| Identification |
|---|
| HMDB Protein ID
| CDBP00313 |
| Secondary Accession Numbers
| Not Available |
| Name
| Sialidase-3 |
| Description
| Not Available |
| Synonyms
|
- Ganglioside sialidase
- Membrane sialidase
- N-acetyl-alpha-neuraminidase 3
|
| Gene Name
| NEU3 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in exo-alpha-sialidase activity |
| Specific Function
| Plays a role in modulating the ganglioside content of the lipid bilayer at the level of membrane-bound sialyl glycoconjugates |
| GO Classification
|
Not Available
|
| Cellular Location
|
- Peripheral membrane protein
- Membrane
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Sphingolipid Metabolism |    |  | | Gaucher Disease |    | Not Available | | Globoid Cell Leukodystrophy |    | Not Available | | Metachromatic Leukodystrophy (MLD) |    | Not Available | | Fabry disease |    | Not Available |
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 11q13.5 |
| SNPs
| NEU3 |
| Gene Sequence
|
>1287 bp
ATGGAAGAAGTGACAACATGCTCCTTCAACAGCCCTCTGTTCCGGCAGGAAGATGACAGA
GGGATTACCTACCGGATCCCAGCCCTGCTCTACATACCCCCCACCCACACCTTCCTGGCC
TTTGCAGAGAAGCGTTCCACGAGGAGAGATGAGGATGCTCTCCACCTGGTGCTGAGGCGA
GGGTTGAGGATTGGGCAGTTGGTACAGTGGGGGCCCCTGAAGCCACTGATGGAAGCCACA
CTACCGGGGCATCGGACCATGAACCCCTGTCCTGTATGGGAGCAGAAGAGTGGTTGTGTG
TTCCTGTTCTTCATCTGTGTGCGGGGCCATGTCACAGAGCGTCAACAGATTGTGTCAGGC
AGGAATGCTGCCCGCCTTTGCTTCATCTACAGTCAGGATGCTGGATGTTCATGGAGTGAG
GTGAGGGACTTGACTGAGGAGGTCATTGGCTCAGAGCTGAAGCACTGGGCCACATTTGCT
GTGGGCCCAGGTCATGGCATCCAGCTGCAGTCAGGGAGACTGGTCATCCCTGCGTATACC
TACTACATCCCTTCCTGGTTCTTTTGCTTCCAGCTACCATGTAAAACCAGGCCTCATTCT
CTGATGATCTACAGTGATGACCTAGGGGTCACATGGCACCATGGTAGACTCATTAGGCCC
ATGGTTACAGTAGAATGTGAAGTGGCAGAGGTGACTGGGAGGGCTGGCCACCCTGTGCTA
TATTGCAGTGCCCGGACACCAAACAGGTGCCGGGCAGAGGCGCTCAGCACTGACCATGGT
GAAGGCTTTCAGAGACTGGCCCTGAGTCGACAGCTCTGTGAGCCCCCACATGGTTGCCAA
GGGAGTGTGGTAAGTTTCCGGCCCCTGGAGATCCCACATAGGTGCCAGGACTCTAGCAGC
AAAGATGCACCCACCATTCAGCAGAGCTCTCCAGGCAGTTCACTGAGGCTGGAGGAGGAA
GCTGGAACACCGTCAGAATCATGGCTCTTGTACTCACACCCAACCAGTAGGAAACAGAGG
GTTGACCTAGGTATCTATCTCAACCAGACCCCCTTGGAGGCTGCCTGCTGGTCCCGCCCC
TGGATCTTGCACTGTGGGCCCTGTGGCTACTCTGATCTGGCTGCTCTGGAGGAGGAGGGC
TTGTTTGGGTGTTTGTTTGAATGTGGGACCAAGCAAGAGTGTGAGCAGATTGCCTTCCGC
CTGTTTACACACCGGGAGATCCTGAGTCACCTGCAGGGGGACTGCACCAGCCCTGGTAGG
AACCCAAGCCAATTCAAAAGCAATTAA
|
| Protein Properties |
|---|
| Number of Residues
| 428 |
| Molecular Weight
| 48251.5 |
| Theoretical pI
| 7.17 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Sialidase-3
MEEVTTCSFNSPLFRQEDDRGITYRIPALLYIPPTHTFLAFAEKRSTRRDEDALHLVLRR
GLRIGQLVQWGPLKPLMEATLPGHRTMNPCPVWEQKSGCVFLFFICVRGHVTERQQIVSG
RNAARLCFIYSQDAGCSWSEVRDLTEEVIGSELKHWATFAVGPGHGIQLQSGRLVIPAYT
YYIPSWFFCFQLPCKTRPHSLMIYSDDLGVTWHHGRLIRPMVTVECEVAEVTGRAGHPVL
YCSARTPNRCRAEALSTDHGEGFQRLALSRQLCEPPHGCQGSVVSFRPLEIPHRCQDSSS
KDAPTIQQSSPGSSLRLEEEAGTPSESWLLYSHPTSRKQRVDLGIYLNQTPLEAACWSRP
WILHCGPCGYSDLAALEEEGLFGCLFECGTKQECEQIAFRLFTHREILSHLQGDCTSPGR
NPSQFKSN
|
| External Links |
|---|
| GenBank ID Protein
| 5631293 |
| UniProtKB/Swiss-Prot ID
| Q9UQ49 |
| UniProtKB/Swiss-Prot Entry Name
| NEUR3_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AB008185 |
| GeneCard ID
| NEU3 |
| GenAtlas ID
| NEU3 |
| HGNC ID
| HGNC:7760 |
| References |
|---|
| General References
| Not Available |