubstituted glucosamine linked to a 2-O-sulfo iduronic acid unit on heparan sulfate. Unlike 3-OST-1, does not convert non-anticoagulant heparan sulfate to anticoagulant heparan sulfate (By similarity).
GO Classification
Biological Process
heparan sulfate proteoglycan metabolic process
Cellular Component
extracellular region
integral to membrane
Golgi membrane
Function
transferase activity
transferase activity, transferring sulfur-containing groups
sulfotransferase activity
catalytic activity
Molecular Function
[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity
Cellular Location
  1. Golgi apparatus membrane
  2. Single-pass type II membrane protein (Probable)
Pathways
Gene Properties
Chromosome Location 16
Locus 16p11.2
SNPs HS3ST4
Gene Sequence 
>1371 bp
ATGGCCCGGTGGCCCGCACCTCCTCCGCCTCCGCCTCCGCCTCCACCTCTGGCCGCGCCG
CCGCCGCCCGGCGCCTCTGCTAAGGGGCCGCCGGCGCGCAAGCTGCTTTTTATGTGCACC
TTGTCCCTGTCTGTCACCTACCTGTGCTACAGCCTCCTGGGCGGCTCGGGCTCCCTGCAA
TTCCCTCTGGCGCTGCAGGAGTCGCCGGGCGCCGCCGCCGAGCCCCCGCCGAGCCCGCCG
CCACCCTCTCTGCTGCCTACCCCCGTGCGCCTCGGCGCCCCCTCGCAGCCGCCCGCGCCG
CCGCCGCTGGACAACGCGAGCCACGGGGAGCCGCCCGAGCCCCCAGAGCAGCCAGCCGCC
CCCGGGACCGACGGCTGGGGGCTGCCGAGCGGCGGCGGAGGCGCCCGGGACGCCTGGCTC
CGGACCCCGCTGGCCCCCAGCGAGATGATCACGGCTCAGAGCGCGCTGCCGGAGAGGGAA
GCGCAGGAGTCCAGCACCACCGACGAGGATCTCGCAGGCCGGAGAGCGGCCAACGGGAGC
AGCGAGAGGGGCGGCGCCGTCAGCACCCCCGACTATGGGGAGAAGAAGCTGCCACAGGCG
CTCATCATCGGGGTCAAGAAAGGAGGGACCCGCGCGCTGCTGGAGGCGATCCGCGTGCAC
CCGGACGTGCGGGCGGTGGGCGTAGAGCCGCACTTCTTCGACAGGAACTACGAAAAGGGG
TTGGAGTGGTACAGAAATGTGATGCCCAAGACTTTGGATGGGCAAATAACCATGGAGAAG
ACTCCAAGTTACTTTGTGACAAATGAGGCTCCCAAGCGCATTCACTCCATGGCCAAGGAC
ATCAAACTGATTGTGGTGGTGAGAAACCCCGTGACCAGGGCCATCTCTGACTACACGCAG
ACACTGTCAAAGAAACCCGAGATCCCCACCTTTGAGGTGCTGGCCTTCAAAAACCGGACC
CTCGGGCTGATCGATGCTTCCTGGAGTGCCATTCGAATAGGGATCTATGCGCTGCATCTG
GAAAACTGGCTCCAGTATTTCCCCCTCTCCCAGATCCTCTTTGTCAGTGGTGAGCGACTC
ATTGTGGACCCCGCCGGGGAAATGGCCAAAGTACAGGATTTTCTAGGCCTCAAACGTGTT
GTGACTAAGAAGCATTTCTATTTCAACAAAACCAAGGGGTTCCCTTGCCTAAAGAAGCCA
GAAGACAGCAGTGCCCCGAGGTGCTTAGGCAAGAGCAAAGGTCGGACTCATCCTCGCATT
GACCCAGATGTCATCCACAGACTGAGGAAATTCTACAAACCCTTCAACTTGATGTTTTAC
CAAATGACTGGTCAAGATTTTCAGTGGGAACAGGAAGAGGGTGATAAATGA
Protein Properties
Number of Residues 456
Molecular Weight 49798.645
Theoretical pI 8.684
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence 
>Heparan sulfate glucosamine 3-O-sulfotransferase 4
MARWPAPPPPPPPPPPLAAPPPPGASAKGPPARKLLFMCTLSLSVTYLCYSLLGGSGSLQ
FPLALQESPGAAAEPPPSPPPPSLLPTPVRLGAPSQPPAPPPLDNASHGEPPEPPEQPAA
PGTDGWGLPSGGGGARDAWLRTPLAPSEMITAQSALPEREAQESSTTDEDLAGRRAANGS
SERGGAVSTPDYGEKKLPQALIIGVKKGGTRALLEAIRVHPDVRAVGVEPHFFDRNYEKG
LEWYRNVMPKTLDGQITMEKTPSYFVTNEAPKRIHSMAKDIKLIVVVRNPVTRAISDYTQ
TLSKKPEIPTFEVLAFKNRTLGLIDASWSAIRIGIYALHLENWLQYFPLSQILFVSGERL
IVDPAGEMAKVQDFLGLKRVVTKKHFYFNKTKGFPCLKKPEDSSAPRCLGKSKGRTHPRI
DPDVIHRLRKFYKPFNLMFYQMTGQDFQWEQEEGDK
GenBank ID Protein 46398191
UniProtKB/Swiss-Prot ID Q9Y661
UniProtKB/Swiss-Prot Entry Name HS3S4_HUMAN
PDB IDs Not Available
GenBank Gene ID AF105378
GeneCard ID HS3ST4
GenAtlas ID HS3ST4
HGNC ID HGNC:5200
References
General References Not Available