Cannabis Compound Database: Showing Protein Nicotinamide mononucleotide adenylyltransferase 2 (CDBP00332)

Identification Biological properties Gene properties Protein properties External links References XML Show 5 compounds

Identification

HMDB Protein ID

CDBP00332

Secondary Accession Numbers

Not Available

Name

Nicotinamide mononucleotide adenylyltransferase 2

Description

Not Available

Synonyms

NMN adenylyltransferase 2
NaMN adenylyltransferase 2
Nicotinate-nucleotide adenylyltransferase 2

Gene Name

NMNAT2

Protein Type

Enzyme

Biological Properties

General Function

Involved in nucleotidyltransferase activity

Specific Function

Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate but with a lower efficiency. Cannot use triazofurin monophosphate (TrMP) as substrate. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity prefers NAD(+), NADH and NAAD as substrates and degrades nicotinic acid adenine dinucleotide phosphate (NHD) less effectively. Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NAADP(+).

GO Classification

Biological Process
NAD biosynthetic process
water-soluble vitamin metabolic process
Cellular Component
nucleus
trans-Golgi network
late endosome
Golgi membrane
Function
catalytic activity
transferase activity
transferase activity, transferring phosphorus-containing groups
nucleotidyltransferase activity
Molecular Function
nicotinate-nucleotide adenylyltransferase activity
ATP binding
nicotinamide-nucleotide adenylyltransferase activity
Process
metabolic process
coenzyme biosynthetic process
pyridine nucleotide biosynthetic process
nicotinamide nucleotide biosynthetic process
nad biosynthetic process
cellular metabolic process
biosynthetic process
cofactor metabolic process
coenzyme metabolic process

Cellular Location

Cytoplasm
Golgi apparatus

Pathways

Name	SMPDB/Pathwhiz	KEGG
NAD(+) biosynthesis	Not Available	Not Available
Nicotinate and Nicotinamide Metabolism

Gene Properties

Chromosome Location

Locus

1q25

SNPs

NMNAT2

Gene Sequence

>924 bp
ATGACCGAGACCACCAAGACCCACGTTATCTTGCTCGCCTGCGGCAGCTTCAATCCCATC
ACCAAAGGGCACATTCAGATGTTTGAAAGAGCCAGGGATTATCTGCACAAAACTGGAAGG
TTTATTGTGATTGGCGGGATTGTCTCCCCTGTCCACGACTCCTATGGAAAACAGGGCCTC
GTGTCAAGCCGGCACCGTCTCATCATGTGTCAGCTGGCCGTCCAGAATTCTGATTGGATC
AGGGTGGACCCTTGGGAGTGCTACCAGGACACCTGGCAGACGACCTGCAGCGTGTTGGAA
CACCACCGGGACCTCATGAAGAGGGTGACTGGCTGCATCCTCTCCAATGTCAACACACCT
TCCATGACACCTGTGATCGGACAGCCACAAAACGAGACCCCCCAGCCCATTTACCAGAAC
AGCAACGTGGCCACCAAGCCCACTGCAGCCAAGATCTTGGGGAAGGTGGGAGAAAGCCTC
AGCCGGATCTGCTGTGTCCGCCCGCCGGTGGAGCGTTTCACCTTTGTAGATGAGAATGCC
AATCTGGGCACGGTGATGCGGTATGAAGAGATTGAGCTACGGATCCTGCTGCTGTGTGGT
AGTGACCTGCTGGAGTCCTTCTGCATCCCAGGGCTCTGGAACGAGGCAGATATGGAGGTG
ATTGTTGGTGACTTTGGGATTGTGGTGGTGCCCCGGGATGCAGCCGACACAGACCGAATC
ATGAATCACTCCTCAATACTCCGCAAATACAAAAACAACATCATGGTGGTGAAGGATGAC
ATCAACCATCCCATGTCTGTTGTCAGCTCAACCAAGAGCAGGCTGGCCCTGCAGCATGGG
GACGGCCATGTTGTGGATTACCTGTCCCAGCCGGTCATCGACTACATCCTCAAAAGCCAG
CTGTACATCAATGCCTCCGGCTAG

Protein Properties

Number of Residues

307

Molecular Weight

34438.38

Theoretical pI

7.06

Pfam Domain Function

CTP_transf_2 (PF01467 )

Signals

Not Available

Transmembrane Regions

Not Available

Protein Sequence

>Nicotinamide mononucleotide adenylyltransferase 2
MTETTKTHVILLACGSFNPITKGHIQMFERARDYLHKTGRFIVIGGIVSPVHDSYGKQGL
VSSRHRLIMCQLAVQNSDWIRVDPWECYQDTWQTTCSVLEHHRDLMKRVTGCILSNVNTP
SMTPVIGQPQNETPQPIYQNSNVATKPTAAKILGKVGESLSRICCVRPPVERFTFVDENA
NLGTVMRYEEIELRILLLCGSDLLESFCIPGLWNEADMEVIVGDFGIVVVPRDAADTDRI
MNHSSILRKYKNNIMVVKDDINHPMSVVSSTKSRLALQHGDGHVVDYLSQPVIDYILKSQ
LYINASG

External Links

GenBank ID Protein

24307989

UniProtKB/Swiss-Prot ID

Q9BZQ4

UniProtKB/Swiss-Prot Entry Name

NMNA2_HUMAN

PDB IDs

Not Available

GenBank Gene ID

NM_015039.2

GeneCard ID