Showing Protein Catechol O-methyltransferase (CDBP00266)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 14 compounds
Identification
HMDB Protein ID CDBP00266
Secondary Accession Numbers Not Available
Name Catechol O-methyltransferase
Description Not Available
Synonyms Not Available
Gene Name COMT
Protein Type Enzyme
Biological Properties
General Function Involved in magnesium ion binding
Specific Function Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol.
GO Classification
Biological Process
learning
dopamine catabolic process
neurotransmitter catabolic process
response to organic cyclic compound
small molecule metabolic process
estrogen metabolic process
multicellular organismal reproductive process
negative regulation of dopamine metabolic process
positive regulation of homocysteine metabolic process
response to pain
female pregnancy
response to lipopolysaccharide
neurotransmitter biosynthetic process
response to drug
xenobiotic metabolic process
negative regulation of smooth muscle cell proliferation
Cellular Component
cytosol
mitochondrion
plasma membrane
intracellular membrane-bounded organelle
integral to membrane
Function
magnesium ion binding
catechol o-methyltransferase activity
transferase activity, transferring one-carbon groups
methyltransferase activity
o-methyltransferase activity
ion binding
cation binding
metal ion binding
binding
catalytic activity
transferase activity
Molecular Function
catechol O-methyltransferase activity
O-methyltransferase activity
magnesium ion binding
Process
neurotransmitter metabolic process
neurotransmitter catabolic process
metabolic process
biological regulation
cellular metabolic process
cellular amino acid derivative metabolic process
cellular biogenic amine metabolic process
cellular amino acid and derivative metabolic process
catecholamine metabolic process
regulation of biological quality
regulation of neurotransmitter levels
Cellular Location
  1. Single-pass type II membrane protein
  2. Isoform Membrane-bound:Cell membrane
  3. Extracellular side
Pathways
Gene Properties
Chromosome Location 22
Locus 22q11.21
SNPs COMT
Gene Sequence 
>816 bp
ATGCCGGAGGCCCCGCCTCTGCTGTTGGCAGCTGTGTTGCTGGGCCTGGTGCTGCTGGTG
GTGCTGCTGCTGCTTCTGAGGCACTGGGGCTGGGGCCTGTGCCTTATCGGCTGGAACGAG
TTCATCCTGCAGCCCATCCACAACCTGCTCATGGGTGACACCAAGGAGCAGCGCATCCTG
AACCACGTGCTGCAGCATGCGGAGCCCGGGAACGCACAGAGCGTGCTGGAGGCCATTGAC
ACCTACTGCGAGCAGAAGGAGTGGGCCATGAACGTGGGCGACAAGAAAGGCAAGATCGTG
GACGCCGTGATTCAGGAGCACCAGCCCTCCGTGCTGCTGGAGCTGGGGGCCTACTGTGGC
TACTCAGCTGTGCGCATGGCCCGCCTGCTGTCACCAGGGGCGAGGCTCATCACCATCGAG
ATCAACCCCGACTGTGCCGCCATCACCCAGCGGATGGTGGATTTCGCTGGCGTGAAGGAC
AAGGTCACCCTTGTGGTTGGAGCGTCCCAGGACATCATCCCCCAGCTGAAGAAGAAGTAT
GATGTGGACACACTGGACATGGTCTTCCTCGACCACTGGAAGGACCGGTACCTGCCGGAC
ACGCTTCTCTTGGAGGAATGTGGCCTGCTGCGGAAGGGGACAGTGCTACTGGCTGACAAC
GTGATCTGCCCAGGTGCGCCAGACTTCCTAGCACACGTGCGCGGGAGCAGCTGCTTTGAG
TGCACACACTACCAATCGTTCCTGGAATACAGGGAGGTGGTGGACGGCCTGGAGAAGGCC
ATCTACAAGGGCCCAGGCAGCGAAGCAGGGCCCTGA
Protein Properties
Number of Residues 271
Molecular Weight 30036.77
Theoretical pI 5.467
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence 
>Catechol O-methyltransferase
MPEAPPLLLAAVLLGLVLLVVLLLLLRHWGWGLCLIGWNEFILQPIHNLLMGDTKEQRIL
NHVLQHAEPGNAQSVLEAIDTYCEQKEWAMNVGDKKGKIVDAVIQEHQPSVLLELGAYCG
YSAVRMARLLSPGARLITIEINPDCAAITQRMVDFAGVKDKVTLVVGASQDIIPQLKKKY
DVDTLDMVFLDHWKDRYLPDTLLLEECGLLRKGTVLLADNVICPGAPDFLAHVRGSSCFE
CTHYQSFLEYREVVDGLEKAIYKGPGSEAGP
GenBank ID Protein 180920
UniProtKB/Swiss-Prot ID P21964
UniProtKB/Swiss-Prot Entry Name COMT_HUMAN
PDB IDs
GenBank Gene ID M65212
GeneCard ID COMT
GenAtlas ID COMT
HGNC ID HGNC:2228
References
General References Not Available