| Identification |
|---|
| HMDB Protein ID
| CDBP00337 |
| Secondary Accession Numbers
| Not Available |
| Name
| Heparan sulfate glucosamine 3-O-sulfotransferase 1 |
| Description
| Not Available |
| Synonyms
|
- 3-OST-1
- Heparan sulfate 3-O-sulfotransferase 1
- Heparan sulfate D-glucosaminyl 3-O-sulfotransferase 1
- h3-OST-1
|
| Gene Name
| HS3ST1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in sulfotransferase activity |
| Specific Function
| Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to position 3 of glucosamine residues in heparan. Catalyzes the rate limiting step in the biosynthesis of heparan sulfate (HSact). This modification is a crucial step in the biosynthesis of anticoagulant heparan sulfate as it completes the structure of the antithrombin pentasaccharide binding site.
|
| GO Classification
|
| Biological Process |
| small molecule metabolic process |
| glycosaminoglycan biosynthetic process |
| carbohydrate metabolic process |
| Cellular Component |
| Golgi lumen |
| integral to membrane |
| Function |
| catalytic activity |
| transferase activity |
| transferase activity, transferring sulfur-containing groups |
| sulfotransferase activity |
| Molecular Function |
| [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity |
| sulfotransferase activity |
|
| Cellular Location
|
- Golgi apparatus lumen (Probable)
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Glycosaminoglycan biosynthesis - heparan sulfate / heparin | Not Available |  |
|
| Gene Properties |
|---|
| Chromosome Location
| 4 |
| Locus
| 4p16 |
| SNPs
| HS3ST1 |
| Gene Sequence
|
>924 bp
ATGGCCGCGCTGCTCCTGGGCGCGGTGCTGCTGGTGGCCCAGCCCCAGCTAGTGCCTTCC
CGCCCCGCCGAGCTAGGCCAGCAGGAGCTTCTGCGGAAAGCGGGGACCCTCCAGGATGAC
GTCCGCGATGGCGTGGCCCCAAACGGCTCTGCCCAGCAGTTGCCGCAGACCATCATCATC
GGCGTGCGCAAGGGCGGCACGCGCGCACTGCTGGAGATGCTCAGCCTGCACCCCGACGTG
GCGGCCGCGGAGAACGAGGTCCACTTCTTCGACTGGGAGGAGCATTACAGCCACGGCTTG
GGCTGGTACCTCAGCCAGATGCCCTTCTCCTGGCCACACCAGCTCACAGTGGAGAAGACC
CCCGCGTATTTCACGTCGCCCAAAGTGCCTGAGCGAGTCTACAGCATGAACCCGTCCATC
CGGCTGCTGCTCATCCTGCGAGACCCGTCGGAGCGCGTGCTATCTGACTACACCCAAGTG
TTCTACAACCACATGCAGAAGCACAAGCCCTACCCGTCCATCGAGGAGTTCCTGGTGCGC
GATGGCAGGCTCAATGTGGACTACAAGGCCCTCAACCGCAGCCTCTACCACGTGCACATG
CAGAACTGGCTGCGCTTTTTCCCGCTGCGCCACATCCACATTGTGGACGGCGACCGCCTC
ATCAGGGACCCCTTCCCTGAGATCCAAAAGGTCGAGAGGTTCCTAAAGCTGTCGCCGCAG
ATCAATGCTTCGAACTTCTACTTTAACAAAACCAAGGGCTTTTACTGCCTGCGGGACAGC
GGCCGGGACCGCTGCTTACATGAGTCCAAAGGCCGGGCGCACCCCCAAGTCGATCCCAAA
CTACTCAATAAACTGCACGAATATTTTCATGAGCCAAATAAGAAGTTCTTCGAGCTTGTT
GGCAGAACATTTGACTGGCACTGA
|
| Protein Properties |
|---|
| Number of Residues
| 307 |
| Molecular Weight
| 35772.77 |
| Theoretical pI
| 8.84 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Heparan sulfate glucosamine 3-O-sulfotransferase 1
MAALLLGAVLLVAQPQLVPSRPAELGQQELLRKAGTLQDDVRDGVAPNGSAQQLPQTIII
GVRKGGTRALLEMLSLHPDVAAAENEVHFFDWEEHYSHGLGWYLSQMPFSWPHQLTVEKT
PAYFTSPKVPERVYSMNPSIRLLLILRDPSERVLSDYTQVFYNHMQKHKPYPSIEEFLVR
DGRLNVDYKALNRSLYHVHMQNWLRFFPLRHIHIVDGDRLIRDPFPEIQKVERFLKLSPQ
INASNFYFNKTKGFYCLRDSGRDRCLHESKGRAHPQVDPKLLNKLHEYFHEPNKKFFELV
GRTFDWH
|
| External Links |
|---|
| GenBank ID Protein
| 2618973 |
| UniProtKB/Swiss-Prot ID
| O14792 |
| UniProtKB/Swiss-Prot Entry Name
| HS3S1_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| AF019386 |
| GeneCard ID
| HS3ST1 |
| GenAtlas ID
| HS3ST1 |
| HGNC ID
| HGNC:5194 |
| References |
|---|
| General References
| Not Available |