| Identification |
|---|
| HMDB Protein ID
| CDBP00329 |
| Secondary Accession Numbers
| Not Available |
| Name
| Nicotinamide mononucleotide adenylyltransferase 1 |
| Description
| Not Available |
| Synonyms
|
- NMN adenylyltransferase 1
- NaMN adenylyltransferase 1
- Nicotinate-nucleotide adenylyltransferase 1
- SubName: Nicotinamide nucleotide adenylyltransferase 1, isoform CRA_a
- SubName: cDNA, FLJ96727, Homo sapiens nicotinamide nucleotide adenylyltransferase 1(NMNAT1), mRNA
|
| Gene Name
| NMNAT1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in nucleotidyltransferase activity |
| Specific Function
| Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate with the same efficiency. Can use triazofurin monophosphate (TrMP) as substrate. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity, prefers NAD(+) and NAAD as substrates and degrades NADH, nicotinic acid adenine dinucleotide phosphate (NHD) and nicotinamide guanine dinucleotide (NGD) less effectively. Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NAADP(+). Protects against axonal degeneration following mechanical or toxic insults.
|
| GO Classification
|
| Biological Process |
| NAD biosynthetic process |
| water-soluble vitamin metabolic process |
| Cellular Component |
| nucleoplasm |
| Function |
| catalytic activity |
| transferase activity |
| transferase activity, transferring phosphorus-containing groups |
| nucleotidyltransferase activity |
| Molecular Function |
| ATP binding |
| nicotinamide-nucleotide adenylyltransferase activity |
| nicotinate-nucleotide adenylyltransferase activity |
| Process |
| biosynthetic process |
| cofactor metabolic process |
| coenzyme metabolic process |
| metabolic process |
| coenzyme biosynthetic process |
| pyridine nucleotide biosynthetic process |
| nicotinamide nucleotide biosynthetic process |
| nad biosynthetic process |
| cellular metabolic process |
|
| Cellular Location
|
- Nucleus
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | NAD(+) biosynthesis | Not Available | Not Available |
|
| Gene Properties |
|---|
| Chromosome Location
| 1 |
| Locus
| 1p36.22 |
| SNPs
| NMNAT1 |
| Gene Sequence
|
>840 bp
ATGGAAAATTCCGAGAAGACTGAAGTGGTTCTCCTTGCTTGTGGTTCATTCAATCCCATC
ACCAACATGCACCTCAGGTTGTTTGAGCTGGCCAAGGACTACATGAATGGAACAGGAAGG
TACACAGTTGTCAAAGGCATCATCTCTCCTGTTGGTGATGCCTACAAGAAGAAAGGACTC
ATTCCTGCCTATCACCGGGTCATCATGGCAGAACTTGCTACCAAGAATTCTAAATGGGTG
GAAGTTGATACATGGGAAAGTCTTCAGAAGGAGTGGAAAGAGACTCTGAAGGTGCTAAGA
CACCATCAAGAGAAATTGGAGGCTAGTGACTGTGATCACCAGCAGAACTCACCTACTCTA
GAAAGGCCTGGAAGGAAGAGGAAGTGGACTGAAACACAAGATTCTAGTCAAAAGAAATCC
CTAGAGCCAAAAACAAAAGCTGTGCCAAAGGTCAAGCTGCTGTGTGGGGCAGATTTATTG
GAGTCCTTTGCTGTTCCCAATTTGTGGAAGAGTGAAGACATCACCCAAATCGTGGCCAAC
TATGGGCTCATATGTGTTACTCGGGCTGGAAATGATGCTCAGAAGTTTATCTATGAATCG
GATGTGCTGTGGAAACACCGGAGCAACATTCACGTGGTGAATGAATGGATCGCTAATGAC
ATCTCATCCACAAAAATCCGGAGAGCCCTCAGAAGGGGCCAGAGCATTCGCTACTTGGTA
CCAGATCTTGTCCAAGAATACATTGAAAAGCATAATTTGTACAGCTCTGAGAGTGAAGAC
AGGAATGCTGGGGTCATCCTGGCCCCTTTGCAGAGAAACACTGCAGAAGCTAAGACATAG
|
| Protein Properties |
|---|
| Number of Residues
| 279 |
| Molecular Weight
| 31932.22 |
| Theoretical pI
| 8.86 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Nicotinamide mononucleotide adenylyltransferase 1
MENSEKTEVVLLACGSFNPITNMHLRLFELAKDYMNGTGRYTVVKGIISPVGDAYKKKGL
IPAYHRVIMAELATKNSKWVEVDTWESLQKEWKETLKVLRHHQEKLEASDCDHQQNSPTL
ERPGRKRKWTETQDSSQKKSLEPKTKAVPKVKLLCGADLLESFAVPNLWKSEDITQIVAN
YGLICVTRAGNDAQKFIYESDVLWKHRSNIHVVNEWIANDISSTKIRRALRRGQSIRYLV
PDLVQEYIEKHNLYSSESEDRNAGVILAPLQRNTAEAKT
|
| External Links |
|---|
| GenBank ID Protein
| 189055023 |
| UniProtKB/Swiss-Prot ID
| Q9HAN9 |
| UniProtKB/Swiss-Prot Entry Name
| NMNA1_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| AF314163 |
| GeneCard ID
| NMNAT1 |
| GenAtlas ID
| NMNAT1 |
| HGNC ID
| HGNC:17877 |
| References |
|---|
| General References
| Not Available |