Cannabis Compound Database: Showing Protein Aspartate aminotransferase, mitochondrial (CDBP00278)

Identification Biological properties Gene properties Protein properties External links References XML Show 12 compounds

Identification

HMDB Protein ID

CDBP00278

Secondary Accession Numbers

Not Available

Name

Aspartate aminotransferase, mitochondrial

Description

Not Available

Synonyms

FABP-1
FABPpm
Fatty acid-binding protein
Glutamate oxaloacetate transaminase 2
Plasma membrane-associated fatty acid-binding protein
Transaminase A
mAspAT
Kynurenine aminotransferase 4
Kynurenine aminotransferase IV
Kynurenine--oxoglutarate transaminase 4
Kynurenine--oxoglutarate transaminase IV

Gene Name

GOT2

Protein Type

Enzyme

Biological Properties

General Function

Involved in transferase activity, transferring nitrogenous groups

Specific Function

Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Plays a key role in amino acid metabolism. Important for metabolite exchange between mitochondria and cytosol. Facilitates cellular uptake of long-chain free fatty acids.

GO Classification

Biological Process
cellular amino acid biosynthetic process
fatty acid transport
cellular nitrogen compound metabolic process
response to ethanol
2-oxoglutarate metabolic process
glutamate metabolic process
aspartate biosynthetic process
aspartate catabolic process
gluconeogenesis
glutamate catabolic process to 2-oxoglutarate
glutamate catabolic process to aspartate
oxaloacetate metabolic process
4-hydroxyproline catabolic process
Cellular Component
mitochondrial matrix
plasma membrane
mitochondrial inner membrane
Function
binding
catalytic activity
transferase activity
transferase activity, transferring nitrogenous groups
cofactor binding
pyridoxal phosphate binding
transaminase activity
Molecular Function
kynurenine-oxoglutarate transaminase activity
pyridoxal phosphate binding
L-aspartate:2-oxoglutarate aminotransferase activity
L-phenylalanine:2-oxoglutarate aminotransferase activity
Process
metabolic process
cellular metabolic process
biosynthetic process
cellular amino acid and derivative metabolic process
cellular amino acid metabolic process

Cellular Location

Cell membrane
Mitochondrion matrix

Pathways

Name	SMPDB/Pathwhiz	KEGG
Alanine, aspartate and glutamate metabolism	Not Available
Cysteine and methionine metabolism	Not Available
Phenylalanine metabolism	Not Available
Phenylalanine, tyrosine and tryptophan biosynthesis	Not Available
2-Oxocarboxylic acid metabolism	Not Available

Gene Properties

Chromosome Location

Locus

16q21

SNPs

GOT2

Gene Sequence

>1293 bp
ATGGCCCTGCTGCATTCCGGCCGCGTCCTCCCCGGGATCGCCGCCGCCTTCCACCCGGGC
CTCGCCGCCGCGGCCTCTGCCAGAGCCAGCTCCTGGTGGACCCATGTGGAAATGGGACCT
CCAGATCCCATTCTGGGAGTCACTGAAGCCTTTAAGAGGGACACCAATAGCAAAAAGATG
AATCTGGGAGTTGGTGCCTACCGGGATGATAATGGAAAGCCTTACGTTCTGCCTAGCGTC
CGCAAGGCAGAGGCCCAGATTGCCGCAAAAAATTTGGACAAGGAATACCTGCCCATTGGG
GGACTGGCTGAATTTTGCAAGGCATCTGCAGAACTAGCCCTGGGTGAGAACAGCGAAGTC
TTGAAGAGTGGCCGGTTTGTCACTGTGCAGACCATTTCTGGAACTGGAGCCTTAAGGATC
GGAGCCAGTTTTCTGCAAAGATTTTTTAAGTTCAGCCGAGATGTCTTTCTGCCCAAACCA
ACCTGGGGAAACCACACACCCATCTTCAGGGATGCTGGCATGCAGCTACAAGGTTATCGG
TATTATGACCCCAAGACTTGCGGTTTTGACTTCACAGGCGCTGTGGAGGATATTTCAAAA
ATACCAGAGCAGAGTGTTCTTCTTCTGCATGCCTGCGCCCACAATCCCACGGGAGTGGAC
CCGCGTCCGGAACAGTGGAAGGAAATAGCAACAGTGGTGAAGAAAAGGAATCTCTTTGCG
TTCTTTGACATGGCCTACCAAGGCTTTGCCAGTGGTGATGGTGATAAGGATACCTGGGCT
GTGCGCCACTTCATCGAACAGGGCATTAATGTTTGCCTCTGCCAATCATATGCCAAGAAC
ATGGGCTTATATGGTGAGCGTGTAGGAGCCTTCACTATGGTCTGCAAAGATGCGGATGAA
GCCAAAAGGGTAGAGTCACAGTTGAAGATCTTGATCCGTCCCATGTATTCCAACCCTCCC
CTCAATGGGGCCCGGATTGCTGCTGCCATTCTGAACACCCCAGATTTGCGAAAACAATGG
CTGCAAGAAGTGAAAGTCATGGCTGACCGCATCATTGGCATGCGGACTCAACTGGTCTCC
AACCTCAAGAAGGAGGGTTCCACCCACAATTGGCAACACATCACCGACCAAATTGGCATG
TTCTGTTTCACAGGGCTAAAGCCTGAACAGGTGGAGCGGCTGATCAAGGAGTTCTCCATC
TACATGACAAAAGATGGCCGCATCTCTGTGGCAGGGGTCACCTCCAGCAACGTGGGCTAC
CTTGCCCATGCCATTCACCAGGTCACCAAGTAA

Protein Properties

Number of Residues

430

Molecular Weight

47517.285

Theoretical pI

9.005

Pfam Domain Function

Aminotran_1_2 (PF00155 )

Signals

Not Available

Transmembrane Regions

Not Available

Protein Sequence

>Aspartate aminotransferase, mitochondrial
MALLHSGRVLPGIAAAFHPGLAAAASARASSWWTHVEMGPPDPILGVTEAFKRDTNSKKM
NLGVGAYRDDNGKPYVLPSVRKAEAQIAAKNLDKEYLPIGGLAEFCKASAELALGENSEV
LKSGRFVTVQTISGTGALRIGASFLQRFFKFSRDVFLPKPTWGNHTPIFRDAGMQLQGYR
YYDPKTCGFDFTGAVEDISKIPEQSVLLLHACAHNPTGVDPRPEQWKEIATVVKKRNLFA
FFDMAYQGFASGDGDKDAWAVRHFIEQGINVCLCQSYAKNMGLYGERVGAFTMVCKDADE
AKRVESQLKILIRPMYSNPPLNGARIAAAILNTPDLRKQWLQEVKVMADRIIGMRTQLVS
NLKKEGSTHNWQHITDQIGMFCFTGLKPEQVERLIKEFSIYMTKDGRISVAGVTSSNVGY
LAHAIHQVTK

External Links

GenBank ID Protein

62898103

UniProtKB/Swiss-Prot ID

P00505

UniProtKB/Swiss-Prot Entry Name

AATM_HUMAN

PDB IDs

Not Available

GenBank Gene ID

AK223271

GeneCard ID