| Identification |
|---|
| HMDB Protein ID
| CDBP00269 |
| Secondary Accession Numbers
| Not Available |
| Name
| Phenylalanine--tRNA ligase, mitochondrial |
| Description
| Not Available |
| Synonyms
|
- PheRS
- Phenylalanine--tRNA ligase
- Phenylalanyl-tRNA synthetase
|
| Gene Name
| FARS2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in nucleotide binding |
| Specific Function
| Catalyzes direct attachment of p-Tyr (Tyr) to tRNAPhe. Permits also, with a lower efficiency, the attachment of m-Tyr to tRNAPhe, thereby opening the way for delivery of the misacylated tRNA to the ribosome and incorporation of ROS-damaged amino acid into proteins.
|
| GO Classification
|
| Biological Process |
| phenylalanyl-tRNA aminoacylation |
| tRNA processing |
| Cellular Component |
| mitochondrial matrix |
| Component |
| cell part |
| intracellular part |
| cytoplasm |
| Function |
| binding |
| aminoacyl-trna ligase activity |
| nucleotide binding |
| catalytic activity |
| nucleoside binding |
| purine nucleoside binding |
| adenyl nucleotide binding |
| adenyl ribonucleotide binding |
| atp binding |
| magnesium ion binding |
| ligase activity |
| nucleic acid binding |
| rna binding |
| trna binding |
| phenylalanine-trna ligase activity |
| ion binding |
| ligase activity, forming carbon-oxygen bonds |
| cation binding |
| ligase activity, forming aminoacyl-trna and related compounds |
| metal ion binding |
| Molecular Function |
| magnesium ion binding |
| ATP binding |
| phenylalanine-tRNA ligase activity |
| tRNA binding |
| Process |
| cellular macromolecule metabolic process |
| biosynthetic process |
| phenylalanyl-trna aminoacylation |
| rna metabolic process |
| ncrna metabolic process |
| trna metabolic process |
| trna aminoacylation |
| trna aminoacylation for protein translation |
| macromolecule biosynthetic process |
| cellular macromolecule biosynthetic process |
| translation |
| trna processing |
| metabolic process |
| macromolecule metabolic process |
|
| Cellular Location
|
- Mitochondrion matrix (Potential)
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Aminoacyl-tRNA biosynthesis | Not Available |  |
|
| Gene Properties |
|---|
| Chromosome Location
| 6 |
| Locus
| 6p25.1 |
| SNPs
| FARS2 |
| Gene Sequence
|
>1356 bp
ATGGTGGGCTCAGCTCTCAGGAGAGGTGCCCATGCATATGTCTACCTGGTGAGTAAGGCC
AGTCACATCTCCAGAGGCCATCAGCACCAGGCCTGGGGATCGAGGCCTCCTGCAGCAGAG
TGTGCCACCCAAAGAGCTCCAGGCAGTGTGGTGGAGCTGCTGGGCAAATCCTACCCTCAG
GACGACCACAGCAACCTCACCCGGAAGGTCCTCACCAGAGTTGGCAGGAACCTGCACAAC
CAGCAGCATCACCCTCTGTGGCTGATCAAGGAGAGGGTGAAGGAGCACTTCTACAAGCAG
TATGTGGGCCGCTTTGGGACCCCGTTGTTCTCGGTCTACGACAACCTTTCTCCAGTGGTC
ACGACCTGGCAGAACTTTGACAGCCTGCTCATCCCAGCTGATCACCCCAGCAGGAAGAAG
GGGGACAACTATTACCTGAATCGGACTCACATGCTGAGAGCGCACACGTCTGCACACCAG
TGGGACTTGCTGCACGCGGGACTGGATGCCTTCCTGGTGGTGGGTGATGTCTACAGGCGT
GACCAGATCGACTCCCAGCACTACCCTATTTTCCACCAGCTGGAGGCCGTGCGGCTCTTC
TCCAAGCATGAGTTATTTGCTGGTATAAAGGATGGAGAAAGCCTGCAGCTCTTTGAACAA
AGTTCTCGCTCTGCGCATAAACAAGAGACACACACCATGGAGGCCGTGAAGCTTGTAGAG
TTTGATCTTAAGCAAACGCTTACCAGGCTCATGGCACATCTTTTTGGAGATGAGCTGGAG
ATAAGATGGGTAGACTGCTACTTCCCTTTTACACATCCTTCCTTTGAGATGGAGATCAAC
TTTCATGGAGAATGGCTGGAAGTTCTTGGCTGCGGGGTGATGGAACAACAACTGGTCAAT
TCAGCTGGTGCTCAAGACCGAATCGGCTGGGCTTTTGGCCTAGGATTAGAAAGGCTAGCC
ATGATCCTCTACGACATCCCTGATATCCGTCTCTTCTGGTGTGAGGACGAGCGCTTCCTG
AAGCAGTTCTGTGTATCCAACATTAATCAGAAGGTGAAGTTTCAGCCTCTTAGCAAATAT
CCGGCTGTGATCAATGATATTTCATTCTGGTTGCCCTCTGAGAATTACGCAGAAAATGAT
TTCTATGACTTAGTCCGAACAATTGGAGGAGACCTGGTGGAAAAGGTTGATCTCATAGAC
AAGTTTGTACATCCAAAGACGCACAAGACCAGCCACTGCTACCGCATCACGTACCGCCAC
ATGGAACGGACTCTGTCCCAGAGAGAGGTCAGGCACATCCACCAGGCCTTGCAGGAGGCT
GCAGTCCAGCTGTTGGGTGTGGAGGGCAGGTTCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 451 |
| Molecular Weight
| 52356.21 |
| Theoretical pI
| 7.457 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Phenylalanyl-tRNA synthetase, mitochondrial
MVGSALRRGAHAYVYLVSKASHISRGHQHQAWGSRPPAAECATQRAPGSVVELLGKSYPQ
DDHSNLTRKVLTRVGRNLHNQQHHPLWLIKERVKEHFYKQYVGRFGTPLFSVYDNLSPVV
TTWQNFDSLLIPADHPSRKKGDNYYLNRTHMLRAHTSAHQWDLLHAGLDAFLVVGDVYRR
DQIDSQHYPIFHQLEAVRLFSKHELFAGIKDGESLQLFEQSSRSAHKQETHTMEAVKLVE
FDLKQTLTRLMAHLFGDELEIRWVDCYFPFTHPSFEMEINFHGEWLEVLGCGVMEQQLVN
SAGAQDRIGWAFGLGLERLAMILYDIPDIRLFWCEDERFLKQFCVSNINQKVKFQPLSKY
PAVINDISFWLPSENYAENDFYDLVRTIGGDLVEKVDLIDKFVHPKTHKTSHCYRITYRH
MERTLSQREVRHIHQALQEAAVQLLGVEGRF
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| O95363 |
| UniProtKB/Swiss-Prot Entry Name
| SYFM_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| AF097441 |
| GeneCard ID
| FARS2 |
| GenAtlas ID
| FARS2 |
| HGNC ID
| HGNC:21062 |
| References |
|---|
| General References
| Not Available |