| Identification |
|---|
| HMDB Protein ID
| CDBP00299 |
| Secondary Accession Numbers
| Not Available |
| Name
| Pyrroline-5-carboxylate reductase 2 |
| Description
| Not Available |
| Synonyms
|
- P5C reductase 2
- P5CR 2
|
| Gene Name
| PYCR2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in oxidoreductase activity |
| Specific Function
| Housekeeping enzyme that catalyzes the last step in proline biosynthesis. In some cell types, such as erythrocytes, its primary function may be the generation of NADP(+). Can utilize both NAD and NADP. Has higher affinity for NADP, but higher catalytic efficiency with NADH.
|
| GO Classification
|
| Biological Process |
| L-proline biosynthetic process |
| Cellular Component |
| cytoplasm |
| Function |
| catalytic activity |
| pyrroline-5-carboxylate reductase activity |
| oxidoreductase activity, acting on the ch-nh group of donors |
| oxidoreductase activity, acting on the ch-nh group of donors, nad or nadp as acceptor |
| oxidoreductase activity |
| binding |
| Molecular Function |
| pyrroline-5-carboxylate reductase activity |
| nucleotide binding |
| Process |
| metabolic process |
| cellular metabolic process |
| glutamine family amino acid metabolic process |
| proline metabolic process |
| proline biosynthetic process |
| oxidation reduction |
| cellular amino acid and derivative metabolic process |
| cellular amino acid metabolic process |
|
| Cellular Location
|
Not Available
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | L-proline biosynthesis | Not Available | Not Available | | Arginine and Proline Metabolism |    |  | | Prolidase Deficiency (PD) |    | Not Available | | Arginine: Glycine Amidinotransferase Deficiency (AGAT Deficiency) |    | Not Available | | Hyperprolinemia Type II |    | Not Available |
|
| Gene Properties |
|---|
| Chromosome Location
| 1 |
| Locus
| 1q42.12 |
| SNPs
| PYCR2 |
| Gene Sequence
|
>963 bp
ATGAGCGTGGGCTTCATCGGGGCCGGCCAGCTGGCTAATGCTCTGGCGCGGGGCTTCACG
GCCGCAGCATTCCTGTCGGCTCACAAGATAATAGCCAGCTCCCCAGAAATGAACCTGCCC
ACGGTGTCCGCGCTCAGGAAGATGGGTGTGAACCTGACACGCAGCAACAAGGAGACGGTG
AAGCACAGCGACGTCCTGTTTCTGGCTGTGAAGCACATTATCATCCCCTTCATCCTGGAT
GAGATTGGGGCCGACGTGCAAGCCAGACACATCGTGGTCTCCTGTGCGGCTGGTGTCACC
ATCAGCTCTGTGGAGAAGAAGCTGATGGCATTCCAGCCAGCCCCCAAAGTGATTCGCTGC
ATGACCAACACACCTGTGGTAGTGCAGGAAGGCGCTACAGTGTACGCCACGGGCACCCAT
GCCCTGGTGGAGGATGGGCAGCTCCTGGAGCAGCTCATGAGCAGCGTGGGCTTCTGCACT
GAGGTGGAAGAGGACCTCATCGATGCCGTCACGGGGCTCAGTGGCAGCGGGCCTGCCTAT
GCATTCATGGCTCTGGACGCATTGGCTGATGGTGGGGTGAAGATGGGTTTGCCACGGCGC
CTGGCAATCCAACTCGGGGCCCAGGCTTTGCTGGGAGCTGCCAAGATGCTGCTGGACTCG
GAGCAGCATCCATGCCAGCTTAAGGACAATGTCTGCTCCCCTGGGGGAGCCACCATCCAC
GCCCTGCACTTTCTAGAGAGTGGGGGCTTCCGCTCTCTGCTCATCAATGCAGTTGAGGCC
TCCTGTATCCGAACACGAGAGCTACAGTCCATGGCCGACCAAGAAAAGATCTCCCCAGCT
GCCCTTAAGAAGACCCTCTTAGACAGAGTGAAGCTGGAATCCCCCACAGTCTCCACACTG
ACCCCCTCCAGCCCAGGGAAGCTCCTCACAAGAAGCCTGGCCCTGGGAGGCAAGAAGGAC
TAA
|
| Protein Properties |
|---|
| Number of Residues
| 320 |
| Molecular Weight
| 25867.975 |
| Theoretical pI
| 9.263 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Pyrroline-5-carboxylate reductase 2
MSVGFIGAGQLAYALARGFTAAGILSAHKIIASSPEMNLPTVSALRKMGVNLTRSNKETV
KHSDVLFLAVKPHIIPFILDEIGADVQARHIVVSCAAGVTISSVEKKLMAFQPAPKVIRC
MTNTPVVVQEGATVYATGTHALVEDGQLLEQLMSSVGFCTEVEEDLIDAVTGLSGSGPAY
AFMALDALADGGVKMGLPRRLAIQLGAQALLGAAKMLLDSEQHPCQLKDNVCSPGGATIH
ALHFLESGGFRSLLINAVEASCIRTRELQSMADQEKISPAALKKTLLDRVKLESPTVSTL
TPSSPGKLLTRSLALGGKKD
|
| External Links |
|---|
| GenBank ID Protein
| 33150582 |
| UniProtKB/Swiss-Prot ID
| Q96C36 |
| UniProtKB/Swiss-Prot Entry Name
| P5CR2_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF087859 |
| GeneCard ID
| PYCR2 |
| GenAtlas ID
| PYCR2 |
| HGNC ID
| HGNC:30262 |
| References |
|---|
| General References
| Not Available |